ID Q6PGZ7_DANRE Unreviewed; 492 AA.
AC Q6PGZ7; A0A0R4IR88; Q52YL6;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 172.
DE SubName: Full=Interferon regulatory factor 6 {ECO:0000313|EMBL:AAX57954.1, ECO:0000313|Ensembl:ENSDARP00000139404};
DE SubName: Full=Irf6 protein {ECO:0000313|EMBL:AAH56772.1};
GN Name=irf6 {ECO:0000313|EMBL:AAX57954.1,
GN ECO:0000313|Ensembl:ENSDARP00000139404,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1137};
GN Synonyms=zgc:63500 {ECO:0000313|RefSeq:NP_956892.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAX57954.1};
RN [1] {ECO:0000313|EMBL:AAH56772.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB {ECO:0000313|EMBL:AAH56772.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AAH56772.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAX57954.1, ECO:0000313|RefSeq:NP_956892.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|EMBL:AAX57954.1,
RC ECO:0000313|RefSeq:NP_956892.1};
RX PubMed=15939375; DOI=10.1016/j.modgep.2005.03.002;
RA Ben J., Jabs E.W., Chong S.S.;
RT "Genomic, cDNA and embryonic expression analysis of zebrafish IRF6, the
RT gene mutated in the human oral clefting disorders Van der Woude and
RT popliteal pterygium syndromes.";
RL Gene Expr. Patterns 5:629-638(2005).
RN [3] {ECO:0000313|RefSeq:NP_956892.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_956892.1};
RX PubMed=18039395;
RA Stein C., Caccamo M., Laird G., Leptin M.;
RT "Conservation and divergence of gene families encoding components of innate
RT immune response systems in zebrafish.";
RL Genome Biol. 8:R251-R251(2007).
RN [4] {ECO:0000313|RefSeq:NP_956892.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_956892.1};
RX PubMed=19013452;
RA Sabel J.L., d'Alencon C., O'Brien E.K., Van Otterloo E., Lutz K.,
RA Cuykendall T.N., Schutte B.C., Houston D.W., Cornell R.A.;
RT "Maternal Interferon Regulatory Factor 6 is required for the
RT differentiation of primary superficial epithelia in Danio and Xenopus
RT embryos.";
RL Dev. Biol. 325:249-262(2009).
RN [5] {ECO:0000313|RefSeq:NP_956892.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_956892.1};
RX PubMed=20444275;
RA Huang B., Qi Z.T., Xu Z., Nie P.;
RT "Global characterization of interferon regulatory factor (IRF) genes in
RT vertebrates: glimpse of the diversification in evolution.";
RL BMC Immunol. 11:22-22(2010).
RN [6] {ECO:0000313|RefSeq:NP_956892.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_956892.1};
RX PubMed=19896215; DOI=10.1016/j.vetimm.2009.10.020;
RA Xu Q.Q., Chang M.X., Xiao F.S., Huang B., Nie P.;
RT "The gene and virus-induced expression of IRF-5 in grass carp
RT Ctenopharyngodon idella.";
RL Vet. Immunol. Immunopathol. 134:269-278(2010).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000139404, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139404};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|Ensembl:ENSDARP00000139404}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139404};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [9] {ECO:0000313|RefSeq:NP_956892.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_956892.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [10] {ECO:0000313|RefSeq:NP_956892.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_956892.1};
RX PubMed=27577537;
RA Li S., Lu L.F., Wang Z.X., Chen D.D., Zhang Y.A.;
RT "Fish IRF6 is a positive regulator of IFN expression and involved in both
RT of the MyD88 and TBK1 pathways.";
RL Fish Shellfish Immunol. 57:262-268(2016).
RN [11] {ECO:0000313|RefSeq:NP_956892.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_956892.1};
RX PubMed=28599080;
RA Choi T.Y., Khaliq M., Tsurusaki S., Ninov N., Stainier D.Y.R., Tanaka M.,
RA Shin D.;
RT "Bone morphogenetic protein signaling governs biliary-driven liver
RT regeneration in zebrafish through tbx2b and id2a.";
RL Hepatology 66:1616-1630(2017).
RN [12] {ECO:0000313|RefSeq:NP_956892.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_956892.1};
RX PubMed=28945736;
RA Li E.B., Truong D., Hallett S.A., Mukherjee K., Schutte B.C., Liao E.C.;
RT "Rapid functional analysis of computationally complex rare human IRF6 gene
RT variants using a novel zebrafish model.";
RL PLoS Genet. 13:e1007009-e1007009(2017).
RN [13] {ECO:0000313|RefSeq:NP_956892.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_956892.1};
RX PubMed=27958775;
RA Manesia J.K., Franch M., Tabas-Madrid D., Nogales-Cadenas R., Vanwelden T.,
RA Van Den Bosch E., Xu Z., Pascual-Montano A., Khurana S., Verfaillie C.M.;
RT "Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic
RT Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function.";
RL Stem Cells Dev. 26:573-584(2017).
RN [14] {ECO:0000313|RefSeq:NP_956892.1}
RP IDENTIFICATION.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_956892.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU570769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC056772; AAH56772.1; -; mRNA.
DR EMBL; AY725802; AAU85359.1; -; mRNA.
DR EMBL; AH014791; AAX57954.1; -; Genomic_DNA.
DR EMBL; AY857643; AAX57954.1; JOINED; Genomic_DNA.
DR RefSeq; NP_956892.1; NM_200598.2.
DR STRING; 7955.ENSDARP00000139404; -.
DR PaxDb; 7955-ENSDARP00000061534; -.
DR Ensembl; ENSDART00000169809; ENSDARP00000139404; ENSDARG00000101986.
DR Ensembl; ENSDART00000169809.2; ENSDARP00000139404.1; ENSDARG00000101986.2.
DR GeneID; 393570; -.
DR KEGG; dre:393570; -.
DR AGR; ZFIN:ZDB-GENE-040426-1137; -.
DR CTD; 3664; -.
DR ZFIN; ZDB-GENE-040426-1137; irf6.
DR eggNOG; ENOG502QRNT; Eukaryota.
DR HOGENOM; CLU_031544_0_1_1; -.
DR OMA; NEAWPKE; -.
DR OrthoDB; 3740806at2759; -.
DR TreeFam; TF328512; -.
DR Proteomes; UP000000437; Chromosome 22.
DR Bgee; ENSDARG00000101986; Expressed in mature ovarian follicle and 53 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1904888; P:cranial skeletal system development; IMP:ZFIN.
DR GO; GO:0048702; P:embryonic neurocranium morphogenesis; IMP:ZFIN.
DR GO; GO:0008544; P:epidermis development; IMP:ZFIN.
DR GO; GO:0060429; P:epithelium development; IMP:ZFIN.
DR GO; GO:1905748; P:hard palate morphogenesis; IMP:ZFIN.
DR GO; GO:0002376; P:immune system process; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF9; INTERFERON REGULATORY FACTOR 6; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6PGZ7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 7..115
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 116..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..187
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 54877 MW; 98EF8FD3FE1F589B CRC64;
MSSHPRRVRL KPWLVSQVDN ATFPGLVWLD RDAKRFQIPW KHATRHTPQQ EEENTIFKAW
AVETGKYQEG VDEPDPAKWK AQLRCALNKS REFNLIYDGT KEVPMNPLKI YDVCDIPQTP
SNPGSVPTYE TDGDEDDIPD TPEPPPPYAS HGMSASPLAA VWTPPGSVSP LQPSSCAPPP
ALPPPPALPP PAATVLPAAA APPANVWPKK EPEDVEMQPP PMEIQTPTAL DNLFITPETW
ISSLPMTDLE VQFYYRGKEV CPPLTVSNPQ GCRLFYGDLG PIVNQEELFG PVSLEQVRFP
PTEHIANDKQ RVFTSRLLDV MDRGLILEVS GHDIYAVRLC QCKVYWSGPC APNPNAPNLI
ERQQKVKLFC LESFLSGVIT HQRGQSSDAP LYDIHLCFGE EWPDGRPRER KLIMVQVVPV
VARMISEMFS GDCTRSFDSG SVRLQISIPD IKDNIVTHLK QLYRLLQTHQ GPENWPLPPG
AALQLSSALH TQ
//
