ID Q6NG55_CORDI Unreviewed; 377 AA.
AC Q6NG55;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=RNase H type-1 domain-containing protein {ECO:0000259|PROSITE:PS50879};
GN OrderedLocusNames=DIP1678 {ECO:0000313|EMBL:CAE50207.1};
OS Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype
OS gravis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=257309 {ECO:0000313|EMBL:CAE50207.1, ECO:0000313|Proteomes:UP000002198};
RN [1] {ECO:0000313|EMBL:CAE50207.1, ECO:0000313|Proteomes:UP000002198}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700971 / NCTC 13129 / Biotype gravis
RC {ECO:0000313|Proteomes:UP000002198};
RX PubMed=14602910; DOI=10.1093/nar/gkg874;
RA Cerdeno-Tarraga A.M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.,
RA Bentley S.D., Besra G.S., Churcher C., James K.D., De Zoysa A.,
RA Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S.,
RA Jagels K., Moule S., Quail M.A., Rabbinowitsch E., Rutherford K.,
RA Thomson N.R., Unwin L., Whitehead S., Barrell B.G.Parkhill.J.;
RT "The complete genome sequence and analysis of Corynebacterium diphtheriae
RT NCTC13129.";
RL Nucleic Acids Res. 31:6516-6523(2003).
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DR EMBL; BX248358; CAE50207.1; -; Genomic_DNA.
DR RefSeq; WP_010935245.1; NC_002935.2.
DR AlphaFoldDB; Q6NG55; -.
DR STRING; 257309.DIP1678; -.
DR DNASU; 2648723; -.
DR KEGG; cdi:DIP1678; -.
DR HOGENOM; CLU_035712_0_0_11; -.
DR Proteomes; UP000002198; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR014636; RNaseH/PGlycerate_mutase.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR48100; BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED; 1.
DR PANTHER; PTHR48100:SF1; PHOSPHOGLYCERATE MUTASE PMU1-RELATED; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR PIRSF; PIRSF036922; RNaseH_PGAM; 1.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002198}.
FT DOMAIN 1..139
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT ACT_SITE 182
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 257
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 232
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 377 AA; 40860 MW; C6FE722D0CE33C3A CRC64;
MKVIIEADGG SRGNPGIAGS GTLIYNADRS QVLKEYSYVV GKATNNVAEY HGLLNGLRGA
AELGATEVSV RMDSKLVVEQ MSGRWKIKHP DMKELALECK KVASSIGSVS YEWIPRSENS
HADALANKAM DALAEGAAVG FLELEEPAAK TDSEEKVVET ATSPAVWNGA TTQATRFVLL
RHGQTAMSAA RQYSGRSNPE LTSVGLEQAR RAAAFIGRRG GIDAIVASPL QRCQQTAHEV
SEQLGGMPVR TIDGLIEMDF GQWDGLSFSQ AHEADPELHS AWLDDSRTAP PGGESLQQVH
RRVKKVREEL ERKYAGKTIV VVSHVTPIKS ILRQALDASA SMFHRMHLDL ASISVAEFYS
DGPTCVRSVN DTHYLYG
//
