ID Q6M0U4_METMP Unreviewed; 458 AA.
AC Q6M0U4;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=HD phosphohydrolase family member {ECO:0000313|EMBL:CAF29730.1};
GN OrderedLocusNames=MMP0174 {ECO:0000313|EMBL:CAF29730.1};
OS Methanococcus maripaludis (strain S2 / LL).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=267377 {ECO:0000313|Proteomes:UP000000590};
RN [1] {ECO:0000313|EMBL:CAF29730.1, ECO:0000313|Proteomes:UP000000590}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 / LL {ECO:0000313|Proteomes:UP000000590};
RX PubMed=15466049; DOI=10.1128/JB.186.20.6956-6969.2004;
RA Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soll D.,
RA Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA Olson M.V., Leigh J.A.;
RT "Complete genome sequence of the genetically tractable hydrogenotrophic
RT methanogen Methanococcus maripaludis.";
RL J. Bacteriol. 186:6956-6969(2004).
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DR EMBL; BX950229; CAF29730.1; -; Genomic_DNA.
DR RefSeq; WP_011170118.1; NC_005791.1.
DR AlphaFoldDB; Q6M0U4; -.
DR STRING; 267377.MMP0174; -.
DR EnsemblBacteria; CAF29730; CAF29730; MMP0174.
DR GeneID; 2761347; -.
DR KEGG; mmp:MMP0174; -.
DR PATRIC; fig|267377.15.peg.178; -.
DR eggNOG; arCOG04430; Archaea.
DR HOGENOM; CLU_026821_3_2_2; -.
DR OrthoDB; 8895at2157; -.
DR Proteomes; UP000000590; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR045509; HD_assoc_2.
DR InterPro; IPR006674; HD_domain.
DR PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF19276; HD_assoc_2; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CAF29730.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000590}.
FT DOMAIN 53..151
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 458 AA; 52470 MW; CAC35049C5EA3E0F CRC64;
MSKLKIIRDP IHKDIKLNEE EISIVDMPEI QRLRNIKQTG LTCLVYPSAN HTRFEHSIGT
MHVAGEIAKN LENIDKNLTK IVALLHDIGH PPFSHTLEVA GYDHEEFTKE KIKRMNFENY
TSKEVLDVYS SKGLEGSLIH GDVDADRMDY LVRDSHHTGV AYGSIDIPRL IRSIVVIEDT
NKLGIIEKGR TTVESLLTAR YQMYPTVYMH PTSRISETMI KNATIDAIKD DIFKLRDLSL
MDDIDLICTL RRSEGSSNEI MRKIDKRDLF KSISVQRYNE LSPKERWNLI NLSENELGII
ENEMSDFFGS RIFLDIPKPP KMAEHRITVI MGDKKQRLDE ISPLAESLKD AYKKSWSVMV
YSEPETAKKS SEIVKDKNKF LFDFISDEII DNSILNVLNE QGTVQGVTKL AGLVKKSPND
TEFHSELQKL IFCGLVDKKV EPVRGTYRYD YTAAKLDD
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