GenomeNet

Database: UniProt
Entry: Q6MG84
LinkDB: Q6MG84
Original site: Q6MG84 
ID   EGFL8_RAT               Reviewed;         291 AA.
AC   Q6MG84; A0JPK1;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   16-JAN-2019, entry version 104.
DE   RecName: Full=Epidermal growth factor-like protein 8;
DE            Short=EGF-like protein 8;
DE   Flags: Precursor;
GN   Name=Egfl8; Synonyms=Ng3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15060004; DOI=10.1101/gr.1987704;
RA   Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T.,
RA   Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT   "The genomic sequence and comparative analysis of the rat major
RT   histocompatibility complex.";
RL   Genome Res. 14:631-639(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6MG84-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6MG84-2; Sequence=VSP_026673;
DR   EMBL; BX883044; CAE83962.1; -; Genomic_DNA.
DR   EMBL; BC127463; AAI27464.1; -; mRNA.
DR   RefSeq; NP_001004070.1; NM_001004070.2. [Q6MG84-1]
DR   RefSeq; NP_001159352.1; NM_001165880.1. [Q6MG84-2]
DR   RefSeq; XP_006256040.1; XM_006255978.3. [Q6MG84-1]
DR   RefSeq; XP_006256041.1; XM_006255979.3. [Q6MG84-1]
DR   RefSeq; XP_017457200.1; XM_017601711.1. [Q6MG84-1]
DR   RefSeq; XP_017457201.1; XM_017601712.1. [Q6MG84-1]
DR   UniGene; Rn.146030; -.
DR   ProteinModelPortal; Q6MG84; -.
DR   SMR; Q6MG84; -.
DR   STRING; 10116.ENSRNOP00000000499; -.
DR   PaxDb; Q6MG84; -.
DR   PRIDE; Q6MG84; -.
DR   Ensembl; ENSRNOT00000000499; ENSRNOP00000000499; ENSRNOG00000000436. [Q6MG84-1]
DR   Ensembl; ENSRNOT00000068712; ENSRNOP00000063796; ENSRNOG00000000436. [Q6MG84-2]
DR   GeneID; 406166; -.
DR   KEGG; rno:406166; -.
DR   UCSC; RGD:1549706; rat. [Q6MG84-1]
DR   CTD; 80864; -.
DR   RGD; 1549706; Egfl8.
DR   eggNOG; ENOG410IR79; Eukaryota.
DR   eggNOG; ENOG41129FY; LUCA.
DR   GeneTree; ENSGT00940000162975; -.
DR   HOGENOM; HOG000231494; -.
DR   HOVERGEN; HBG051453; -.
DR   InParanoid; Q6MG84; -.
DR   OMA; TCSCEDN; -.
DR   OrthoDB; 749722at2759; -.
DR   PhylomeDB; Q6MG84; -.
DR   PRO; PR:Q6MG84; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000000436; Expressed in 9 organ(s), highest expression level in adult mammalian kidney.
DR   Genevisible; Q6MG84; RN.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR011489; EMI_domain.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF07546; EMI; 1.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00179; EGF_CA; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS51041; EMI; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Calcium; Coiled coil; Complete proteome;
KW   Disulfide bond; EGF-like domain; Glycoprotein; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL        1     27       {ECO:0000255}.
FT   CHAIN        28    291       Epidermal growth factor-like protein 8.
FT                                /FTId=PRO_0000007533.
FT   DOMAIN       33    111       EMI. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00384}.
FT   DOMAIN      110    141       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      143    183       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   COILED      198    231       {ECO:0000255}.
FT   CARBOHYD     49     49       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     37     96       {ECO:0000250}.
FT   DISULFID     64     70       {ECO:0000250}.
FT   DISULFID     95    109       {ECO:0000250}.
FT   DISULFID    113    123       {ECO:0000250}.
FT   DISULFID    117    129       {ECO:0000250}.
FT   DISULFID    131    140       {ECO:0000250}.
FT   DISULFID    147    158       {ECO:0000250}.
FT   DISULFID    154    167       {ECO:0000250}.
FT   DISULFID    169    182       {ECO:0000250}.
FT   VAR_SEQ     279    291       SCEDNSLGPGLHG -> ESPAPPP (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_026673.
SQ   SEQUENCE   291 AA;  31667 MW;  FF4D326339ABC730 CRC64;
     MEPWAGCCIF LRGFSFLLVL MTEGAKGGPF KESLGVCSKQ TLLVPLRYNE SYSQPVYRPY
     LTLCAGRRIC STYRTTYRVA WREVRREVQQ THVVCCQGWK KPHPGALTCE AICSKPCLNG
     GVCAGPDQCE CASGWAGKHC HVDVDECRTS LTLCSHGCLN TLGSFTCSCP NPLVLGPDGR
     ACAGGPPESS TSAGILSVAV READSEEHAL RREVAELRGR LERLEQWATQ AGAWVRAVLP
     VAPEDLRPEQ VAELWGRGDR IESLSDQVLL LEERLGACSC EDNSLGPGLH G
//
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