ID Q6MFY2_RAT Unreviewed; 330 AA.
AC Q6MFY2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 165.
DE SubName: Full=RT1 class I, M6, gene 1 {ECO:0000313|EMBL:CAE84065.1};
GN Name=RT1-M6-1 {ECO:0000313|RGD:1598232};
GN Synonyms=9430032L10Rik {ECO:0000313|RGD:1598232}, Gabbr1
GN {ECO:0000313|RGD:1598232}, Mog {ECO:0000313|RGD:1598232},
GN Olr1735_predicted {ECO:0000313|RGD:1598232}, Olr1736_predicted
GN {ECO:0000313|RGD:1598232}, Olr1737_predicted
GN {ECO:0000313|RGD:1598232}, Olr1738_predicted
GN {ECO:0000313|RGD:1598232}, Olr1739_predicted
GN {ECO:0000313|RGD:1598232}, Olr1742_predicted
GN {ECO:0000313|RGD:1598232}, Olr1743_predicted
GN {ECO:0000313|RGD:1598232}, Olr1744_predicted
GN {ECO:0000313|RGD:1598232}, Olr1745_predicted
GN {ECO:0000313|RGD:1598232}, Olr1746_predicted
GN {ECO:0000313|RGD:1598232}, Olr1748_predicted
GN {ECO:0000313|RGD:1598232}, Olr1749_predicted
GN {ECO:0000313|RGD:1598232}, Olr1750_predicted
GN {ECO:0000313|RGD:1598232}, Rps15-ps {ECO:0000313|RGD:1598232}, RT1-M3
GN {ECO:0000313|RGD:1598232}, RT1-M3-2 {ECO:0000313|RGD:1598232}, Ubd
GN {ECO:0000313|RGD:1598232}, Zfp57 {ECO:0000313|RGD:1598232}, Znrd1
GN {ECO:0000313|RGD:1598232};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE84065.1};
RN [1] {ECO:0000313|EMBL:CAE84065.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84065.1};
RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A.,
RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H.,
RA Sudbrak R., Reinhardt R.;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAE84065.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84065.1};
RX PubMed=15060004; DOI=10.1101/gr.1987704;
RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT "The genomic sequence and comparative analysis of the rat major
RT histocompatibility complex.";
RL Genome Res. 14:631-639(2004).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system. {ECO:0000256|ARBA:ARBA00002297}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|ARBA:ARBA00006909}.
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DR EMBL; BX883052; CAE84065.1; -; Genomic_DNA.
DR RefSeq; NP_001008852.1; NM_001008852.1.
DR AlphaFoldDB; Q6MFY2; -.
DR SMR; Q6MFY2; -.
DR GeneID; 414785; -.
DR KEGG; rno:414785; -.
DR UCSC; RGD:1598232; rat.
DR AGR; RGD:1598232; -.
DR CTD; 414785; -.
DR RGD; 1598232; RT1-M6-1.
DR HOGENOM; CLU_047501_1_1_1; -.
DR OrthoDB; 3840485at2759; -.
DR Bgee; ENSRNOG00000022107; Expressed in testis and 19 other cell types or tissues.
DR ExpressionAtlas; Q6MFY2; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt.
DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IBA:GO_Central.
DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IBA:GO_Central.
DR CDD; cd12087; TM_EGFR-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR PANTHER; PTHR16675:SF242; CLASS IB MHC ANTIGEN QA-2-RELATED; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022451};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW MHC I {ECO:0000256|ARBA:ARBA00022451};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 330 AA; 36963 MW; D34F7CC4D741217E CRC64;
MGAPVLHATL LLLSAFLALT QTKNQSFAGS HFMQYLVTTT SSQPGLQDSH VCIVGHVDYM
PFMRFDSDGA AQRIQTRGPW MKQMGPEYLE MERKNAEGYS HRARENLRFA IQVYNQSDKA
HYSHAFDGQH YISLNSDLTT WSVGDSTAQI TKRRWEADGV AEALSHFLKV SCVEHLQKHL
ETGKETLQRS DPPKAHVTLH PRPEGDVTLR CWALGFYPAD ITLTWQLNGE DLTQDMELVE
TRPAGDGTFQ KWASVVVPNG EEQKYTCLVE HEGLPEPLTL RWKPATWPVV GITVGVVLLG
FVIIGALIAI VTMRKKRADP VDPVDLMDPV
//
