ID Q6PAP2_MOUSE Unreviewed; 647 AA.
AC Q6PAP2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 150.
DE SubName: Full=Tie1 protein {ECO:0000313|EMBL:AAH60182.1};
DE SubName: Full=Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 {ECO:0000313|Ensembl:ENSMUSP00000139279.2};
GN Name=Tie1 {ECO:0000313|EMBL:AAH60182.1,
GN ECO:0000313|Ensembl:ENSMUSP00000139279.2, ECO:0000313|MGI:MGI:99906};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH60182.1};
RN [1] {ECO:0000313|EMBL:AAH60182.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH60182.1};
RC TISSUE=Brain {ECO:0000313|EMBL:AAH60182.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000139279.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000139279.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000139279.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000139279.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; BC057004; AAH57004.1; -; mRNA.
DR EMBL; BC060182; AAH60182.1; -; mRNA.
DR ProteomicsDB; 337196; -.
DR Antibodypedia; 32289; 776 antibodies from 39 providers.
DR Ensembl; ENSMUST00000184261.8; ENSMUSP00000139279.2; ENSMUSG00000033191.15.
DR AGR; MGI:99906; -.
DR MGI; MGI:99906; Tie1.
DR VEuPathDB; HostDB:ENSMUSG00000033191; -.
DR GeneTree; ENSGT00940000157693; -.
DR HOGENOM; CLU_423323_0_0_1; -.
DR ChiTaRS; Tie1; mouse.
DR Proteomes; UP000000589; Chromosome 4.
DR Bgee; ENSMUSG00000033191; Expressed in cardiac muscle of left ventricle and 198 other cell types or tissues.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR26391; INACTIVE TYROSINE-PROTEIN KINASE 7; 1.
DR PANTHER; PTHR26391:SF18; PROTEIN KINASE RECEPTOR TIE-1, PUTATIVE-RELATED; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6PAP2,
KW ECO:0007829|ProteomicsDB:Q6PAP2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..647
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015098424"
FT DOMAIN 223..254
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 309..343
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 349..440
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 444..543
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 546..638
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DISULFID 244..253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 333..342
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 647 AA; 69980 MW; A713C038D1D19EEB CRC64;
MVWWGSSLLL PTLFLASHVG ASVDLTLLAN LRITDPQRFF LTCVSGEAGA GRSSDPPLLL
EKDDRIVRTF PPGQPLYLAR NGSHQVTLRG FSKPSDLVGV FSCVGGAGAR RTRVLYVHNS
PGAHLFPDKV THTVNKGDTA VLSAHVHKEK QTDVIWKNNG SYFNTLDWQE ADDGRFQLQL
QNVQPPSSGI YSATYLEASP LGSAFFRLIV RGCGAGRWGP GCVKDCPGCL HGGVCHDHDG
ECVCPPGFTG TRCEQACREG RFGQSCQEQC PGTAGCRGLT FCLPDPYGCS CGSGWRGSQC
QEACAPGHFG ADCRLQCQCQ NGGTCDRFSG CVCPSGWHGV HCEKSDRIPQ ILSMATEVEF
NIGTMPRINC AAAGNPFPVR GSMKLRKPDG TMLLSTKVIV EPDRTTAEFE VPSLTLGDSG
FWECRVSTSG GQDSRRFKVN VKVPPVPLTA PRLLAKQSRQ LVVSPLVSFS GDGPISSVRL
HYRPQDSTIA WSAIVVDPSE NVTLMNLKPK TGYNVRVQLS RPGEGGEGGW GPSALMTTDC
PEPLLQPWLE SWHVEGPDRL RVSWSLPSVP LSGDGFLLRL WDGARGQERR ENISFPQART
ALLTGLTPGT HYQLDVRLYH CTLLGPASPP AHVHLPPSGR PTLGRMG
//
