ID TTC41_RAT Reviewed; 1309 AA.
AC Q6P3V7;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Tetratricopeptide repeat protein 41 {ECO:0000250|UniProtKB:Q692V3};
DE Short=TPR repeat protein 41 {ECO:0000250|UniProtKB:Q692V3};
DE AltName: Full=Grp94-neighboring nucleotidase {ECO:0000250|UniProtKB:Q692V3};
GN Name=Ttc41 {ECO:0000250|UniProtKB:Q692V3};
GN Synonyms=Gnn {ECO:0000250|UniProtKB:Q692V3};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P3V7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P3V7-2; Sequence=VSP_034502, VSP_034503;
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DR EMBL; AABR03057641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03059265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03060536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03060891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03061268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03061651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC063813; AAH63813.1; -; mRNA.
DR AlphaFoldDB; Q6P3V7; -.
DR STRING; 10116.ENSRNOP00000036382; -.
DR PhosphoSitePlus; Q6P3V7; -.
DR PaxDb; 10116-ENSRNOP00000036382; -.
DR UCSC; RGD:1302940; rat. [Q6P3V7-1]
DR AGR; RGD:1302940; -.
DR RGD; 1302940; Ttc41.
DR eggNOG; ENOG502QUVD; Eukaryota.
DR InParanoid; Q6P3V7; -.
DR PRO; PR:Q6P3V7; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR19860; DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED; 1.
DR PANTHER; PTHR19860:SF18; FIRST GENE UPSTREAM OF NT5DC3; 1.
DR Pfam; PF05729; NACHT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1309
FT /note="Tetratricopeptide repeat protein 41"
FT /id="PRO_0000342551"
FT REPEAT 399..432
FT /note="TPR 1"
FT REPEAT 651..684
FT /note="TPR 2"
FT REPEAT 817..851
FT /note="TPR 3"
FT REPEAT 859..892
FT /note="TPR 4"
FT REPEAT 989..1024
FT /note="TPR 5"
FT REPEAT 1042..1079
FT /note="TPR 6"
FT VAR_SEQ 399
FT /note="P -> T (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034502"
FT VAR_SEQ 400..1309
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034503"
FT CONFLICT 32
FT /note="I -> M (in Ref. 2; AAH63813)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1309 AA; 150287 MW; EAEDA8C7022E6CFA CRC64;
MIEEAIETAQ RYNSQPILKR QKPIRPYICS TIDFQDERDF LAKTIFPQLN DFCSSRGTYF
KAVDLRWSAL KAHKSFTNNQ FRQYSCLHSQ HLKLCLDYVN RCFPFFICLL GQTYGDFLPD
YTPFLLSKVK DLESLSKGEQ NLYVAAKNGY PWVLKTPNCS LTEFEIIQAA FRKKSQFQFF
YFRTSNSLLR TFSEEEEEEE EKLSSGYQVD RQGKVKVGKL KAKIIGKGLP VRFYRDLDEL
GDMVLKDWSA VVEELYPVTM IMENIDYKHS FENLYHEEFV ENCKQVFVIS KESNRTFEML
ERFAIKDLEL NSDSTVAGAG LDSILRINSL PTCKSILLLC GERGCGKSTL IANWVDDFKS
RHPGVLMVPY FVGSTCESCD IMSVMHYFIM ELQHRANGPQ LEMDFLNEDS NVLVFSLLIE
VFMAAISLKP CILVLDGIEE LVGIYGISGQ KAKDFSWLPR SLPPHCKFIL SSVSSSLSCK
SLCARPDVKT VELNSLGDED TKFSIFRQHL SAPDQERFGQ SKPILRKKPN LNPLKLTLIA
SELQECRIYR NEFQCLREYL EVASVQELWE LILKRWVEDY SWPLKHKETT VDNVISGACG
WVVDVLCLLC ISHCGLAEDE LLQILDMMGY RDHHKVTAVH WAAFRNATKN WIQEKPNGLL
YFQHQSLRNA VEHKMLGVTI SVRESNPNVS QNSTNHKKVH FHQVLMKYFQ RQTIFWRVYQ
ELPWHMKMSG YWEGLCGFIT SPIITDFISK IQNPSLWTRL HLVHYWDVLL EAGSDVLEAF
LLSAAKIEAE DSQKLKKRTT LSGMTVCPEA LQATKFLTFL LFLWGFLTLL GNRRANNLFS
GAAPFLVSVQ SPSMTEMLLK AQNAIGELYL DIGMMQKGLT YFQKAWSNLL RFTLSDLKIS
QELMKQKVKV MNNLAKSASE EFLKENHVLE YATEVSKYVM DNPRDQATMR YTEGVLIPVG
RVFALQGHSY SLLPILRRAL GDRLSNKCMS YFSSAVLMEF LFSRSQRKQA IEYYKQVIKI
KEKADSVATC KLVRKQLNIS LSDTLCKLAG QLLSGDFCHH ATMEAVSYLY RSLDLRAAHL
GPSHASIEGI LHLLREIQRS RGRRSWPQGM NQLYPEGSSC GFSLWENLPK LNFHSAQSSD
TVNTAMCMNI HRFQRAKSTE PSLVSDKAKY FPGRGKKTLT PILSMSAEEK AQNSQIRNSL
RKQPPRKKGV YPLKTYSLID KNGSVRLSRQ RVFSAELGSG RSLINSIYRQ PLRAPLSADN
PWKSISELVS EKWLFHTPHY CFTPQKSVFP RRSQIETKML KTSHDFDKE
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