ID Q6R5Y7_9ALPH Unreviewed; 313 AA.
AC Q6R5Y7;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=UL2 {ECO:0000313|EMBL:ABF72233.1, ECO:0000313|EMBL:ABR13076.1};
DE SubName: Full=Uracil-DNA glycosylase {ECO:0000313|EMBL:AAS01641.1, ECO:0000313|EMBL:AFM74568.1};
GN Name=UL2 {ECO:0000313|EMBL:AAS01641.1};
GN ORFNames=MDV014 {ECO:0000313|EMBL:ABF72233.1};
OS Gallid alphaherpesvirus 2.
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Mardivirus;
OC Mardivirus gallidalpha2.
OX NCBI_TaxID=10390 {ECO:0000313|EMBL:AAS01641.1, ECO:0000313|Proteomes:UP000155729};
RN [1] {ECO:0000313|EMBL:AAS01641.1, ECO:0000313|Proteomes:UP000155729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Md11 {ECO:0000313|EMBL:AAS01641.1};
RX PubMed=16155725; DOI=10.1007/s00705-005-0633-7;
RA Niikura M., Dodgson J., Cheng H.;
RT "Direct evidence of host genome acquisition by the alphaherpesvirus Marek's
RT disease virus.";
RL Arch. Virol. 151:537-549(2006).
RN [2] {ECO:0000313|EMBL:ACF94953.1, ECO:0000313|Proteomes:UP000134498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CU-2 {ECO:0000313|EMBL:ACF94953.1};
RX PubMed=17557133; DOI=10.1007/s00705-007-0992-3;
RA Spatz S.J., Silva R.F.;
RT "Sequence determination of variable regions within the genomes of gallid
RT herpesvirus-2 pathotypes.";
RL Arch. Virol. 152:1665-1678(2007).
RN [3] {ECO:0000313|EMBL:ABF72233.1, ECO:0000313|Proteomes:UP000149312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CVI988 {ECO:0000313|EMBL:ABF72233.1};
RX PubMed=17374751; DOI=10.1099/vir.0.82600-0;
RA Spatz S.J., Petherbridge L., Zhao Y., Nair V.;
RT "Comparative full-length sequence analysis of oncogenic and vaccine
RT (Rispens) strains of Marek's disease virus.";
RL J. Gen. Virol. 88:1080-1096(2007).
RN [4] {ECO:0000313|EMBL:ABR13076.1, ECO:0000313|Proteomes:UP000143489}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RB-1B {ECO:0000313|EMBL:ABR13076.1};
RX PubMed=17721813; DOI=10.1007/s11262-007-0157-1;
RA Spatz S.J., Zhao Y., Petherbridge L., Smith L.P., Baigent S.J., Nair V.;
RT "Comparative sequence analysis of a highly oncogenic but horizontal spread-
RT defective clone of Marek's disease virus.";
RL Virus Genes 35:753-766(2007).
RN [5] {ECO:0000313|EMBL:ACF94953.1, ECO:0000313|Proteomes:UP000134498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CU-2 {ECO:0000313|EMBL:ACF94953.1};
RX PubMed=18351449; DOI=10.1007/s11262-008-0213-5;
RA Spatz S.J., Rue C.A.;
RT "Sequence determination of a mildly virulent strain (CU-2) of Gallid
RT herpesvirus type 2 using 454 pyrosequencing.";
RL Virus Genes 36:479-489(2008).
RN [6] {ECO:0000313|EMBL:AEZ51653.1, ECO:0000313|Proteomes:UP000133397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMS {ECO:0000313|EMBL:AEZ51653.1};
RX PubMed=22476905; DOI=10.1007/s11262-012-0739-4;
RA Cheng Y., Cong F., Zhang Y.P., Li Z.J., Xu N.N., Hou G.Y., Liu C.J.;
RT "Genome sequence determination and analysis of a Chinese virulent strain,
RT LMS, of Gallid herpesvirus type 2.";
RL Virus Genes 45:56-62(2012).
RN [7] {ECO:0000313|Proteomes:UP000134084, ECO:0000313|Proteomes:UP000180864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=648a {ECO:0000313|EMBL:AFM74568.1};
RX PubMed=22923089; DOI=10.1007/s11262-012-0792-z;
RA Spatz S.J., Volkening J.D., Gimeno I.M., Heidari M., Witter R.L.;
RT "Dynamic equilibrium of Marek's disease genomes during in vitro serial
RT passage.";
RL Virus Genes 45:526-536(2012).
RN [8] {ECO:0000313|Proteomes:UP000103059, ECO:0000313|Proteomes:UP000127183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMd5 REV LTR BAC p10 {ECO:0000313|EMBL:ALX80949.1}, and RMd5
RC REV LTR BAC p70 {ECO:0000313|EMBL:ALX81067.1};
RA Mays J.K., Black-Pyrkosz A., Spatz S., Fadly A.M., Dunn J.R.;
RT "Protective Efficacy of a Recombinant Bacterial Artificial Chromosome Clone
RT of a Very Virulent Marek's Disease Virus Containing a Reticuloendothelial
RT Virus Long terminal Repeat.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:AUB50914.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATE2539 {ECO:0000313|EMBL:AUB50914.1}, EU-1
RC {ECO:0000313|EMBL:AUB50999.1}, and Polen5
RC {ECO:0000313|EMBL:AUB51169.1};
RX PubMed=29151863; DOI=10.1111/eva.12515;
RA Trimpert J., Groenke N., Jenckel M., He S., Kunec D., Szpara M.L.,
RA Spatz S.J., Osterrieder N., McMahon D.P.;
RT "A phylogenomic analysis of Marek's disease virus reveals independent paths
RT to virulence in Eurasia and North America.";
RL Evol. Appl. 10:1091-1101(2017).
RN [10] {ECO:0000313|EMBL:QOT13986.1}
RP NUCLEOTIDE SEQUENCE.
RA Conradie A.M., Bertzbach L.D., Trimpert J.D., Patria J.N., Murata S.,
RA Parcells M.S., Kaufer B.B.;
RT "Distinct polymorphisms in a single herpesvirus gene are capable of
RT enhancing virulence and mediate vaccinal resistance.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:QOT14172.1}
RP NUCLEOTIDE SEQUENCE.
RA Conradie A.M., Bertzbach L.D., Trimpert J., Patria J.N., Murata S.,
RA Parcells M.S., Kaufer B.B.;
RT "Distinct polymorphisms in a single herpesvirus gene are capable of
RT enhancing virulence and mediate vaccinal resistance.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:QOT14726.1}
RP NUCLEOTIDE SEQUENCE.
RA Conradie A.M., Kaufer B.;
RT "Marek's disease virus requires both copies of the inverted repeat regions
RT for efficient in vivo replication and pathogenesis.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:QOT14858.1}
RP NUCLEOTIDE SEQUENCE.
RA Vychodil T., Conradie A.M., Trimpert J., Aswad A., Bertzbach L.D.,
RA Kaufer B.;
RT "Functional analysis of genomic repeat regions in Marek's disease virus
RT replication and pathogenesis.";
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC UNG family. {ECO:0000256|ARBA:ARBA00008184}.
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DR EMBL; AY510475; AAS01641.1; -; Genomic_DNA.
DR EMBL; DQ530348; ABF72233.1; -; Genomic_DNA.
DR EMBL; EF523390; ABR13076.1; -; Genomic_DNA.
DR EMBL; EU499381; ACF94953.1; -; Genomic_DNA.
DR EMBL; JQ314003; AEZ51653.1; -; Genomic_DNA.
DR EMBL; JQ806361; AFM74568.1; -; Genomic_DNA.
DR EMBL; JQ806362; AFM74755.1; -; Genomic_DNA.
DR EMBL; JQ809691; AFM74945.1; -; Genomic_DNA.
DR EMBL; JQ809692; AFM75132.1; -; Genomic_DNA.
DR EMBL; JQ820250; AFM75313.1; -; Genomic_DNA.
DR EMBL; JQ836662; AFM75491.1; -; Genomic_DNA.
DR EMBL; KT833851; ALX80949.1; -; Genomic_DNA.
DR EMBL; KT833852; ALX81067.1; -; Genomic_DNA.
DR EMBL; MF431493; AUB50914.1; -; Genomic_DNA.
DR EMBL; MF431494; AUB50999.1; -; Genomic_DNA.
DR EMBL; MF431496; AUB51169.1; -; Genomic_DNA.
DR EMBL; MT797629; QOT13986.1; -; Genomic_DNA.
DR EMBL; MT797630; QOT14172.1; -; Genomic_DNA.
DR EMBL; MT797631; QOT14358.1; -; Genomic_DNA.
DR EMBL; MT813453; QOT14541.1; -; Genomic_DNA.
DR EMBL; MT872313; QOT14726.1; -; Genomic_DNA.
DR EMBL; MT955328; QOT14858.1; -; Genomic_DNA.
DR EMBL; MT994392; QOT14999.1; -; Genomic_DNA.
DR RefSeq; YP_001033930.1; NC_002229.3.
DR GeneID; 4811475; -.
DR KEGG; vg:4811475; -.
DR OrthoDB; 11388at10239; -.
DR Proteomes; UP000103059; Genome.
DR Proteomes; UP000127183; Genome.
DR Proteomes; UP000133397; Genome.
DR Proteomes; UP000134084; Genome.
DR Proteomes; UP000134498; Genome.
DR Proteomes; UP000143489; Genome.
DR Proteomes; UP000149312; Genome.
DR Proteomes; UP000155729; Genome.
DR Proteomes; UP000180864; Genome.
DR Proteomes; UP000180974; Genome.
DR Proteomes; UP000181470; Genome.
DR Proteomes; UP000181580; Genome.
DR Proteomes; UP000181598; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR CDD; cd10027; UDG-F1-like; 1.
DR Gene3D; 3.40.470.10; Uracil-DNA glycosylase-like domain; 1.
DR HAMAP; MF_00148; UDG; 1.
DR InterPro; IPR002043; UDG_fam1.
DR InterPro; IPR018085; Ura-DNA_Glyclase_AS.
DR InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR NCBIfam; TIGR00628; ung; 1.
DR PANTHER; PTHR11264; URACIL-DNA GLYCOSYLASE; 1.
DR PANTHER; PTHR11264:SF0; URACIL-DNA GLYCOSYLASE; 1.
DR Pfam; PF03167; UDG; 1.
DR SMART; SM00986; UDG; 1.
DR SMART; SM00987; UreE_C; 1.
DR SUPFAM; SSF52141; Uracil-DNA glycosylase-like; 1.
DR PROSITE; PS00130; U_DNA_GLYCOSYLASE; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000155729}.
FT DOMAIN 138..299
FT /note="Uracil-DNA glycosylase-like"
FT /evidence="ECO:0000259|SMART:SM00986"
FT REGION 35..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 153
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10072"
SQ SEQUENCE 313 AA; 34805 MW; 217289AEAC09BE2D CRC64;
MAQLDLTGLT ETSKMIVGEC HVELKRCAEP PLAADEPMPK KCRRPAGPPK GFISTRGDTS
PSSDNNHIHS IQSLTNGDSC VQPWDIIANA YNIHENWKQL LLPELCCLRG SEILAEYERR
AITEEVYPPK MDIFAWTRYC APESVKAVIV GQDPYANPGQ AHGLAFSVKQ GVAIPPSLKN
ILLAVKACYP SADLGNHGCL EAWSKRGVLL LNSVLTVKRG DPGSHHSVGW QFFIRNILRR
LSSTTRGIVF MLWGAQAQTM YFQTDYDDRH LVLKYSHPSP LSRKPFATCT HFKEANDFLS
KIGRGCIDWS LTA
//
