ID Q6UK11_9ALPH Unreviewed; 577 AA.
AC Q6UK11; Q5PP81;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 88.
DE RecName: Full=Envelope glycoprotein E {ECO:0000256|ARBA:ARBA00013988};
GN Name=US8 {ECO:0000313|EMBL:AAQ86800.1};
OS Suid alphaherpesvirus 1.
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Varicellovirus;
OC Varicellovirus suidalpha1.
OX NCBI_TaxID=10345 {ECO:0000313|EMBL:AAQ86800.1};
RN [1] {ECO:0000313|EMBL:AAQ86800.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Becker {ECO:0000313|EMBL:AAQ86800.1};
RA Husak P.J., Brideau A.D., Enquist L.W.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAQ86800.1, ECO:0000313|Proteomes:UP000165522}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Becker {ECO:0000313|EMBL:AAQ86800.1};
RX PubMed=14671123; DOI=10.1128/JVI.78.1.424-440.2004;
RA Klupp B.G., Hengartner C.J., Mettenleiter T.C., Enquist L.W.;
RT "Complete, annotated sequence of the pseudorabies virus genome.";
RL J. Virol. 78:424-440(2004).
RN [3] {ECO:0000313|EMBL:AEM64110.1, ECO:0000313|Proteomes:UP000154030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Becker {ECO:0000313|EMBL:AEM64110.1};
RX PubMed=22022263; DOI=10.1371/journal.ppat.1002282;
RA Szpara M.L., Tafuri Y.R., Parsons L., Shamim S.R., Verstrepen K.J.,
RA Legendre M., Enquist L.W.;
RT "A wide extent of inter-strain diversity in virulent and vaccine strains of
RT alphaherpesviruses.";
RL PLoS Pathog. 7:E1002282-E1002282(2011).
CC -!- FUNCTION: In epithelial cells, the heterodimer gE/gI is required for
CC the cell-to-cell spread of the virus, by sorting nascent virions to
CC cell junctions. Once the virus reaches the cell junctions, virus
CC particles can spread to adjacent cells extremely rapidly through
CC interactions with cellular receptors that accumulate at these
CC junctions. Implicated in basolateral spread in polarized cells. In
CC neuronal cells, gE/gI is essential for the anterograde spread of the
CC infection throughout the host nervous system. Together with US9, the
CC heterodimer gE/gI is involved in the sorting and transport of viral
CC structural components toward axon tips.
CC {ECO:0000256|ARBA:ARBA00025134}.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Endosome membrane {ECO:0000256|ARBA:ARBA00004190}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004190}. Host Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004152}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004152}. Host cell junction
CC {ECO:0000256|ARBA:ARBA00004315}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004235}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004235}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein E family.
CC {ECO:0000256|ARBA:ARBA00008101}.
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DR EMBL; AY368490; AAQ86800.1; -; Genomic_DNA.
DR EMBL; JF797219; AEM64110.1; -; Genomic_DNA.
DR EMBL; BK001744; DAA02209.1; -; Genomic_DNA.
DR RefSeq; YP_068389.1; NC_006151.1.
DR SMR; Q6UK11; -.
DR IntAct; Q6UK11; 1.
DR GeneID; 2952517; -.
DR KEGG; vg:2952517; -.
DR OrthoDB; 7742at10239; -.
DR Proteomes; UP000154030; Genome.
DR Proteomes; UP000165522; Genome.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044156; C:host cell junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR003404; Herpes_glycopE_Fc.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF02480; Herpes_gE; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
PE 3: Inferred from homology;
KW Host cell junction {ECO:0000256|ARBA:ARBA00023081};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000154030};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT TRANSMEM 429..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 226..386
FT /note="Envelope glycoprotein E Fc-binding"
FT /evidence="ECO:0000259|Pfam:PF02480"
FT REGION 481..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 62411 MW; A07A4ACCBEA0F969 CRC64;
MRPFLLRAAQ LLALLALALS TEAPSLSAET TPGPVTEVPS PSAEVWDLST EAGDDDLDGD
LNGDDRRAGF GSALASLREA PPAHLVNVSE GANFTLDARG DGAVVAGIWT FLPVRGCDAV
AVTMVCFETA CHPDLVLGRA CVPEAPERGI GDYLPPEVPR LQREPPIVTP ERWSPHLTVR
RATPNDTGLY TLHDASGPRA VFFVAVGDRP PAPLAPVGPA RHEPRFHALG FHSQLFSPGD
TFDLMPRVVS DMGDSRENFT ATLDWYYARA PPRCLLYYVY EPCIYHPRAP ECLRPVDPAC
SFTSPARARL VARRAYASCS PLLGDRWLTA CPFDAFGEEV HTNATADESG LYVLVMTHNG
HVATWDYTLV ATAAEYVTVI KELTAPARAP GTPWGPGGGD DAIYVDGVTT PAPPARPWNP
YGRTTPGRLF VLALGSFVMT CVVGGAVWLC VLCSRRRAAS RPFRVPTRAG TRMLSPVYTS
LPTHEDYYDG DDDDEEAGDA RRRPSSPGGD SGYEGPYVSL DAEDEFSSDE DDGLYVRPEE
APRSGFDVWF RDPEKPEVTN GPNYGVTASR LLNARPA
//
