ID Q6PC07_DANRE Unreviewed; 196 AA.
AC Q6PC07; A0A0B5JQ47;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 145.
DE SubName: Full=Purpurin {ECO:0000313|EMBL:BAF62293.1, ECO:0000313|RefSeq:NP_956259.1};
DE SubName: Full=Rbp4l {ECO:0000313|EMBL:AJG06000.1};
DE SubName: Full=Retinol-binding protein 4,-like {ECO:0000313|EMBL:AAH59516.1, ECO:0000313|Ensembl:ENSDARP00000065658};
DE Flags: Fragment;
GN Name=rbp4l {ECO:0000313|EMBL:AAH59516.1,
GN ECO:0000313|Ensembl:ENSDARP00000065658,
GN ECO:0000313|RefSeq:NP_956259.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-7591};
GN Synonyms=purpurin {ECO:0000313|EMBL:BAF62293.1}, zgc:73163
GN {ECO:0000313|RefSeq:NP_956259.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AJG06000.1};
RN [1] {ECO:0000313|EMBL:AAH59516.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Wild-type {ECO:0000313|EMBL:AAH59516.1};
RC TISSUE=Eye {ECO:0000313|EMBL:AAH59516.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_956259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_956259.1};
RX PubMed=16379021;
RA Vihtelic T.S., Fadool J.M., Gao J., Thornton K.A., Hyde D.R., Wistow G.;
RT "Expressed sequence tag analysis of zebrafish eye tissues for NEIBank.";
RL Mol. Vis. 11:1083-1100(2005).
RN [3] {ECO:0000313|EMBL:BAF62293.1, ECO:0000313|RefSeq:NP_956259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_956259.1};
RX PubMed=17466280; DOI=10.1016/j.brainres.2007.03.075;
RA Tanaka M., Murayama D., Nagashima M., Higashi T., Mawatari K.,
RA Matsukawa T., Kato S.;
RT "Purpurin expression in the zebrafish retina during early development and
RT after optic nerve lesion in adults.";
RL Brain Res. 1153:34-42(2007).
RN [4] {ECO:0000313|RefSeq:NP_956259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_956259.1};
RX PubMed=19748496;
RA Nagashima M., Mawatari K., Tanaka M., Higashi T., Saito H., Muramoto K.,
RA Matsukawa T., Koriyama Y., Sugitani K., Kato S.;
RT "Purpurin is a key molecule for cell differentiation during the early
RT development of zebrafish retina.";
RL Brain Res. 1302:54-63(2009).
RN [5] {ECO:0000313|RefSeq:NP_956259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_956259.1};
RX PubMed=20238054;
RA Nagashima M., Saito J., Mawatari K., Mori Y., Matsukawa T., Koriyama Y.,
RA Kato S.;
RT "A hypoplastic retinal lamination in the purpurin knock down embryo in
RT zebrafish.";
RL Adv. Exp. Med. Biol. 664:517-524(2010).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000065658}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000065658};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [7] {ECO:0000313|RefSeq:NP_956259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_956259.1};
RX PubMed=23412571; DOI=10.1074/mcp.m111.015594;
RA Konzer A., Ruhs A., Braun H., Jungblut B., Braun T., Kruger M.;
RT "Stable isotope labeling in zebrafish allows in vivo monitoring of cardiac
RT morphogenesis.";
RL Mol. Cell. Proteomics 12:1502-1512(2013).
RN [8] {ECO:0000313|Ensembl:ENSDARP00000065658, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000065658};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [9] {ECO:0000313|EMBL:AJG06000.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26190107; DOI=10.1016/j.celrep.2015.06.047;
RA Gao X., Metzger U., Panza P., Mahalwar P., Alsheimer S., Geiger H.,
RA Maischein H.M., Levesque M.P., Templin M., Sollner C.;
RT "A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies
RT Draxin as a Secreted Netrin-1 Antagonist.";
RL Cell Rep. 12:694-708(2015).
RN [10] {ECO:0000313|RefSeq:NP_956259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_956259.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [11] {ECO:0000313|RefSeq:NP_956259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_956259.1};
RX PubMed=25692557;
RA Takamiya M., Weger B.D., Schindler S., Beil T., Yang L., Armant O.,
RA Ferg M., Schlunck G., Reinhard T., Dickmeis T., Rastegar S., Strahle U.;
RT "Molecular description of eye defects in the zebrafish Pax6b mutant,
RT sunrise, reveals a Pax6b-dependent genetic network in the developing
RT anterior chamber.";
RL PLoS ONE 10:e0117645-e0117645(2015).
RN [12] {ECO:0000313|RefSeq:NP_956259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_956259.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [13] {ECO:0000313|Ensembl:ENSDARP00000144298}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000144298};
RG Ensembl;
RL Submitted (OCT-2017) to UniProtKB.
RN [14] {ECO:0000313|RefSeq:NP_956259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_956259.1};
RX PubMed=29272338;
RA Lee S.L.J., Horsfield J.A., Black M.A., Rutherford K., Gemmell N.J.;
RT "Identification of sex differences in zebrafish (Danio rerio) brains during
RT early sexual differentiation and masculinization using 17alpha-
RT methyltestoterone.";
RL Biol. Reprod. 99:446-460(2018).
RN [15] {ECO:0000313|RefSeq:NP_956259.1}
RP IDENTIFICATION.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_956259.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000256|ARBA:ARBA00006889}.
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DR EMBL; AL844141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC059516; AAH59516.1; -; mRNA.
DR EMBL; BC152210; AAI52211.1; -; mRNA.
DR EMBL; KM655654; AJG06000.1; -; mRNA.
DR EMBL; AB242211; BAF62293.1; -; Genomic_DNA.
DR RefSeq; NP_956259.1; NM_199965.1.
DR STRING; 7955.ENSDARP00000065658; -.
DR PaxDb; 7955-ENSDARP00000065658; -.
DR Ensembl; ENSDART00000065659.5; ENSDARP00000065658.4; ENSDARG00000044684.6.
DR Ensembl; ENSDART00000176689.2; ENSDARP00000144298.1; ENSDARG00000044684.6.
DR GeneID; 335651; -.
DR KEGG; dre:335651; -.
DR AGR; ZFIN:ZDB-GENE-030131-7591; -.
DR CTD; 335651; -.
DR ZFIN; ZDB-GENE-030131-7591; rbp4l.
DR eggNOG; ENOG502QQ8B; Eukaryota.
DR HOGENOM; CLU_094618_0_0_1; -.
DR OMA; HCLAQSC; -.
DR OrthoDB; 5342507at2759; -.
DR TreeFam; TF331445; -.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000044684; Expressed in larva and 11 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR GO; GO:0034632; F:retinol transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR CDD; cd00743; lipocalin_RBP_like; 1.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR022271; Lipocalin_ApoD.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002449; Retinol-bd/Purpurin.
DR PANTHER; PTHR11873:SF1; PURPURIN; 1.
DR PANTHER; PTHR11873; RETINOL-BINDING PROTEIN 4; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PIRSF; PIRSF036893; Lipocalin_ApoD; 1.
DR PIRSF; PIRSF500204; RBP_purpurin; 1.
DR PRINTS; PR00179; LIPOCALIN.
DR PRINTS; PR01174; RETINOLBNDNG.
DR SUPFAM; SSF50814; Lipocalins; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR036893-50};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6PC07};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Retinol-binding {ECO:0000256|ARBA:ARBA00023072};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_956259.1}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..196
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_956259.1"
FT /id="PRO_5035035813"
FT DOMAIN 41..176
FT /note="Lipocalin/cytosolic fatty-acid binding"
FT /evidence="ECO:0000259|Pfam:PF00061"
FT DISULFID 24..182
FT /evidence="ECO:0000256|PIRSR:PIRSR036893-50"
FT DISULFID 90..196
FT /evidence="ECO:0000256|PIRSR:PIRSR036893-50"
FT DISULFID 142..151
FT /evidence="ECO:0000256|PIRSR:PIRSR036893-50"
FT NON_TER 196
FT /evidence="ECO:0000313|EMBL:AJG06000.1"
SQ SEQUENCE 196 AA; 21968 MW; 89D5C68B47FA46D9 CRC64;
MGFYKFALLV VFLSYIERCF SASCAVESFT VKDDFDPKRY AGKWYAQQKK DPEGLFLQDN
ISAEYTIDDD GTMTASSKGR VTLFGFWVVC ADMAAQYSVP DPTTPAKMFM NYQGLASYLS
SGGDNYWVID TDYDNYAITY ACRTLKDDGS CDDGYSLVFS RNPRGLPPAI QRLVRQKQDE
ICMAGQFQPV LQSGAC
//
