ID Q6P4Y4_XENTR Unreviewed; 221 AA.
AC Q6P4Y4; F6QBM8; F6XC18;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=Apoptosis regulator BAX {ECO:0000313|RefSeq:NP_989185.1};
DE SubName: Full=BCL2-associated X protein {ECO:0000313|EMBL:AAH63201.1};
GN Name=bax {ECO:0000313|EMBL:AAH63201.1, ECO:0000313|RefSeq:NP_989185.1,
GN ECO:0000313|Xenbase:XB-GENE-486067};
GN Synonyms=bax-A {ECO:0000313|RefSeq:NP_989185.1}, xBax
GN {ECO:0000313|RefSeq:NP_989185.1}, xlbax
GN {ECO:0000313|RefSeq:NP_989185.1};
GN ORFNames=TGas091l04.1-001 {ECO:0000313|EMBL:CAJ81524.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH63201.1};
RN [1] {ECO:0000313|RefSeq:NP_989185.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH63201.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH63201.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAJ81524.1}
RP NUCLEOTIDE SEQUENCE.
RA Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA Zorn A.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_989185.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
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DR EMBL; BC063201; AAH63201.1; -; mRNA.
DR EMBL; CR855728; CAJ81524.1; -; mRNA.
DR RefSeq; NP_989185.1; NM_203854.1.
DR STRING; 8364.ENSXETP00000009494; -.
DR PaxDb; 8364-ENSXETP00000050759; -.
DR DNASU; 394793; -.
DR GeneID; 394793; -.
DR KEGG; xtr:394793; -.
DR AGR; Xenbase:XB-GENE-486067; -.
DR CTD; 581; -.
DR Xenbase; XB-GENE-486067; bax.
DR eggNOG; KOG4728; Eukaryota.
DR HOGENOM; CLU_085401_2_2_1; -.
DR OMA; WEGIRSH; -.
DR OrthoDB; 5385020at2759; -.
DR TreeFam; TF315834; -.
DR Proteomes; UP000008143; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd06845; Bcl-2_like; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR PANTHER; PTHR11256:SF56; BCL-2 BCL-2 HOMOLOGY REGION 1-3 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR PRINTS; PR01862; BCL2FAMILY.
DR SMART; SM00337; BCL; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 2: Evidence at transcript level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 200..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..188
FT /note="Bcl-2 Bcl-2 homology region 1-3"
FT /evidence="ECO:0000259|SMART:SM00337"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 221 AA; 24163 MW; 87E367DB1614CEEB CRC64;
MATHGAGGDY PGEDKEKNQG EGGAAGGPSL GAAGDRSGTG VSTEQILETG ELLLNGFISD
RLQNNPDVAG ARALFPGSTQ HSDPSIKRLS ECLRKIGDEL DANIELQRRI ECVPCNSPKQ
VFFHVAKELF ADGVFNWGRV VALFYFACKL VVKALCTKVP EMIRTIINWT MEYLREYVVQ
WIRDQGGWEG MLSYFGTPTW QTVGVFLAGV LTATIAIWKM S
//
