UniProt: Q6P8E5

Database: UniProt
Entry: Q6P8E5_XENTR

LinkDB:  Q6P8E5_XENTR 
Original site:  Q6P8E5_XENTR

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Ontology (3)   
   GO (3)   
Gene (6)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
   XENBASE (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   EMBL (3)   
Protein domain (5)   
   InterPro (2)   
   Pfam (1)   
   PROSITE (2)   
Literature (2)   
   PubMed (2)   
All databases (20)   

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ID   Q6P8E5_XENTR            Unreviewed;       306 AA.
AC   Q6P8E5; F7A9M2;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 122.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit beta {ECO:0000256|RuleBase:RU362099};
GN   Name=atp1b2 {ECO:0000313|EMBL:AAH61283.1,
GN   ECO:0000313|Ensembl:ENSXETP00000053762,
GN   ECO:0000313|RefSeq:NP_989070.1, ECO:0000313|Xenbase:XB-GENE-1007085};
GN   ORFNames=TNeu130b24.1-001 {ECO:0000313|EMBL:CAJ82658.1},
GN   XENTR_v90028535mg {ECO:0000313|EMBL:OCA16267.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH61283.1};
RN   [1] {ECO:0000313|RefSeq:NP_989070.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAH61283.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH61283.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CAJ82658.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA   Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA   McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA   Zorn A.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:OCA16267.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Nigerian {ECO:0000313|EMBL:OCA16267.1};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Ottilar R., Schmutz J., Salamov A., Cheng J.F., Lucas S., Pitluck S.,
RA   Gundlach H., Guo Y., Haberer G., Nasrallah J., Mayer K.F.X.,
RA   van de Peer Y., Weigel D., Grigoriev I.V.;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:OCA16267.1, ECO:0000313|Ensembl:ENSXETP00000053762}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|EMBL:OCA16267.1,
RC   ECO:0000313|Ensembl:ENSXETP00000053762};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [6] {ECO:0000313|Ensembl:ENSXETP00000053762}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [7] {ECO:0000313|EMBL:OCA16267.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Nigerian {ECO:0000313|EMBL:OCA16267.1};
RA   Sessions A., Jenkins J., Mitros T., Lyons J.T., Dichmann D.S., Robert J.,
RA   Harland R.M., Rokhsar D.S.;
RT   "WGS assembly of Xenopus tropicalis.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|RefSeq:NP_989070.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC       which catalyzes the hydrolysis of ATP coupled with the exchange of
CC       Na(+) and K(+) ions across the plasma membrane.
CC       {ECO:0000256|RuleBase:RU362099}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC       pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC       {ECO:0000256|ARBA:ARBA00005876, ECO:0000256|RuleBase:RU362099}.
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DR   EMBL; BC061283; AAH61283.1; -; mRNA.
DR   EMBL; CR760087; CAJ82658.1; -; mRNA.
DR   EMBL; KV460638; OCA16267.1; -; Genomic_DNA.
DR   RefSeq; NP_989070.1; NM_203739.1.
DR   STRING; 8364.ENSXETP00000041827; -.
DR   PaxDb; 8364-ENSXETP00000062919; -.
DR   DNASU; 394667; -.
DR   Ensembl; ENSXETT00000053762; ENSXETP00000053762; ENSXETG00000025056.
DR   GeneID; 394667; -.
DR   KEGG; xtr:394667; -.
DR   AGR; Xenbase:XB-GENE-1007085; -.
DR   AGR; Xenbase:XB-GENE-5892549; -.
DR   CTD; 482; -.
DR   Xenbase; XB-GENE-1007085; atp1b2.
DR   HOGENOM; CLU_057702_1_1_1; -.
DR   OMA; NIECRIN; -.
DR   OrthoDB; 2880589at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Bgee; ENSXETG00000025056; Expressed in gastrula and 9 other cell types or tissues.
DR   GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 2.60.40.1660; Na, k-atpase alpha subunit; 1.
DR   InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR   InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR   NCBIfam; TIGR01107; Na_K_ATPase_bet; 1.
DR   PANTHER; PTHR11523; SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT; 1.
DR   PANTHER; PTHR11523:SF26; SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2; 1.
DR   Pfam; PF00287; Na_K-ATPase; 1.
DR   PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR   PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Ion transport {ECO:0000256|RuleBase:RU362099};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362099};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362099};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362099}; Transport {ECO:0000256|RuleBase:RU362099}.
FT   TRANSMEM        37..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362099"
SQ   SEQUENCE   306 AA;  34439 MW;  6BB93A2C5D6182FA CRC64;
     MAAMSQKRSC GEIMNEFKEF MWNPRTREFM GRTASSWGLI VSFYLVFYAF LTGMFALSMY
     VMLQTIDEYT PKYWDRLTSP GLMIRPKTDT LEIVYSISGN SSWAPYVSQL NSMLDPYNDT
     VQMQQGSVCP SGVFNKQDDT GDVRNYPKKA CQFLRSSLGD CSGLTDPTYG YSTGSPCLLI
     KMNKIINFYP GVIPSLSNTS ITINCTGTTA NMDQMLGSRT YYPSSNPSNG TSNGTSLGTM
     DLMYFPYYGN RAQKNYSQPL VAVKFYNLTL NQDLYVQCRA NAVNINTNDS QDKFSGRVSF
     KLHINK
//

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