ID Q6RYB7_ICTPU Unreviewed; 120 AA.
AC Q6RYB7;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Pro-glucagon precursor {ECO:0000313|RefSeq:NP_001187117.1};
DE SubName: Full=Proglucagon II {ECO:0000313|EMBL:AAS57650.1};
GN Name=gcgb {ECO:0000313|RefSeq:NP_001187117.1};
GN Synonyms=gcg {ECO:0000313|RefSeq:NP_001187117.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AAS57650.1};
RN [1] {ECO:0000313|EMBL:AAS57650.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Intestine {ECO:0000313|EMBL:AAS57650.1};
RA Busby E.R., Mommsen T.P.;
RT "Proglucagon expression and distribution in channel catfish.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001187117.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [3] {ECO:0000313|RefSeq:NP_001187117.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR EMBL; AY485814; AAS57650.1; -; mRNA.
DR RefSeq; NP_001187117.1; NM_001200188.2.
DR STRING; 7998.ENSIPUP00000020030; -.
DR Ensembl; ENSIPUT00000020897; ENSIPUP00000020030; ENSIPUG00000013580.
DR GeneID; 100304622; -.
DR KEGG; ipu:100304622; -.
DR CTD; 436584; -.
DR OMA; MNTKRNX; -.
DR OrthoDB; 5318261at2759; -.
DR Proteomes; UP000221080; Chromosome 6.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR Gene3D; 6.10.250.590; -; 2.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11418; GLUCAGON; 1.
DR PANTHER; PTHR11418:SF0; PRO-GLUCAGON; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 2.
PE 2: Evidence at transcript level;
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001187117.1}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..120
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001187117.1"
FT /id="PRO_5011323863"
FT DOMAIN 49..71
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT DOMAIN 87..109
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
SQ SEQUENCE 120 AA; 13990 MW; 063C74441112BA0D CRC64;
MKSIQYLAGL LLLIIVQSSW QIPIDDTEEN SSVMLEDTLL NNPTYMKRHS EGTFSNDYSK
YLETRRAQDF IQWLMNSKRS GSHTRRHADG TYTSDVSSYM QDQAAKEFVS WLKMGRGRRE
//
