ID Q6NYV7_DANRE Unreviewed; 1001 AA.
AC Q6NYV7; A0A8M1PKR2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE SubName: Full=Protocadherin 10a {ECO:0000313|EMBL:AAH66445.1, ECO:0000313|Ensembl:ENSDARP00000144991};
DE SubName: Full=Protocadherin-10 precursor {ECO:0000313|RefSeq:NP_997736.1};
GN Name=pcdh10a {ECO:0000313|EMBL:AAH66445.1,
GN ECO:0000313|Ensembl:ENSDARP00000144991,
GN ECO:0000313|RefSeq:NP_997736.1, ECO:0000313|ZFIN:ZDB-GENE-020731-1};
GN Synonyms=fc56b06 {ECO:0000313|RefSeq:NP_997736.1}, pcdh10
GN {ECO:0000313|RefSeq:NP_997736.1}, pcr1
GN {ECO:0000313|RefSeq:NP_997736.1}, wu:fc56b06
GN {ECO:0000313|RefSeq:NP_997736.1}, wu:fq40g12
GN {ECO:0000313|RefSeq:NP_997736.1}, ZPCR1
GN {ECO:0000313|RefSeq:NP_997736.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH66445.1};
RN [1] {ECO:0000313|EMBL:AAH66445.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH66445.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_997736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16109975;
RA Woods I.G., Wilson C., Friedlander B., Chang P., Reyes D.K., Nix R.,
RA Kelly P.D., Chu F., Postlethwait J.H., Talbot W.S.;
RT "The zebrafish gene map defines ancestral vertebrate chromosomes.";
RL Genome Res. 15:1307-1314(2005).
RN [3] {ECO:0000313|RefSeq:NP_997736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20107084;
RA Amo R., Aizawa H., Takahoko M., Kobayashi M., Takahashi R., Aoki T.,
RA Okamoto H.;
RT "Identification of the zebrafish ventral habenula as a homolog of the
RT mammalian lateral habenula.";
RL J. Neurosci. 30:1566-1574(2010).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000144991, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000144991};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_997736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26306682;
RA Mosimann C., Panakova D., Werdich A.A., Musso G., Burger A., Lawson K.L.,
RA Carr L.A., Nevis K.R., Sabeh M.K., Zhou Y., Davidson A.J., DiBiase A.,
RA Burns C.E., Burns C.G., MacRae C.A., Zon L.I.;
RT "Chamber identity programs drive early functional partitioning of the
RT heart.";
RL Nat. Commun. 6:8146-8146(2015).
RN [6] {ECO:0000313|RefSeq:NP_997736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25931248;
RA Esain V., Kwan W., Carroll K.J., Cortes M., Liu S.Y., Frechette G.M.,
RA Sheward L.M., Nissim S., Goessling W., North T.E.;
RT "Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell
RT Development via Prostaglandin E2 and P-Selectin Activity.";
RL Stem Cells 33:2596-2612(2015).
RN [7] {ECO:0000313|RefSeq:NP_997736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [8] {ECO:0000313|RefSeq:NP_997736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27756875;
RA Zhou X., Yue G.G., Liu M., Zuo Z., Lee J.K., Li M., Tsui S.K., Fung K.P.,
RA Sun H., Pu J., Lau C.B.;
RT "Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis
RT and diminished angiogenesis-dependent breast tumor growth by suppressing
RT VEGFR-2 signaling.";
RL Oncotarget 7:82820-82835(2016).
RN [9] {ECO:0000313|RefSeq:NP_997736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27615194;
RA Takeuchi M., Yamaguchi S., Sakakibara Y., Hayashi T., Matsuda K., Hara Y.,
RA Tanegashima C., Shimizu T., Kuraku S., Hibi M.;
RT "Gene expression profiling of granule cells and Purkinje cells in the
RT zebrafish cerebellum.";
RL J. Comp. Neurol. 525:1558-1585(2017).
RN [10] {ECO:0000313|RefSeq:NP_997736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29604249; DOI=10.1016/j.ydbio.2018.03.022;
RA Williams J.S., Hsu J.Y., Rossi C.C., Artinger K.B.;
RT "Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor
RT migration.";
RL Dev. Biol. 444 Suppl 1:S274-S286(2018).
RN [11] {ECO:0000313|Ensembl:ENSDARP00000144991}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000144991};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [12] {ECO:0000313|RefSeq:NP_997736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30695021;
RA Turner K.J., Hoyle J., Valdivia L.E., Cerveny K.L., Hart W., Mangoli M.,
RA Geisler R., Rees M., Houart C., Poole R.J., Wilson S.W., Gestri G.;
RT "Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure
RT of cells to transition from proliferation to differentiation, retinal
RT coloboma and midline axon guidance deficits.";
RL PLoS ONE 14:e0211073-e0211073(2019).
RN [13] {ECO:0000313|RefSeq:NP_997736.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU550698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FP340260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066445; AAH66445.1; -; mRNA.
DR RefSeq; NP_997736.1; NM_212571.1.
DR STRING; 7955.ENSDARP00000144991; -.
DR PaxDb; 7955-ENSDARP00000070915; -.
DR Ensembl; ENSDART00000180121.1; ENSDARP00000144991.1; ENSDARG00000099729.2.
DR GeneID; 259186; -.
DR KEGG; dre:259186; -.
DR AGR; ZFIN:ZDB-GENE-020731-1; -.
DR CTD; 259186; -.
DR ZFIN; ZDB-GENE-020731-1; pcdh10a.
DR OMA; RYAIHEE; -.
DR OrthoDB; 4259465at2759; -.
DR Proteomes; UP000000437; Chromosome 1.
DR Bgee; ENSDARG00000099729; Expressed in brain and 39 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0097324; P:melanocyte migration; IMP:ZFIN.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF334; PROTOCADHERIN 10A; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_997736.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1001
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_997736.1"
FT /id="PRO_5035036038"
FT TRANSMEM 678..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..120
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 121..229
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 230..337
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 338..442
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 443..552
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 566..656
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 852..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..882
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 110190 MW; CC39AB9DAF06456E CRC64;
MILIFLFFSI LDGGLSQLHF SVPEEQERGT VVGNIAEDLG LDITKLSARR FQTVPSSRTP
YLEVNLENGA LVVNERIDRE EICRQTVPCL LHLEVFLENP LELFRVEIEV MDINDNPPSF
PETDITVEIT ESATPGTRFP VENAFDPDVG TNALSTYAIT TNNYFYLDVQ TQGDGNRFAE
LVLDKPLDRE QQAIHKYVLT AVDGGQPQRT GTALLVVKVL DSNDNAPTFD QSVYSVSLRE
NSPVGTLVIQ LNASDMDEGQ NGEIVYSLSS HNSPRIRDLF NIDSRTGRIE VTGEVDYEES
STHQIYVQAK DMGPNAVPAH CKVLVKLIDV NDNTPEISFS TVTESVSEQA APGTVIALLS
VTDRDSGENG QMTCELHGEV PFKLKSSFKN YYTIVTDGPL DREKAESYTL TVVAKDKGVP
SLSTSKSIKV HVSDENDNAP RFMQSVYDVY VTENNVPGAY IYAVSAVDPD VGQNAYVTYS
ILECEIQGMS ILTYVSINSE NGYLYALRSF DYEQIKEFSF MVHAKDSGAP ELTANATVNV
IIVDQNDNAP SVIAPLGKNG TAREHLPRSA EPGYLVTRIV ATDADDGENA RLSYSILRGN
ELGMFRMDWR TGELRTARRV SSKRDPPHPY DLLIEVRDHG QPPLSSSASI NVLLVDSVVE
GRSGDRGSVK SKEGSLDLTL ILIIALGSVS FIFLLAMIVL AVRCQKDKKL NIYTCMAGDS
CCQCCSRQAR GRKKKLSKSD IMLVQSTNVA STAQVPVEES GSFGSHHQNQ NYCYQVCLTP
ESAKTDLMFL KPCSPSRSTD TEHNPCGAIV TGYADQQPDI ISNGSILSSE TKHQRTELSY
LVDRPRRVNS SAFQEADIVS SKDSGHGDSE QGDSDHDATN RGHTAGADLF SNCTEECKAL
GHSDRCWMPS FMPGDSRQGA DYRSNLHVPG MDAVPDTEVQ ESVVPGDACN RADDRSFSTF
GKDKSHHGTL TRHELHTLLP SARAPYKPNY LCEYSLKMYD F
//
