GenomeNet

Database: UniProt
Entry: Q6TUQ9
LinkDB: Q6TUQ9
Original site: Q6TUQ9 
ID   A18_YMTV5               Reviewed;         478 AA.
AC   Q6TUQ9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   18-SEP-2019, entry version 63.
DE   RecName: Full=Transcript termination protein A18;
DE            EC=3.6.4.-;
GN   OrderedLocusNames=110R;
OS   Yaba monkey tumor virus (strain VR587) (YMTV).
OC   Viruses; Poxviridae; Chordopoxvirinae; Yatapoxvirus.
OX   NCBI_TaxID=928314;
OH   NCBI_TaxID=9538; Erythrocebus patas (Red guenon) (Cercopithecus patas).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9539; Macaca (macaques).
OH   NCBI_TaxID=9557; Papio hamadryas (Hamadryas baboon).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14645589; DOI=10.1128/jvi.77.24.13335-13347.2003;
RA   Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T.,
RA   Li X., Barrett J.W., McFadden G.;
RT   "Complete genomic sequence and comparative analysis of the tumorigenic
RT   poxvirus Yaba monkey tumor virus.";
RL   J. Virol. 77:13335-13347(2003).
CC   -!- FUNCTION: DNA helicase which seems to act as a postreplicative
CC       transcription termination factor. Involved in ATP-dependent
CC       release of nascent RNA. Forms a stable complex with single-
CC       stranded DNA, and to a lesser extent RNA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with G2. Might be part of a transcription
CC       complex composed at least of G2, A18, and H5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes to the
CC       virion core. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the helicase family. Poxviruses subfamily.
CC       {ECO:0000305}.
DR   EMBL; AY386371; AAR07466.1; -; Genomic_DNA.
DR   RefSeq; NP_938365.1; NC_005179.1.
DR   SMR; Q6TUQ9; -.
DR   PRIDE; Q6TUQ9; -.
DR   GeneID; 2943580; -.
DR   KEGG; vg:2943580; -.
DR   Proteomes; UP000008596; Genome.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA-binding; Helicase; Hydrolase;
KW   Late protein; Nucleotide-binding; Reference proteome; Transcription;
KW   Virion.
FT   CHAIN         1    478       Transcript termination protein A18.
FT                                /FTId=PRO_0000102190.
FT   DOMAIN       98    254       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      307    454       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     111    118       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       204    207       DESH box.
SQ   SEQUENCE   478 AA;  55285 MW;  5961D49A3A5F429E CRC64;
     MSVCTEIDYK LYTELRKIAG NSLFLFNEDG DFVEVVSNSS FKFLLPVGLF SSMDIPLKKP
     IECNTDNDIE HSKNVVMPNL YPFQERVASE VLSSIKKKVE LKRPMYVTLH LACGFGKTIT
     TCYLLSVHKK KAVICLPNKM LINQWKRAIE SININHLVSV DGVGNLLKEL VKKPADILII
     VSRHLSNKEF CKKIHVDYDV FVLDESHMYN LMNNSTVTRF LTYYPPKICY FLTATPRRVN
     RIYCNDVINV SNSSDLKKYI KIVEFFFETY SSDTIRQMVK KLNTNYNKYH MYTEKILAED
     VPRNKLILDT IIYDFEKMIV NRLIIVTKLR KHMMFFYTNL IEKFGSDIVY LGDAKNKNIS
     DIVKKIKSIN RFIFISTTNY SGTGLDVPTL DSLVICSAVM NSMQIEQILG RICRYSISKT
     RTVIVFPNTS IKEIKHMIGF FTQKIITLAI EKLGFKKIDK KGNKQEFALC KAFNLQTR
//
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