ID Q6QBS2_HUMAN Unreviewed; 53 AA.
AC Q6QBS2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=Epidermal growth factor {ECO:0000313|EMBL:AAS83395.1};
DE Flags: Fragment;
GN Name=EGF {ECO:0000313|EMBL:AAS83395.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAS83395.1};
RN [1] {ECO:0000313|EMBL:AAS83395.1}
RP NUCLEOTIDE SEQUENCE.
RA Nguyen N.L., Do Q.H., Vu M.T., Nguyen B.N., Phan V.C.;
RT "Cloning of a gene encoding for a human epidermal growth factor.";
RL Y Hoc Viet Nam 298:43-45(2004).
RN [2] {ECO:0000313|EMBL:AFA26280.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24413989; DOI=10.1007/s11033-013-2989-1;
RA Khan M.A., Khan F., Ahmad N., Khan M.I., Zafar A.U., Husnain T.;
RT "Expression line approach to recombinant human epidermal growth factor into
RT the yeast, Pichia pastoris from Huh-7 cell line.";
RL Mol. Biol. Rep. 41:1445-1451(2014).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AY548762; AAS83395.1; -; mRNA.
DR EMBL; JQ346088; AFA26280.1; -; mRNA.
DR AlphaFoldDB; Q6QBS2; -.
DR SMR; Q6QBS2; -.
DR PeptideAtlas; Q6QBS2; -.
DR ChiTaRS; EGF; human.
DR EvolutionaryTrace; Q6QBS2; -.
DR GO; GO:0030669; C:clathrin-coated endocytic vesicle membrane; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR10740:SF14; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10740; TRANSFORMING GROWTH FACTOR ALPHA; 1.
DR Pfam; PF00008; EGF; 1.
DR PRINTS; PR00009; EGFTGF.
DR SMART; SM00181; EGF; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030}.
FT DOMAIN 2..43
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 14..31
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 33..42
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAS83395.1"
FT NON_TER 53
FT /evidence="ECO:0000313|EMBL:AAS83395.1"
SQ SEQUENCE 53 AA; 6222 MW; 7D6A8806D873B071 CRC64;
NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW ELR
//
