ID Q6MGB8_RAT Unreviewed; 366 AA.
AC Q6MGB8; F7ERG5;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 183.
DE SubName: Full=RT1 class I, A2 {ECO:0000313|EMBL:CAE83928.1};
DE SubName: Full=RT1 class Ia, A2n {ECO:0000313|EMBL:AVP72126.1};
DE SubName: Full=RT1 class Ia, locus A2 {ECO:0000313|EMBL:AAH88465.1};
GN Name=RT1-A2 {ECO:0000313|EMBL:CAE83928.1, ECO:0000313|RGD:1595923};
GN Synonyms=AA926063 {ECO:0000313|RGD:1595923}, B3galt4
GN {ECO:0000313|RGD:1595923}, Cdk2ap1-ps1 {ECO:0000313|RGD:1595923},
GN Col11a2 {ECO:0000313|RGD:1595923}, Daxx {ECO:0000313|RGD:1595923},
GN Hsd17b8 {ECO:0000313|RGD:1595923}, Kifc1 {ECO:0000313|RGD:1595923},
GN LOC224733l-1 {ECO:0000313|RGD:1595923}, LOC224733l-2
GN {ECO:0000313|RGD:1595923}, Phf1 {ECO:0000313|RGD:1595923}, Rps25-ps1
GN {ECO:0000313|RGD:1595923}, RT1-A1 {ECO:0000313|RGD:1595923}, RT1-A2n
GN {ECO:0000313|EMBL:AVP72126.1}, RT1-A3 {ECO:0000313|RGD:1595923},
GN RT1-DOa {ECO:0000313|RGD:1595923}, RT1-Hb {ECO:0000313|RGD:1595923},
GN RT1-Ke4 {ECO:0000313|RGD:1595923}, Rxrb {ECO:0000313|RGD:1595923},
GN Sacm2l-ps1 {ECO:0000313|RGD:1595923}, Sacm2l-ps2
GN {ECO:0000313|RGD:1595923}, Sec61-ps {ECO:0000313|RGD:1595923}, Syngap1
GN {ECO:0000313|RGD:1595923};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE83928.1};
RN [1] {ECO:0000313|EMBL:CAE83928.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83928.1};
RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A.,
RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H.,
RA Sudbrak R., Reinhardt R.;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAE83928.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83928.1};
RX PubMed=15060004; DOI=10.1101/gr.1987704;
RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT "The genomic sequence and comparative analysis of the rat major
RT histocompatibility complex.";
RL Genome Res. 14:631-639(2004).
RN [3] {ECO:0000313|EMBL:AAH88465.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000313|EMBL:AAH88465.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000313|EMBL:AVP72126.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29531166;
RA Dai K.Z., Ryan J.C., Naper C., Vaage J.T.;
RT "Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49
RT Receptors and Induction of Potent NK Cell Alloresponses in Rats.";
RL J. Immunol. 200:2847-2859(2018).
RN [5] {ECO:0000313|EMBL:AVP72126.1}
RP NUCLEOTIDE SEQUENCE.
RA Cohen D.B., Kent A.D.;
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system. {ECO:0000256|ARBA:ARBA00002297}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC088465; AAH88465.1; -; mRNA.
DR EMBL; MG963096; AVP72126.1; -; mRNA.
DR EMBL; BX883042; CAE83928.1; -; Genomic_DNA.
DR RefSeq; NP_001008829.1; NM_001008829.1.
DR AlphaFoldDB; Q6MGB8; -.
DR SMR; Q6MGB8; -.
DR IntAct; Q6MGB8; 1.
DR PaxDb; 10116-ENSRNOP00000050701; -.
DR GeneID; 24974; -.
DR KEGG; rno:24974; -.
DR AGR; RGD:1595923; -.
DR CTD; 24974; -.
DR RGD; 1595923; RT1-A2.
DR VEuPathDB; HostDB:ENSRNOG00000066181; -.
DR eggNOG; ENOG502RQEK; Eukaryota.
DR HOGENOM; CLU_047501_1_1_1; -.
DR InParanoid; Q6MGB8; -.
DR OrthoDB; 3840485at2759; -.
DR TreeFam; TF336617; -.
DR Reactome; R-RNO-1236974; ER-Phagosome pathway.
DR Reactome; R-RNO-1236977; Endosomal/Vacuolar pathway.
DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-RNO-2172127; DAP12 interactions.
DR Reactome; R-RNO-6798695; Neutrophil degranulation.
DR Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
DR Bgee; ENSRNOG00000030712; Expressed in jejunum and 19 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0042612; C:MHC class I protein complex; ISO:RGD.
DR GO; GO:0032398; C:MHC class Ib protein complex; ISO:RGD.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0030881; F:beta-2-microglobulin binding; ISO:RGD.
DR GO; GO:0042288; F:MHC class I protein binding; ISO:RGD.
DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; ISO:RGD.
DR GO; GO:0042605; F:peptide antigen binding; ISO:RGD.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0042608; F:T cell receptor binding; ISO:RGD.
DR GO; GO:0002250; P:adaptive immune response; ISO:RGD.
DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IBA:GO_Central.
DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; ISO:RGD.
DR GO; GO:0002489; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; ISO:RGD.
DR GO; GO:0002477; P:antigen processing and presentation of exogenous peptide antigen via MHC class Ib; ISO:RGD.
DR GO; GO:0036037; P:CD8-positive, alpha-beta T cell activation; ISO:RGD.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0048839; P:inner ear development; ISO:RGD.
DR GO; GO:0002519; P:natural killer cell tolerance induction; ISO:RGD.
DR GO; GO:0032815; P:negative regulation of natural killer cell activation; ISO:RGD.
DR GO; GO:0045953; P:negative regulation of natural killer cell mediated cytotoxicity; ISO:RGD.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0001815; P:positive regulation of antibody-dependent cellular cytotoxicity; ISO:RGD.
DR GO; GO:2001187; P:positive regulation of CD8-positive, alpha-beta T cell activation; ISO:RGD.
DR GO; GO:2000566; P:positive regulation of CD8-positive, alpha-beta T cell proliferation; ISO:RGD.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; ISO:RGD.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; ISO:RGD.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; ISO:RGD.
DR GO; GO:0032816; P:positive regulation of natural killer cell activation; ISO:RGD.
DR GO; GO:0002729; P:positive regulation of natural killer cell cytokine production; ISO:RGD.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; ISO:RGD.
DR GO; GO:0002717; P:positive regulation of natural killer cell mediated immunity; ISO:RGD.
DR GO; GO:0032819; P:positive regulation of natural killer cell proliferation; ISO:RGD.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; ISO:RGD.
DR GO; GO:0032759; P:positive regulation of TRAIL production; ISO:RGD.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:RGD.
DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; ISO:RGD.
DR GO; GO:0002715; P:regulation of natural killer cell mediated immunity; ISO:RGD.
DR GO; GO:0001913; P:T cell mediated cytotoxicity; ISO:RGD.
DR CDD; cd21015; IgC1_MHC_Ia_RT1-Aa; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR InterPro; IPR010579; MHC_I_a_C.
DR NCBIfam; NF041738; GG_III-CTERM; 1.
DR PANTHER; PTHR16675:SF242; CLASS IB MHC ANTIGEN QA-2-RELATED; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022451};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC I {ECO:0000256|ARBA:ARBA00022451}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..366
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015098372"
FT TRANSMEM 310..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 207..293
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 338..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 41393 MW; 92AD4D9EF21F1974 CRC64;
MMEPCTLLLL LAVALTPTQT RAGSHSLRYF VTAVSRPGLG EPRYMEVGYV DDTQFVRYDS
DAENPRYEPR APWMEREGPE YWERETQNAK RNEQVYRVDL RTALRYYNQS EGGSHTIQRM
YGCDMGSDGS LLRGYYQDAY DGRDYIALNE DLKTWTAADF AAQITRSKWD QAGVAERLRA
YLEGTCVEWL RRYLELGKET LLRSDPPEAH VTLHPRPEGD VTLRCWALGF YPADITLTWQ
LNGEDLTQDM ELVETRPAGD GTFQKWASVV VPLGKEQNYT CRVEHEGLPE PLSQRWEPSP
STNSNMETTV IYVVLGAIIG TLAIIGIVVA VVRKRRRNTG GKGDYTPAPG RDSSQSSDVS
LPDCKA
//
