ID Q6L6R7_WHEAT Unreviewed; 557 AA.
AC Q6L6R7;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=WNdr1B {ECO:0000313|EMBL:BAD19067.1};
GN Synonyms=WNdr1D {ECO:0000313|EMBL:BAD19066.1};
GN ORFNames=CFC21_008171 {ECO:0000313|EMBL:KAF6991045.1}, CFC21_013078
GN {ECO:0000313|EMBL:KAF6996775.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EMBL:BAD19067.1};
RN [1] {ECO:0000313|EMBL:BAD19067.1}
RP NUCLEOTIDE SEQUENCE.
RA Imai T., Terachi T.;
RT "Cloning and Structural Analysis of Wheat cDNAs Encoding Ndr Protein Kinase
RT Homolog by Data Mining of the EST Database KOMUGI.";
RL Breed. Sci. 55:207-212(2005).
RN [2] {ECO:0000313|EMBL:AJK31583.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26220083; DOI=10.1093/jxb/erv367;
RA Zhu X., Yang K., Wei X., Zhang Q., Rong W., Du L., Ye X., Qi L., Zhang Z.;
RT "The wheat AGC kinase TaAGC1 is a positive contributor to host resistance
RT to the necrotrophic pathogen Rhizoctonia cerealis.";
RL J. Exp. Bot. 66:6591-6603(2015).
RN [3] {ECO:0000313|EMBL:KAF6991045.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6991045.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [4] {ECO:0000313|EnsemblPlants:TraesCS1B02G344100.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS1B02G344100.4};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [5] {ECO:0000313|EnsemblPlants:TraesCS1B02G344100.4}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [6] {ECO:0000313|EMBL:KAF6991045.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6991045.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; KJ686386; AJK31583.1; -; mRNA.
DR EMBL; AB179753; BAD19066.1; -; mRNA.
DR EMBL; AB179754; BAD19067.1; -; mRNA.
DR EMBL; CM022212; KAF6991045.1; -; Genomic_DNA.
DR EMBL; CM022213; KAF6996775.1; -; Genomic_DNA.
DR SMR; Q6L6R7; -.
DR PaxDb; 4565-Traes_1BL_8331B9643-1; -.
DR EnsemblPlants; TraesCS1B02G344100.4; TraesCS1B02G344100.4; TraesCS1B02G344100.
DR EnsemblPlants; TraesCS1D02G332900.4; TraesCS1D02G332900.4; TraesCS1D02G332900.
DR Gramene; TraesCS1B02G344100.4; TraesCS1B02G344100.4; TraesCS1B02G344100.
DR Gramene; TraesCS1B03G0945100.3; TraesCS1B03G0945100.3.CDS; TraesCS1B03G0945100.
DR Gramene; TraesCS1D02G332900.4; TraesCS1D02G332900.4; TraesCS1D02G332900.
DR Gramene; TraesCS1D03G0789600.5; TraesCS1D03G0789600.5.CDS; TraesCS1D03G0789600.
DR Gramene; TraesKAR1B01G0375620.1; cds.TraesKAR1B01G0375620.1; TraesKAR1B01G0375620.
DR Gramene; TraesKAR1D01G0305230.1; cds.TraesKAR1D01G0305230.1; TraesKAR1D01G0305230.
DR Gramene; TraesRN1B0100964000.3; TraesRN1B0100964000.3; TraesRN1B0100964000.
DR Gramene; TraesRN1D0100835800.5; TraesRN1D0100835800.5; TraesRN1D0100835800.
DR Gramene; TraesRN1D0100835900.1; TraesRN1D0100835900.1; TraesRN1D0100835900.
DR eggNOG; KOG0605; Eukaryota.
DR HOGENOM; CLU_000288_67_0_1; -.
DR OrthoDB; 988261at2759; -.
DR Proteomes; UP000019116; Chromosome 1B.
DR Proteomes; UP000019116; Chromosome 1D.
DR Proteomes; UP000815260; Chromosome 1B.
DR Proteomes; UP000815260; Chromosome 1D.
DR ExpressionAtlas; Q6L6R7; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd21742; MobB_NDR_LATS-like; 1.
DR CDD; cd05599; STKc_NDR_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24356:SF184; SERINE_THREONINE-PROTEIN KINASE TRICORNERED; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00433; Pkinase_C; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAD19067.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 116..421
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 422..494
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 145
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 557 AA; 64147 MW; 9B0BA2F94BABB67A CRC64;
MDSARSWFQK FQPRDKSKSP AVPASHGKDP GKPPVDDAPS SATKQKVAAA KQYIENHYKT
QMKSLQDRKE RRWMLERKLQ DAEVPAEEQN NILKHLEKKE TEYMRLQRHK MGVEDFELLT
IIGRGAFGEV RLCREKTSKS VYAMKKLKKS EMLRRGQVEH VKAERNLLAE VDSAYIVKLY
YSFQDDEFLY LIMEYLPGGD MMTLLMRKDT LTEDEAKFYI AETVLAIESI HKHNYIHRDI
KPDNLLLDLS GHLKLSDFGL CKPLDSSNFP NLNEPDYTPG KGAKPLPDNT SRLTNSSAPK
RTQQEQLSHW QKNRRMLAYS TVGTPDYIAP EVLLKKGYGM ECDWWSLGAI MYEMLVGYPP
FYSEDPMSTC RKIVNWRSHL KFPEEAKLSS ETKDLISKLL CNVEQRLGTK GAHEIKAHTW
FRGVQWEKLY QMKAAFIPEV NGELDTQNFE KFEETGAQVQ SSSKAGPWRK MLPSKDANFV
GYTYKNFEIV NDDEVAGIAE LKKKSSKSKR PTIKTLFESM DEDEPVHGSF LNMLPHKEGQ
PSSHSSAPPE QYQPRRK
//
