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Database: UniProt
Entry: Q6K431
LinkDB: Q6K431
Original site: Q6K431 
ID   TRX1_ORYSJ              Reviewed;        1022 AA.
AC   Q6K431; Q6K430;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   10-APR-2019, entry version 141.
DE   RecName: Full=Histone-lysine N-methyltransferase TRX1 {ECO:0000305};
DE            Short=OsTrx1 {ECO:0000303|PubMed:24420930};
DE            EC=2.1.1.43 {ECO:0000269|PubMed:24420930};
DE   AltName: Full=Protein SET DOMAIN GROUP 723 {ECO:0000305};
DE   AltName: Full=SET family protein 33 {ECO:0000305};
DE            Short=OsSET33 {ECO:0000303|PubMed:23762371};
GN   Name=TRX1 {ECO:0000303|PubMed:24420930};
GN   Synonyms=SDG723 {ECO:0000305}, SET {ECO:0000303|PubMed:23762371};
GN   OrderedLocusNames=Os09g0134500 {ECO:0000312|EMBL:BAF24549.1},
GN   LOC_Os09g04890 {ECO:0000305};
GN   ORFNames=P0406E03.49-1 {ECO:0000312|EMBL:BAD22318.1},
GN   P0406E03.49-2 {ECO:0000312|EMBL:BAD22319.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
RA   McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
RA   Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
RA   Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
RA   Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using
RT   next generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=23762371; DOI=10.1371/journal.pone.0065426;
RA   Lu Z., Huang X., Ouyang Y., Yao J.;
RT   "Genome-wide identification, phylogenetic and co-expression analysis
RT   of OsSET gene family in rice.";
RL   PLoS ONE 8:E65426-E65426(2013).
RN   [6]
RP   FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH EHD3, SUBCELLULAR
RP   LOCATION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=24420930; DOI=10.1104/pp.113.228049;
RA   Choi S.C., Lee S., Kim S.R., Lee Y.S., Liu C., Cao X., An G.;
RT   "Trithorax group protein Oryza sativa Trithorax1 controls flowering
RT   time in rice via interaction with early heading date3.";
RL   Plant Physiol. 164:1326-1337(2014).
CC   -!- FUNCTION: Possesses histone H3 methyltransferase activity in vitro
CC       (PubMed:24420930). Methylates 'Lys-4' of histone H3. H3 'Lys-4'
CC       methylation represents a specific tag for epigenetic
CC       transcriptional activation. Functions as a receptor for the lipid
CC       messenger phosphatidylinositol 5-phosphate (PI5P), which regulates
CC       negatively its transcriptional activation activity (By
CC       similarity). Involved in the regulation of flowering time and
CC       floral induction under long day (LD) conditions. Acts as an
CC       activator of flowering under LD conditions. May function through
CC       binding to EHD3, a repressor of GHD7 (PubMed:24420930).
CC       {ECO:0000250|UniProtKB:Q9C5X4, ECO:0000269|PubMed:24420930}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000269|PubMed:24420930};
CC   -!- SUBUNIT: Interacts with EHD3. {ECO:0000269|PubMed:24420930}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24420930}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6K431-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6K431-2; Sequence=VSP_058520, VSP_058521;
CC         Note=No experimental confirmation available. {ECO:0000305};
CC   -!- TISSUE SPECIFICITY: Expressed in leaf blades and panicles.
CC       {ECO:0000269|PubMed:24420930}.
CC   -!- DISRUPTION PHENOTYPE: Late-flowering phenotype under long day (LD)
CC       conditions. {ECO:0000269|PubMed:24420930}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. TRX/MLL subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
DR   EMBL; AP005583; BAD22318.1; -; Genomic_DNA.
DR   EMBL; AP005583; BAD22319.1; -; Genomic_DNA.
DR   EMBL; AP008215; BAF24549.1; -; Genomic_DNA.
DR   EMBL; AP014965; BAT06966.1; -; Genomic_DNA.
DR   EMBL; AP014965; BAT06967.1; -; Genomic_DNA.
DR   EMBL; AK065095; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK074022; BAG93767.1; -; mRNA.
DR   RefSeq; XP_015612383.1; XM_015756897.1. [Q6K431-1]
DR   UniGene; Os.7059; -.
DR   ProteinModelPortal; Q6K431; -.
DR   SMR; Q6K431; -.
DR   STRING; 4530.OS09T0134500-02; -.
DR   PaxDb; Q6K431; -.
DR   EnsemblPlants; Os09t0134500-01; Os09t0134500-01; Os09g0134500. [Q6K431-2]
DR   EnsemblPlants; Os09t0134500-02; Os09t0134500-02; Os09g0134500. [Q6K431-1]
DR   GeneID; 4346464; -.
DR   Gramene; Os09t0134500-01; Os09t0134500-01; Os09g0134500. [Q6K431-2]
DR   Gramene; Os09t0134500-02; Os09t0134500-02; Os09g0134500. [Q6K431-1]
DR   KEGG; osa:4346464; -.
DR   eggNOG; KOG1080; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   eggNOG; COG5141; LUCA.
DR   HOGENOM; HOG000030783; -.
DR   InParanoid; Q6K431; -.
DR   OMA; DQRLPCY; -.
DR   OrthoDB; 181572at2759; -.
DR   Reactome; R-OSA-3214841; PKMTs methylate histone lysines.
DR   Proteomes; UP000059680; Chromosome 9.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042054; F:histone methyltransferase activity; IDA:UniProtKB.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0048578; P:positive regulation of long-day photoperiodism, flowering; IMP:UniProtKB.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR034732; EPHD.
DR   InterPro; IPR003889; FYrich_C.
DR   InterPro; IPR003888; FYrich_N.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF05965; FYRC; 1.
DR   Pfam; PF05964; FYRN; 1.
DR   Pfam; PF00855; PWWP; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00542; FYRC; 1.
DR   SMART; SM00541; FYRN; 1.
DR   SMART; SM00249; PHD; 2.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00293; PWWP; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00333; TUDOR; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS51543; FYRC; 1.
DR   PROSITE; PS51542; FYRN; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50812; PWWP; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Chromatin regulator; Complete proteome;
KW   Flowering; Metal-binding; Methyltransferase; Nucleus;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase; Zinc;
KW   Zinc-finger.
FT   CHAIN         1   1022       Histone-lysine N-methyltransferase TRX1.
FT                                /FTId=PRO_0000437438.
FT   DOMAIN      264    327       PWWP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00162}.
FT   DOMAIN      402    461       FYR N-terminal. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00875}.
FT   DOMAIN      465    548       FYR C-terminal. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00876}.
FT   DOMAIN      861    979       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   DOMAIN      985   1001       Post-SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   ZN_FING     553    609       Phorbol-ester/DAG-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00226}.
FT   ZN_FING     564    615       PHD-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00146}.
FT   COMPBIAS     34     80       Pro-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00015}.
FT   METAL       943    943       Zinc. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   METAL       989    989       Zinc. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   METAL       991    991       Zinc. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   METAL       996    996       Zinc. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   BINDING     978    978       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00190}.
FT   VAR_SEQ     869    873       RIHGF -> INLYQ (in isoform 2).
FT                                /FTId=VSP_058520.
FT   VAR_SEQ     874   1022       Missing (in isoform 2).
FT                                /FTId=VSP_058521.
SQ   SEQUENCE   1022 AA;  115660 MW;  121B74C4998D773A CRC64;
     MVIAVEGGFV HEEEEVDHPI RYLPLGRVYS SSAPCPLPKK PRSAEDGKPP VIVYYRRRRK
     KPRVEGPPPS PATAPPMLHP REDDEDEEVT RRKGSLKYEL LSLGQAPPAL GGDGEEPARR
     RCLRRSGGAE RRGYFSEPKR RQRQGVHKEA ASSAGRRWLE LEIEAADPLA FVGLGCKVFW
     PLDEDWYKGS ITGYNEATKK HSVKYDDGES EDLNLADERI KFSISSEEMK CRNLKFGISN
     LNKRGYDELL ALAVSLHDYQ GLDPGDLVWA KLTGHAMWPA VVVDESNVPA NRALKPGRLD
     QSILVQFFGT HDFARIKLKQ AVPFLNGLLS SLHLKCKQAR FYRSLEEAKE FLCTQLLPEN
     MLQLQKSMEK GSSDANSNKD VHSCDNLSED KTAESGGDYD EMTPIELGNL RVSKLGRIVT
     DSDYFHNKKH IWPEGYTAFR KFRSVKDPHV VILYKMEVLR NSDIKARPLF RVTSEDGTQI
     DGSTPNTCWK EIYCRLKEKQ RNVASGLDRD VCQGSGSYMF GFSNPQIRQL IQELPNARSC
     LKYFENAGDT FRGYRAVHVN WKDLDYCSVC DMDEEYEDNL FLQCDKCRMM VHARCYGELE
     PLNGVLWLCN LCRPEAPRVS PRCCLCPVTG GAMKPTTDGR WAHLACAIWI PETCLKDVKR
     MEPIDGLSRI NKDRWKLLCS ICGVAYGACI QCSHPTCRVA YHPLCARAAD LCVELEDDDK
     IHLMLLDEDE DPCIRLLSYC KKHRQPSTER PSLESNLAKP AVVVQTDAVP PSGCARTEPY
     NIHGRRGQKQ PQVMATASVK RLYVENMPYI VSGFCQNRVG HDAISEPIQS VGFLDVAHQE
     AVGNVSSMIE KYKSMKATFR RRLAFGKSRI HGFGVFAKVS HKAGDMMIEY IGELVRPPIS
     DIRERRIYNS LVGAGTYMFR IDDERVIDAT RAGSIAHLIN HSCEPNCYSR VISVLGDEHI
     IIFAKRDINP WEELTYDYRF VSSDQRLPCY CGFPKCRGVV NDVEAEGQSA KIRVNRSELF
     QQ
//
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