GenomeNet

Database: UniProt
Entry: Q6PFE3
LinkDB: Q6PFE3
Original site: Q6PFE3 
ID   RA54B_MOUSE             Reviewed;         886 AA.
AC   Q6PFE3; A2AIV0;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   16-OCT-2019, entry version 126.
DE   RecName: Full=DNA repair and recombination protein RAD54B;
DE            EC=3.6.4.-;
DE   AltName: Full=RAD54 homolog B;
GN   Name=Rad54b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryonic brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION.
RX   PubMed=12548566; DOI=10.1002/immu.200310009;
RA   Bross L., Wesoly J., Buerstedde J.-M., Kanaar R., Jacobs H.;
RT   "Somatic hypermutation does not require Rad54 and Rad54B-mediated
RT   homologous recombination.";
RL   Eur. J. Immunol. 33:352-357(2003).
CC   -!- FUNCTION: Involved in DNA repair and mitotic recombination. May
CC       play an active role in recombination processes in concert with
CC       other members of the RAD52 epistasis group.
CC       {ECO:0000269|PubMed:12548566}.
CC   -!- SUBUNIT: Interacts with RAD51 through the NH2-terminal domain.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC       {ECO:0000305}.
DR   EMBL; AL732538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC057604; AAH57604.1; -; mRNA.
DR   CCDS; CCDS17970.1; -.
DR   RefSeq; NP_001034645.1; NM_001039556.3.
DR   SMR; Q6PFE3; -.
DR   STRING; 10090.ENSMUSP00000066977; -.
DR   iPTMnet; Q6PFE3; -.
DR   PhosphoSitePlus; Q6PFE3; -.
DR   EPD; Q6PFE3; -.
DR   MaxQB; Q6PFE3; -.
DR   PaxDb; Q6PFE3; -.
DR   PRIDE; Q6PFE3; -.
DR   Ensembl; ENSMUST00000070755; ENSMUSP00000066977; ENSMUSG00000078773.
DR   GeneID; 623474; -.
DR   KEGG; mmu:623474; -.
DR   UCSC; uc008rzs.2; mouse.
DR   CTD; 25788; -.
DR   MGI; MGI:3605986; Rad54b.
DR   eggNOG; KOG0390; Eukaryota.
DR   eggNOG; COG0553; LUCA.
DR   GeneTree; ENSGT00940000156966; -.
DR   HOGENOM; HOG000204521; -.
DR   InParanoid; Q6PFE3; -.
DR   KO; K10877; -.
DR   OMA; MADFCNP; -.
DR   OrthoDB; 93727at2759; -.
DR   PhylomeDB; Q6PFE3; -.
DR   TreeFam; TF101223; -.
DR   ChiTaRS; Rad54b; mouse.
DR   PRO; PR:Q6PFE3; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000078773; Expressed in 143 organ(s), highest expression level in dorsal pancreas.
DR   ExpressionAtlas; Q6PFE3; baseline and differential.
DR   Genevisible; Q6PFE3; MM.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015616; F:DNA translocase activity; ISO:MGI.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:MGI.
DR   GO; GO:0008340; P:determination of adult lifespan; IGI:MGI.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:MGI.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR   GO; GO:0042493; P:response to drug; IMP:MGI.
DR   GO; GO:0010212; P:response to ionizing radiation; IMP:MGI.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN         1    886       DNA repair and recombination protein
FT                                RAD54B.
FT                                /FTId=PRO_0000074341.
FT   DOMAIN      291    458       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      627    788       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     304    311       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       409    412       DEGH box.
FT   MOD_RES      14     14       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9Y620}.
SQ   SEQUENCE   886 AA;  99338 MW;  A723501E5D5723A6 CRC64;
     MRRSAAPSQV QGKSFKKTRF IPPGRSNADV SKEITKMSPD PKLFQGAEQS QNDPGVCSSN
     PCPSEGIPRE VGDGTRVDPL PPVHSASKEI TESKAQEEEA SSLLKYFSVV WCKASKKKHK
     KWEGDAILIV RGRSFTLKDL EGKDIGRGIG YKFKDLENVE EGQTLIIGGK EIEILGTISS
     DDFNSGKCFQ HGSGSPAVPS SQAARKCFSN PFKSVCQSTQ AQGKRWNDCR PRHNPCTPNA
     LVMPRPDENH QRMFNRHCSP IVDVVIDPHL VHHLRPHQKD GIIFLYECVM GMRAVGKCGA
     ILADEMGLGK TLQCISLIWT LQCQGPYGGK PVIKKTLIVT PGSLVNNWRK EFQKWLGSER
     IKIFTVDQDH KVEEFINSTF HSVLIISYEM LLRSLDQIKT IPFGLLICDE GHRLKNSSIK
     TTTALSSLSC EKTVILTGTP VQNDLQEFFA LVDFVNPGIL GSLSSYRKIY EEPIIISREP
     SSSKEERELG ERRATELTRL TGRFILRRTQ EVINKYLPPK IENVVFCRPG ALQIELYRKL
     LRSQSVRFCL QGLLENSAHL ICIGALKKLC NHPCLLFSSV KGKEFSSSCE ENEERNLCQG
     LLSVFPAGYN PLQFSEEESG KLQVLVKLLA VIHELRPTEK VILVSNYRQT LNVLEEVCKR
     HGYACARLDG QTPVSQRQHI VDSFNSKYST DFIFLLSSKA GGVGLNLIGG SHLILYDIDW
     NPATDIQAMS RVWRDGQKHP VHIYRLLTTG TIEEKIYQRQ ISKQGLSGAV VDLTRSSEHI
     QFSVEELKNL FTLHESSHCV THDLLDCECT GEKGHTEDAS EGPVASRQCQ FGPQKSDALR
     PLSMSQLKQW KHFSGDHLNL PDPFLERIRE NVSFFFQNIT NQAPAV
//
DBGET integrated database retrieval system