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Database: UniProt
Entry: Q6R786_9HIV2
LinkDB: Q6R786_9HIV2
Original site: Q6R786_9HIV2 
ID   Q6R786_9HIV2            Unreviewed;       256 AA.
AC   Q6R786;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   12-AUG-2020, entry version 70.
DE   RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344};
GN   Name=nef {ECO:0000313|EMBL:AAR98767.1};
OS   Human immunodeficiency virus 2.
OC   Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11709 {ECO:0000313|EMBL:AAR98767.1, ECO:0000313|Proteomes:UP000259955};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAR98767.1, ECO:0000313|Proteomes:UP000259955}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14747565; DOI=10.1128/JVI.78.4.2006-2016.2004;
RA   Schmitz C., Marchant D., Neil S.J., Aubin K., Reuter S., Dittmar M.T.,
RA   McKnight A.;
RT   "Lv2, a novel postentry restriction, is mediated by both capsid and
RT   envelope.";
RL   J. Virol. 78:2006-2016(2004).
CC   -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein family.
CC       {ECO:0000256|ARBA:ARBA00006933, ECO:0000256|RuleBase:RU000344}.
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DR   EMBL; AY509259; AAR98767.1; -; Genomic_DNA.
DR   Proteomes; UP000259955; Chromosome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0030683; P:mitigation of host immune response by virus; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.62.10; -; 1.
DR   InterPro; IPR027481; HIV-1_Nef_core_sf.
DR   InterPro; IPR001558; HIV_Nef.
DR   Pfam; PF00469; F-protein; 1.
DR   SUPFAM; SSF55671; SSF55671; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Lipoprotein {ECO:0000256|RuleBase:RU000344};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707, ECO:0000256|RuleBase:RU000344};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280,
KW   ECO:0000256|RuleBase:RU000344};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026, ECO:0000256|RuleBase:RU000344}.
FT   REGION          1..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..25
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..68
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..90
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   256 AA;  29475 MW;  FB454C4278E46C1E CRC64;
     MGASGSKERS RPSQGLRERL LRARGETCGG HCSGSGGEYL QSQEESGREQ RSPSYEGQRY
     QQGDFMNTPW RTPAKEGEKE LYKQQNRDDV DSDDDDLVGV SVTPRVPLRE LTHRLAIDVS
     HFIKEKGGLE GMYYSERRHR ILDIYLEKEE GIIADWQNYT HGPGIRYPMF FGWLWKLVPV
     DVTRQEEDDG THCLLHPAQT SRFDDPHGET LIWKFDPTLA HDYKAFILHP EEFGHKSGLP
     EEDWKARLKA RGIPFS
//
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