ID Q6LKU1_PHOPR Unreviewed; 638 AA.
AC Q6LKU1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=TTRS {ECO:0000313|EMBL:CAG21880.1};
GN OrderedLocusNames=PBPRB0007 {ECO:0000313|EMBL:CAG21880.1};
OS Photobacterium profundum (strain SS9).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Photobacterium.
OX NCBI_TaxID=298386 {ECO:0000313|EMBL:CAG21880.1, ECO:0000313|Proteomes:UP000000593};
RN [1] {ECO:0000313|Proteomes:UP000000593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1253 / SS9 {ECO:0000313|Proteomes:UP000000593};
RX PubMed=15746425; DOI=10.1126/science.1103341;
RA Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M.,
RA Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C.,
RA Bartlett D.H., Valle G.;
RT "Life at depth: Photobacterium profundum genome sequence and expression
RT analysis.";
RL Science 307:1459-1461(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CR378675; CAG21880.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6LKU1; -.
DR STRING; 298386.PBPRB0007; -.
DR KEGG; ppr:PBPRB0007; -.
DR eggNOG; COG3221; Bacteria.
DR eggNOG; COG4191; Bacteria.
DR HOGENOM; CLU_011260_3_0_6; -.
DR Proteomes; UP000000593; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF12974; Phosphonate-bd; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CAG21880.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000593};
KW Transferase {ECO:0000313|EMBL:CAG21880.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 407..634
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 638 AA; 71677 MW; 68968F1DE682538F CRC64;
MPSIKRVTQK NKPQNKQKSC VAGGYWLNVI GYSVVTLAAI AFSHTIFAKD PQSADSAFNQ
KIDVGILATR GNLEALNRWQ PTMDWLERKI PNTEFVLYPY TLEQMTEAVK AQTVDFVITN
PGQSVLLGRQ YPLSWLATLR SQQQGGTTLA IGSALVVRND SSYFTLTDLD NQPVAAVSDS
AFGGYLTLRR KMQQRSLDPN RFFSTVDFIG FPLDAILYKL RDKHVEAAVL PVCQLETMGR
EGLIDFSQYR VLDNQAPVGF GCQVSTALYP NWSFAKTGKA SETLAKQIAR ALLDLPERDP
AAIAAHSLGW SAPISQLKID KLYQDLDLHP LQKPWWQEAF TWLKSNQQWG WTFLLFVVVL
NLYHFLLEYR FSRNQRLLIA TQNRLKEKNA MLEHAQRVAI VGELGGSIAH EINQPLSAIR
NYSQGGLVRI NKGSSADDLK VVLEKIQQQV IRADDIVQRL RSLIKKRPIN KQYSNVQALI
TDAVMLLDHD LIKHQITLSM TESGQVVPVY LDPIGFQQLL LNLVKNAMDA CVLDHQKQRV
QELHTQEKYQ IVIHTEYLPV EKQMKLVVTD NGNGIGLEAD TALLQSAFFT TKEEGLGLGL
AICRDVVEDH HGTLTMASNS PHGCRIEVRL PYIGNTEN
//
