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Database: UniProt
Entry: Q6R792_9HIV2
LinkDB: Q6R792_9HIV2
Original site: Q6R792_9HIV2 
ID   Q6R792_9HIV2            Unreviewed;       215 AA.
AC   Q6R792;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   10-FEB-2021, entry version 61.
DE   RecName: Full=Virion infectivity factor {ECO:0000256|RuleBase:RU003341};
GN   Name=vif {ECO:0000313|EMBL:AAR98761.1};
OS   Human immunodeficiency virus 2.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11709 {ECO:0000313|EMBL:AAR98761.1, ECO:0000313|Proteomes:UP000259955};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAR98761.1, ECO:0000313|Proteomes:UP000259955}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14747565; DOI=10.1128/JVI.78.4.2006-2016.2004;
RA   Schmitz C., Marchant D., Neil S.J., Aubin K., Reuter S., Dittmar M.T.,
RA   McKnight A.;
RT   "Lv2, a novel postentry restriction, is mediated by both capsid and
RT   envelope.";
RL   J. Virol. 78:2006-2016(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC       Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|RuleBase:RU003341};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004501,
CC       ECO:0000256|RuleBase:RU003341}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|RuleBase:RU003341}. Host
CC       cytoplasm {ECO:0000256|RuleBase:RU003341}. Virion
CC       {ECO:0000256|RuleBase:RU003341}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}. Note=In the cytoplasm, seems to
CC       colocalize with intermediate filament vimentin. A fraction is
CC       associated with the cytoplasmic side of cellular membranes, presumably
CC       via the interaction with Pr55Gag precursor.
CC       {ECO:0000256|RuleBase:RU003341}.
CC   -!- SIMILARITY: Belongs to the primate lentivirus group Vif protein family.
CC       {ECO:0000256|ARBA:ARBA00006372, ECO:0000256|RuleBase:RU003341}.
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DR   EMBL; AY509259; AAR98761.1; -; Genomic_DNA.
DR   Proteomes; UP000259955; Chromosome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
DR   GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR   InterPro; IPR000475; Vif.
DR   Pfam; PF00559; Vif; 1.
DR   PRINTS; PR00349; VIRIONINFFCT.
PE   3: Inferred from homology;
KW   Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
SQ   SEQUENCE   215 AA;  25298 MW;  F4E1811CC34C49C9 CRC64;
     MEEGKNWIVV PTWRVPGRME KWHSLVKYLK YRTKDLEDVC YVPHHKVGWA WWTCSRVIFP
     LKGNSHLEIQ AYWNLTPEKG WLSSYSVRMT WYTERFWTDV TPDCADSLIH STYFSCFTAG
     EVRRAIRGEK LLSCCNYPQA HRAQVPSLQF LALVVVQQND RPQRNGTPRK QWRRDYRRGL
     QLARQDGRSH KQRGSESPAP RAYFPGVAEV LEILA
//
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