ID ETR4_ORYSI Reviewed; 777 AA.
AC Q6T5K3;
DT 16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=Ethylene receptor 4 {ECO:0000305};
DE Short=OS-ETR4 {ECO:0000303|PubMed:14754915};
DE EC=2.7.13.3 {ECO:0000305};
GN Name=ETR4 {ECO:0000312|EMBL:AAR08914.1};
GN ORFNames=OsI_25565 {ECO:0000312|EMBL:EAZ03426.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. IR36;
RX PubMed=14754915; DOI=10.1093/jxb/erh055;
RA Yau C.P., Wang L., Yu M., Zee S.Y., Yip W.K.;
RT "Differential expression of three genes encoding an ethylene receptor in
RT rice during development, and in response to indole-3-acetic acid and silver
RT ions.";
RL J. Exp. Bot. 55:547-556(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Ethylene receptor related to bacterial two-component
CC regulators. Acts as a redundant negative regulator of ethylene
CC signaling. {ECO:0000250|UniProtKB:P49333}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000305};
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000250|UniProtKB:P49333};
CC Note=Binds 1 copper ion per dimer. {ECO:0000250|UniProtKB:P49333};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P49333}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ethylene receptor family. {ECO:0000305}.
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DR EMBL; AY434734; AAR08914.1; -; mRNA.
DR EMBL; CM000132; EAZ03426.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6T5K3; -.
DR STRING; 39946.Q6T5K3; -.
DR EnsemblPlants; BGIOSGA024506-TA; BGIOSGA024506-PA; BGIOSGA024506.
DR Gramene; BGIOSGA024506-TA; BGIOSGA024506-PA; BGIOSGA024506.
DR HOGENOM; CLU_000445_114_48_1; -.
DR OMA; ACAVWMP; -.
DR Proteomes; UP000007015; Chromosome 7.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051740; F:ethylene binding; IEA:InterPro.
DR GO; GO:0038199; F:ethylene receptor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16938; HATPase_ETR2_ERS2-EIN4-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR014525; ETR.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR24423:SF618; ETHYLENE RECEPTOR 4; 1.
DR PANTHER; PTHR24423; TWO-COMPONENT SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PIRSF; PIRSF026389; Ethyln_sen_HK; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Copper; Endoplasmic reticulum; Ethylene signaling pathway;
KW Kinase; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein;
KW Receptor; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix; Two-component regulatory system.
FT CHAIN 1..777
FT /note="Ethylene receptor 4"
FT /id="PRO_0000433870"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 184..344
FT /note="GAF"
FT /evidence="ECO:0000305"
FT DOMAIN 387..521
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT DOMAIN 645..774
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT BINDING 88
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT BINDING 92
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT MOD_RES 390
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT MOD_RES 696
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 777 AA; 83327 MW; 399D1684558AC117 CRC64;
MAMVTARQFL ASAAELGSGR RRCGGGGACD MREDGGVEAL MQCQRVSNLL IAASFLSIPL
ELFYFATCAD LSEVKCAVLH FCAFIVLCGA THLLAAFTHA HPHSAPLLRA LTAAKVLAAV
ASSAAAVSLL TFIPKLLRIK VRESLLRDKA SRLHRDLGLV RRREEATSRA VRELTGRIRA
SPPDAHAILR TTALQLADAL GLHACAVWMP AAGRPHDLVL VHHLTSRPDD AADLLLEVGD
ACTVAADDPD VVDVMASKVA KVLEPDSALA MASSVGAAPA GAVAAIRIPI LRVSIYDGGG
TPEVTEASYA ILVLLLPPHD AAGGWSSHDL EIVQVVADQA AVALSHAAVL EESRSMRDRF
AEQHRALMQA KHRAAMATRA FSSIQSAMCH AMRRPVHSIV GLVSMLQHPE ADTMRPEQRL
AVDAIARTSN LLSALMDEVI VNRQHLSVQR KPFSLHALIK EAISVAGCLS HCGGAGFLHQ
LECALPEWVV GDERRVFHLL LDMVGTLLNR CNTESGACRL SFSIRICNVG EERYSLDWIP
MRPTFSGCNV CVKFKVGIGR SRSCAIERSL PCELPRRSAA TTSSQMGHIF SGYFNKIVQM
MNGNMWSASD SEGVGESVTL ILQFKLQQGH VEASPPYIPH LNGLRVLLAD DDAMNRGVTK
KILERLGCQV MSAPSGAHCL SLLASAEASF QLVVLDLDDR AVPSAAMDGF EVALRIRELR
YSCWLLIVIA VAAGVVATDD GGAVQELCQR AGINGLVQKP VTLPALGAQL CRVLQDN
//
