ID Q6PFS3_DANRE Unreviewed; 324 AA.
AC Q6PFS3; A0A8M1PD63;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 137.
DE RecName: Full=Voltage-dependent calcium channel gamma-2 subunit {ECO:0000256|RuleBase:RU363085};
GN Name=cacng2a {ECO:0000313|Ensembl:ENSDARP00000041387,
GN ECO:0000313|RefSeq:NP_956935.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1401};
GN Synonyms=cacng2 {ECO:0000313|RefSeq:NP_956935.1}, zgc:64200
GN {ECO:0000313|RefSeq:NP_956935.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH57439.1};
RN [1] {ECO:0000313|EMBL:AAH57439.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH57439.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_956935.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22951640;
RA Kok F.O., Taibi A., Wanner S.J., Xie X., Moravec C.E., Love C.E.,
RA Prince V.E., Mumm J.S., Sirotkin H.I.;
RT "Zebrafish rest regulates developmental gene expression but not
RT neurogenesis.";
RL Development 139:3838-3848(2012).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000041387}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000041387};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000041387, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000041387};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_956935.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_956935.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [7] {ECO:0000313|RefSeq:NP_956935.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26178704; DOI=10.1002/dneu.22327;
RA Roy B., Ahmed K.T., Cunningham M.E., Ferdous J., Mukherjee R., Zheng W.,
RA Chen X.Z., Ali D.W.;
RT "Zebrafish TARP Cacng2 is required for the expression and normal
RT development of AMPA receptors at excitatory synapses.";
RL Dev. Neurobiol. 76:487-506(2016).
RN [8] {ECO:0000313|RefSeq:NP_956935.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [9] {ECO:0000313|RefSeq:NP_956935.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28392072;
RA Thomas-Jinu S., Gordon P.M., Fielding T., Taylor R., Smith B.N.,
RA Snowden V., Blanc E., Vance C., Topp S., Wong C.H., Bielen H.,
RA Williams K.L., McCann E.P., Nicholson G.A., Pan-Vazquez A., Fox A.H.,
RA Bond C.S., Talbot W.S., Blair I.P., Shaw C.E., Houart C.;
RT "Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts
RT Required for Normal Motor Development.";
RL Neuron 94:322-336(2017).
RN [10] {ECO:0000313|RefSeq:NP_956935.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Regulates the trafficking and gating properties of AMPA-
CC selective glutamate receptors (AMPARs). Promotes their targeting to the
CC cell membrane and synapses and modulates their gating properties by
CC slowing their rates of activation, deactivation and desensitization.
CC Does not show subunit-specific AMPA receptor regulation and regulates
CC all AMPAR subunits. Thought to stabilize the calcium channel in an
CC inactivated (closed) state. {ECO:0000256|RuleBase:RU363085}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363085}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363085}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000256|ARBA:ARBA00007111, ECO:0000256|RuleBase:RU363085}.
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DR EMBL; BX901883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057439; AAH57439.1; -; mRNA.
DR RefSeq; NP_956935.1; NM_200641.1.
DR STRING; 7955.ENSDARP00000041387; -.
DR TCDB; 8.A.16.2.12; the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.
DR PaxDb; 7955-ENSDARP00000041387; -.
DR Ensembl; ENSDART00000041388.7; ENSDARP00000041387.6; ENSDARG00000032565.7.
DR GeneID; 393614; -.
DR KEGG; dre:393614; -.
DR AGR; ZFIN:ZDB-GENE-040426-1401; -.
DR CTD; 393614; -.
DR ZFIN; ZDB-GENE-040426-1401; cacng2a.
DR eggNOG; ENOG502QSNI; Eukaryota.
DR HOGENOM; CLU_053704_0_1_1; -.
DR OMA; CIQKESK; -.
DR OrthoDB; 2957055at2759; -.
DR TreeFam; TF327980; -.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000032565; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0016247; F:channel regulator activity; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0098990; P:AMPA selective glutamate receptor signaling pathway; IMP:ZFIN.
DR GO; GO:0099590; P:neurotransmitter receptor internalization; IBA:GO_Central.
DR GO; GO:0098943; P:neurotransmitter receptor transport, postsynaptic endosome to lysosome; IBA:GO_Central.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IBA:GO_Central.
DR GO; GO:0019226; P:transmission of nerve impulse; IBA:GO_Central.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR005422; VDCC_g2su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT; 1.
DR PANTHER; PTHR12107:SF1; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01602; VDCCGAMMA2.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|RuleBase:RU363085};
KW Calcium channel {ECO:0000256|RuleBase:RU363085};
KW Calcium transport {ECO:0000256|RuleBase:RU363085};
KW Ion channel {ECO:0000256|RuleBase:RU363085};
KW Ion transport {ECO:0000256|RuleBase:RU363085};
KW Membrane {ECO:0000256|RuleBase:RU363085};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|RuleBase:RU363085};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363085};
KW Transport {ECO:0000256|RuleBase:RU363085};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU363085}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 106..128
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 135..158
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 178..202
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT REGION 233..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 35888 MW; 9722EE10D6059B64 CRC64;
MGVFDRGVQM LLTTVGAFAA FSLMTIAVGT DYWLYSRGVC KIKTNNENET SKKNEEVMTH
SGLWRTCCLE GNFKGLCKQI DHFPEDTDYE ADASEYFLRA VRASSIFPIL SVILLFMGGL
CIAASEFYKS RHNIILSAGI LFVSAGLSNI IGMIVYISAN AGDPSKSDSK KNSYSYGWSF
YFGALSFIMA EMVGVLAVHM FIDRHRELRA GARAADYLQG SAITRIPSYR YRYRRRSRSS
SRSTDPSHSR DASPVGLKGF GALPSTEISM YTLTRGGDTL KGGHGTPTAT YNSERDHNFL
QVHNCIQKDL KDSSNTANRR TTPV
//
