ID Q6PC63_DANRE Unreviewed; 218 AA.
AC Q6PC63; Q2M5E8; Q5TZ23;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 141.
DE RecName: Full=Protein lin-7 homolog {ECO:0000256|PIRNR:PIRNR038039};
GN Name=lin7a {ECO:0000313|EMBL:AAH59460.1,
GN ECO:0000313|Ensembl:ENSDARP00000022617,
GN ECO:0000313|RefSeq:NP_957003.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1665};
GN Synonyms=lin7b {ECO:0000313|EMBL:AAT85672.1,
GN ECO:0000313|RefSeq:NP_957003.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAT85672.1};
RN [1] {ECO:0000313|EMBL:AAH59460.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Wild-type {ECO:0000313|EMBL:AAH59460.1};
RC TISSUE=Eye {ECO:0000313|EMBL:AAH59460.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAT85672.1, ECO:0000313|RefSeq:NP_957003.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957003.1};
RX PubMed=16109407; DOI=10.1016/j.exer.2005.05.009;
RA Wei X., Luo Y., Hyde D.R.;
RT "Molecular cloning of three zebrafish lin7 genes and their expression
RT patterns in the retina.";
RL Exp. Eye Res. 82:122-131(2006).
RN [3] {ECO:0000313|RefSeq:NP_957003.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957003.1};
RX PubMed=17436278;
RA Catalano A.E., Raymond P.A., Goldman D., Wei X.;
RT "Zebrafish dou yan mutation causes patterning defects and extensive cell
RT death in the retina.";
RL Dev. Dyn. 236:1295-1306(2007).
RN [4] {ECO:0000313|RefSeq:NP_957003.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957003.1};
RX PubMed=19759292;
RA Yang X., Zou J., Hyde D.R., Davidson L.A., Wei X.;
RT "Stepwise maturation of apicobasal polarity of the neuroepithelium is
RT essential for vertebrate neurulation.";
RL J. Neurosci. 29:11426-11440(2009).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000022617}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000022617};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [6] {ECO:0000313|Ensembl:ENSDARP00000022617, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000022617};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|RefSeq:NP_957003.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957003.1};
RX PubMed=24875912;
RA Huang L., Zuo Z., Zhang Y., Wu M., Lin J.J., Wang C.;
RT "Use of toxicogenomics to predict the potential toxic effect of
RT Benzo(a)pyrene on zebrafish embryos: ocular developmental toxicity.";
RL Chemosphere 108:55-61(2014).
RN [8] {ECO:0000313|RefSeq:NP_957003.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957003.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [9] {ECO:0000313|RefSeq:NP_957003.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957003.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [10] {ECO:0000313|RefSeq:NP_957003.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957003.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [11] {ECO:0000313|RefSeq:NP_957003.1}
RP IDENTIFICATION.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957003.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in establishing and maintaining the asymmetric
CC distribution of channels and receptors at the plasma membrane of
CC polarized cells. {ECO:0000256|PIRNR:PIRNR038039}.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cell membrane {ECO:0000256|ARBA:ARBA00004202,
CC ECO:0000256|PIRNR:PIRNR038039}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the lin-7 family.
CC {ECO:0000256|ARBA:ARBA00008546, ECO:0000256|PIRNR:PIRNR038039}.
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DR EMBL; BX537156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX537308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC059460; AAH59460.1; -; mRNA.
DR EMBL; AY584747; AAT85672.1; -; mRNA.
DR RefSeq; NP_957003.1; NM_200709.1.
DR STRING; 7955.ENSDARP00000022617; -.
DR PaxDb; 7955-ENSDARP00000022617; -.
DR Ensembl; ENSDART00000019748.9; ENSDARP00000022617.8; ENSDARG00000013414.9.
DR GeneID; 393682; -.
DR KEGG; dre:393682; -.
DR AGR; ZFIN:ZDB-GENE-040426-1665; -.
DR CTD; 8825; -.
DR ZFIN; ZDB-GENE-040426-1665; lin7a.
DR eggNOG; KOG3550; Eukaryota.
DR HOGENOM; CLU_097962_0_0_1; -.
DR OMA; EHETEFI; -.
DR OrthoDB; 4175920at2759; -.
DR TreeFam; TF316850; -.
DR Reactome; R-DRE-212676; Dopamine Neurotransmitter Release Cycle.
DR Proteomes; UP000000437; Chromosome 4.
DR Bgee; ENSDARG00000013414; Expressed in brain and 24 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-UniRule.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0097025; C:MPP7-DLG1-LIN7 complex; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-UniRule.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0097016; F:L27 domain binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-UniRule.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR GO; GO:1903361; P:protein localization to basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR017365; LIN7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14063; PROTEIN LIN-7 HOMOLOG; 1.
DR PANTHER; PTHR14063:SF4; PROTEIN LIN-7 HOMOLOG A; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038039; Lin-7_homologue; 2.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 2: Evidence at transcript level;
KW Cell junction {ECO:0000256|PIRNR:PIRNR038039};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR038039};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|PIRNR:PIRNR038039};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038039};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR038039};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR038039}.
FT DOMAIN 11..66
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 94..176
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT COILED 179..215
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 218 AA; 24334 MW; FAE5CEA171E485FB CRC64;
MATVTVQPLT LERDVTRAIE LLEKLQESGD VPGHKLQSLK KVLQSEFCTA IREVYQYMHE
TITVNGCPEY QARATAKATV AAFAASEGHS HPRVVELPKT DEGLGFNVMG GKEQNSPIYI
SRIIPGGVAE RHGGLKRGDQ LLSVNGVSVE GEHHEKAVEL LKAAKDSVKL VVRYTPKVLE
EMEARFEKLR TARRRQQQQI LMQQQQQQNL AAQQNHMS
//
