ID Q6IWH5_SALSA Unreviewed; 260 AA.
AC Q6IWH5;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Interleukin-1 {ECO:0000256|RuleBase:RU003753};
GN Name=LOC100136449 {ECO:0000313|RefSeq:NP_001117054.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:AAT36642.1};
RN [1] {ECO:0000313|EMBL:AAT36642.1, ECO:0000313|RefSeq:NP_001117054.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16436123; DOI=10.1111/j.1365-2761.2006.00696.x;
RA Lindenstrom T., Sigh J., Dalgaard M.B., Buchmann K.;
RT "Skin expression of IL-1beta in East Atlantic salmon, Salmo salar L.,
RT highly susceptible to Gyrodactylus salaris infection is enhanced compared
RT to a low susceptibility Baltic stock.";
RL J. Fish Dis. 29:123-128(2006).
RN [2] {ECO:0000313|RefSeq:NP_001117054.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Secreted, extracellular exosome
CC {ECO:0000256|ARBA:ARBA00004550}.
CC -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC ECO:0000256|RuleBase:RU003753}.
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DR EMBL; AY617117; AAT36642.1; -; mRNA.
DR RefSeq; NP_001117054.1; NM_001123582.1.
DR STRING; 8030.ENSSSAP00000047024; -.
DR PaxDb; 8030-ENSSSAP00000047024; -.
DR Ensembl; ENSSSAT00000074196; ENSSSAP00000047024; ENSSSAG00000047946.
DR GeneID; 100136449; -.
DR KEGG; sasa:100136449; -.
DR OMA; DEHITDF; -.
DR OrthoDB; 4264279at2759; -.
DR Proteomes; UP000087266; Chromosome ssa24.
DR Bgee; ENSSSAG00000047946; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR10078:SF30; INTERLEUKIN-1 BETA; 1.
DR PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR Pfam; PF00340; IL1; 1.
DR PRINTS; PR00264; INTERLEUKIN1.
DR PRINTS; PR01359; INTRLEUKIN1B.
DR PRINTS; PR01357; INTRLEUKN1AB.
DR SMART; SM00125; IL1; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
PE 2: Evidence at transcript level;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Secreted {ECO:0000256|RuleBase:RU003753}.
SQ SEQUENCE 260 AA; 29176 MW; 896C730EEF9104A3 CRC64;
MEFESNYSLI KNTSESKAWS SKLPQGLDLE VSHHPITMRH IANLIIAMER LKGGEGVTMG
TEFKDKDLLN FLLESAVEEH IVLELESAPP TSRREAGFSS TSQYECSVTD SENKCWVLMS
EAMELHAMML QGGSGYHKVH LNLSTYVTPV PIETKARPVA LGIKGSNLYL SCSKSGGRPT
LHLEEVANKE QLKSISQQSD MVRFLFYRRN TGVDISTLES AGFRNWFIST DMQQDNTKPV
DMCQKAAPNR LTTFTIQRHN
//
