ID TRP5_ARATH Reviewed; 630 AA.
AC Q6R0E3; Q9LNX7;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 27-MAR-2024, entry version 133.
DE RecName: Full=Telomere repeat-binding protein 5;
DE AltName: Full=Protein TRF-LIKE 2;
GN Name=TRP5; Synonyms=TRFL2; OrderedLocusNames=At1g07540; ORFNames=F22G5.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, DNA-BINDING, TISSUE SPECIFICITY, SUBUNIT, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=15364931; DOI=10.1074/jbc.m407938200;
RA Karamysheva Z.N., Surovtseva Y.V., Vespa L., Shakirov E.V., Shippen D.E.;
RT "A C-terminal Myb extension domain defines a novel family of double-strand
RT telomeric DNA-binding proteins in Arabidopsis.";
RL J. Biol. Chem. 279:47799-47807(2004).
RN [5]
RP GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
CC -!- FUNCTION: Binds specifically to the plant telomeric double-stranded DNA
CC sequences. At least 6 repeats of telomeric sequences are required for
CC binding.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:15364931}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously.
CC {ECO:0000269|PubMed:15364931}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype, probably due to redundancy.
CC {ECO:0000269|PubMed:15364931}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79547.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY519535; AAS10005.1; -; mRNA.
DR EMBL; AC022464; AAF79547.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28140.1; -; Genomic_DNA.
DR PIR; A86210; A86210.
DR RefSeq; NP_001318943.1; NM_001331707.1.
DR AlphaFoldDB; Q6R0E3; -.
DR SMR; Q6R0E3; -.
DR BioGRID; 22509; 3.
DR STRING; 3702.Q6R0E3; -.
DR PaxDb; 3702-AT1G07540-1; -.
DR EnsemblPlants; AT1G07540.1; AT1G07540.1; AT1G07540.
DR GeneID; 837268; -.
DR Gramene; AT1G07540.1; AT1G07540.1; AT1G07540.
DR KEGG; ath:AT1G07540; -.
DR Araport; AT1G07540; -.
DR TAIR; AT1G07540; TRFL2.
DR eggNOG; ENOG502QPSZ; Eukaryota.
DR HOGENOM; CLU_020710_2_0_1; -.
DR InParanoid; Q6R0E3; -.
DR OMA; NEDQCAV; -.
DR OrthoDB; 298800at2759; -.
DR PhylomeDB; Q6R0E3; -.
DR PRO; PR:Q6R0E3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6R0E3; baseline and differential.
DR Genevisible; Q6R0E3; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:UniProt.
DR CDD; cd11660; SANT_TRF; 1.
DR Gene3D; 1.10.246.220; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR031105; TRP_plant.
DR PANTHER; PTHR21717:SF86; TELOMERE REPEAT-BINDING PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR21717; TELOMERIC REPEAT BINDING PROTEIN; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..630
FT /note="Telomere repeat-binding protein 5"
FT /id="PRO_0000394128"
FT DOMAIN 354..433
FT /note="Ubiquitin-like"
FT DOMAIN 523..582
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 551..578
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 630
FT /note="L -> Q (in Ref. 1; AAS10005)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 630 AA; 70186 MW; 2AD2CB18AEDBA0B4 CRC64;
MVLQKRPDYG FNGYEVPHTP RAARSPRKSA FKKKSENHQI SSFDLLAAVA GKLLLEGGNS
SSSSNNTSGN NEDQCAVKKE PLNGGDIMVE EETTNSDHDN NNAERSFFVS EILQKSHEMQ
SFNRSPSPLK EFHFGSSSGI TSDSSEKFET QELAYDESKI NNGDCYRSES NDKKSMLGGL
NFEAKLSRNV VGKDEKHIGS GFRKPIPQNP STCSDDVDLH GKENDDGENF SACYRTKSFR
STLRIGDRRI RKVWASKYCK VPPKLKDTTV TNSDLDLKSD YYSKKHCLKS LRSERNYPIK
KRRYFDGYTA SQSEETNKNE GQSGSPRKAS AFLSSIACQK QPAAFQSPRD SNNVKLGIKS
FRVPELFIEI PETATVGSLK RTVLEAVTSI LGGGLRIGVL VHGKKVRDDS KMLLQTGLSL
DTLSDTLGFC LEPNPPQSTK PLSPEDSDFA RPCNVPHTLT RCLPSPGKHA KPSNSVESDL
DSKPSAPNRG KTIYSRALIP VSPLHAQALT VVPPRKTKRS EVAQRRIRRP FSVAEVEALV
QAVERLGTGR WRDVKLRAFD NAKHRTYVDL KDKWKTLVHT ARISPQQRRG EPVPQELLDR
VLTAHAYWSQ QQGKHQLLEG PQQLETSLGL
//
