ID Q6PHJ8_DANRE Unreviewed; 172 AA.
AC Q6PHJ8; A0A8M1PJZ2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 145.
DE SubName: Full=Myosin regulatory light chain 12B {ECO:0000313|RefSeq:NP_999864.1};
DE SubName: Full=Myosin, light chain 12, genome duplicate 1 {ECO:0000313|Ensembl:ENSDARP00000137464};
DE SubName: Full=Myosin, light polypeptide 9, like {ECO:0000313|EMBL:AAH56526.1};
GN Name=myl12.1 {ECO:0000313|Ensembl:ENSDARP00000137464,
GN ECO:0000313|RefSeq:NP_999864.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-4918};
GN Synonyms=bing3y {ECO:0000313|RefSeq:NP_999864.1}, hm:zeh0157
GN {ECO:0000313|RefSeq:NP_999864.1}, mlc-4
GN {ECO:0000313|RefSeq:NP_999864.1}, myl9l
GN {ECO:0000313|RefSeq:NP_999864.1}, wu:fa93e09
GN {ECO:0000313|RefSeq:NP_999864.1}, wu:fe06h06
GN {ECO:0000313|RefSeq:NP_999864.1}, zeh0157
GN {ECO:0000313|RefSeq:NP_999864.1}, zgc:65791
GN {ECO:0000313|RefSeq:NP_999864.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH56526.1};
RN [1] {ECO:0000313|RefSeq:NP_999864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RX PubMed=11116087;
RA Ton C., Hwang D.M., Dempsey A.A., Tang H.C., Yoon J., Lim M., Mably J.D.,
RA Fishman M.C., Liew C.C.;
RT "Identification, characterization, and mapping of expressed sequence tags
RT from an embryonic zebrafish heart cDNA library.";
RL Genome Res. 10:1915-1927(2000).
RN [2] {ECO:0000313|EMBL:AAH56526.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000313|EMBL:AAH56526.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_999864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RX PubMed=19439512;
RA Kassahn K.S., Dang V.T., Wilkins S.J., Perkins A.C., Ragan M.A.;
RT "Evolution of gene function and regulatory control after whole-genome
RT duplication: comparative analyses in vertebrates.";
RL Genome Res. 19:1404-1418(2009).
RN [4] {ECO:0000313|RefSeq:NP_999864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RX PubMed=23284763;
RA Mateus R., Pereira T., Sousa S., de Lima J.E., Pascoal S., Saude L.,
RA Jacinto A.;
RT "In vivo cell and tissue dynamics underlying zebrafish fin fold
RT regeneration.";
RL PLoS ONE 7:e51766-e51766(2012).
RN [5] {ECO:0000313|RefSeq:NP_999864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RX PubMed=22923438;
RA Maitre J.L., Berthoumieux H., Krens S.F., Salbreux G., Julicher F.,
RA Paluch E., Heisenberg C.P.;
RT "Adhesion functions in cell sorting by mechanically coupling the cortices
RT of adhering cells.";
RL Science 338:253-256(2012).
RN [6] {ECO:0000313|RefSeq:NP_999864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RX PubMed=23066079;
RA Behrndt M., Salbreux G., Campinho P., Hauschild R., Oswald F., Roensch J.,
RA Grill S.W., Heisenberg C.P.;
RT "Forces driving epithelial spreading in zebrafish gastrulation.";
RL Science 338:257-260(2012).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000137464, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000137464};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|Ensembl:ENSDARP00000137464}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000137464};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [9] {ECO:0000313|RefSeq:NP_999864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RX PubMed=30399336;
RA Hunter M.V., Willoughby P.M., Bruce A.E.E., Fernandez-Gonzalez R.;
RT "Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound
RT Healing.";
RL Dev. Cell 47:377-387(2018).
RN [10] {ECO:0000313|RefSeq:NP_999864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RX PubMed=30327325; DOI=10.1242/dev.167023;
RA Dingare C., Niedzwetzki A., Klemmt P.A., Godbersen S., Fuentes R.,
RA Mullins M.C., Lecaudey V.;
RT "The Hippo pathway effector Taz is required for cell morphogenesis and
RT fertilization in zebrafish. .";
RL Development 145:dev167023-dev167023(2018).
RN [11] {ECO:0000313|RefSeq:NP_999864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RX PubMed=30568597;
RA Garcia de la Serrana D., Wreggelsworth K., Johnston I.A.;
RT "Duplication of a Single myhz1.1 Gene Facilitated the Ability of Goldfish
RT (Carassius auratus) to Alter Fast Muscle Contractile Properties With
RT Seasonal Temperature Change.";
RL Front. Physiol. 9:1724-1724(2018).
RN [12] {ECO:0000313|RefSeq:NP_999864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RX PubMed=30120238;
RA Daniel K., Icha J., Horenburg C., Muller D., Norden C., Mansfeld J.;
RT "Conditional control of fluorescent protein degradation by an auxin-
RT dependent nanobody.";
RL Nat. Commun. 9:3297-3297(2018).
RN [13] {ECO:0000313|RefSeq:NP_999864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RX PubMed=31080065;
RA Shamipour S., Kardos R., Xue S.L., Hof B., Hannezo E., Heisenberg C.P.;
RT "Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes.";
RL Cell 177:1463-1479(2019).
RN [14] {ECO:0000313|RefSeq:NP_999864.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_999864.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU607104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC056526; AAH56526.1; -; mRNA.
DR RefSeq; NP_999864.1; NM_214699.2.
DR STRING; 7955.ENSDARP00000137464; -.
DR PaxDb; 7955-ENSDARP00000034885; -.
DR Ensembl; ENSDART00000166865.2; ENSDARP00000140371.1; ENSDARG00000099766.2.
DR Ensembl; ENSDART00000171996.2; ENSDARP00000137464.1; ENSDARG00000099766.2.
DR GeneID; 326719; -.
DR KEGG; dre:326719; -.
DR AGR; ZFIN:ZDB-GENE-030131-4918; -.
DR CTD; 326719; -.
DR ZFIN; ZDB-GENE-030131-4918; myl12.1.
DR eggNOG; KOG0031; Eukaryota.
DR HOGENOM; CLU_061288_9_3_1; -.
DR OMA; ETFNMID; -.
DR OrthoDB; 312751at2759; -.
DR TreeFam; TF314218; -.
DR Reactome; R-DRE-445355; Smooth Muscle Contraction.
DR Reactome; R-DRE-5627123; RHO GTPases activate PAKs.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000099766; Expressed in mature ovarian follicle and 25 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR23049:SF71; MYOSIN REGULATORY LIGHT CHAIN 12B; 1.
DR PANTHER; PTHR23049; MYOSIN REGULATORY LIGHT CHAIN 2; 1.
DR Pfam; PF13405; EF-hand_6; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6PHJ8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 29..64
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 98..133
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 172 AA; 19845 MW; B9190011DF50A038 CRC64;
MSSKRAKGKI TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID KEDLHDMLAS
LGKNPADDYL EAMMTEAPGP INFTMFLTMF GEKLNGTDPE EVIRNAFACF DEEGTGFIHE
DYLRELLTTM GDRFTDEEVD ELFREAPIDK KSNFNYVEFT RILKHGAKDK DD
//
