ID Q6QM15_STRPU Unreviewed; 379 AA.
AC Q6QM15;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=Adenylate cyclase-stimulating G alpha protein {ECO:0000256|ARBA:ARBA00042247};
OS Strongylocentrotus purpuratus (Purple sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC Strongylocentrotus.
OX NCBI_TaxID=7668 {ECO:0000313|EMBL:AAS38582.1};
RN [1] {ECO:0000313|EMBL:AAS38582.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Ovary {ECO:0000313|EMBL:AAS38582.1};
RX PubMed=15003628; DOI=10.1016/j.mod.2004.01.005;
RA Voronina E., Wessel G.M.;
RT "Regulatory contribution of heterotrimeric G-proteins to oocyte maturation
RT in the sea urchin.";
RL Mech. Dev. 121:247-259(2004).
RN [2] {ECO:0000313|Proteomes:UP000007110}
RP NUCLEOTIDE SEQUENCE.
RA Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA Muzny D.M., Worley K.C., Gibbs R.A.;
RT "Genome sequencing for Strongylocentrotus purpuratus.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:NP_001001474}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The
CC alpha chain contains the guanine nucleotide binding site.
CC {ECO:0000256|ARBA:ARBA00011356}.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(s) subfamily.
CC {ECO:0000256|ARBA:ARBA00007172}.
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DR EMBL; AY534105; AAS38582.1; -; mRNA.
DR RefSeq; NP_001001474.1; NM_001001474.2.
DR AlphaFoldDB; Q6QM15; -.
DR STRING; 7668.Q6QM15; -.
DR EnsemblMetazoa; NM_001001474; NP_001001474; LOC414053.
DR GeneID; 414053; -.
DR KEGG; spu:414053; -.
DR CTD; 2774; -.
DR eggNOG; KOG0099; Eukaryota.
DR HOGENOM; CLU_014184_3_0_1; -.
DR InParanoid; Q6QM15; -.
DR OMA; DHVAKCW; -.
DR OrthoDB; 2897309at2759; -.
DR Proteomes; UP000007110; Unassembled WGS sequence.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IBA:GO_Central.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000367; Gprotein_alpha_S.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218:SF212; G PROTEIN ALPHA S SUBUNIT; 1.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00443; GPROTEINAS.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 2: Evidence at transcript level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000313|EMBL:AAS38582.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007110};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 379 AA; 44505 MW; A6256B198099CFE6 CRC64;
MGCFGNGLSS EEKDEEKKRK EANKKIEKQL QKDKQIYRAT HRLLLLGAGE SGKSTIVKQM
RILHVDGFSP DERKKKIEDI RRNIRDAIIT ITGAMSTLSP PIQLAEPQNQ FRLDYIQDVS
SSPDFDYPEE FWDHTKHLWI DAGVQGCYDR SHEYQLIDSA QYFLDRVDTI RRPDYAPDLQ
DILRCRVLTS GIFETKFQVD KVNFHMFDVG GQRDERRKWI QCFNDVTAII FVVACSSYNL
VLREDPNQNR LRESLELFRS IWNNRWLRTI SVILFLNKQD LLAEKVQAGR SKIEDYFSEY
AMYTIPPDAA TDTGEPEDVL RAKYFIRDEF LRISTASGDG RHYCYPHFTC AVDTENIRRV
FDDCRDIIQR MHLRQYELL
//
