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Database: UniProt
Entry: Q6UKI2
LinkDB: Q6UKI2
Original site: Q6UKI2 
ID   AMNLS_CANLF             Reviewed;         458 AA.
AC   Q6UKI2;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 55.
DE   RecName: Full=Protein amnionless;
DE   Flags: Precursor;
GN   Name=AMN;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14576052; DOI=10.1182/blood-2003-08-2852;
RA   Fyfe J.C., Madsen M., Hoejrup P., Christensen E.I., Tanner S.M.,
RA   de la Chapelle A., He Q., Moestrup S.K.;
RT   "The functional cobalamin (vitamin B12)-intrinsic factor receptor is a
RT   novel complex of cubilin and amnionless.";
RL   Blood 103:1573-1579(2004).
RN   [2]
RP   POSSIBLE INVOLVEMENT IN CANINE MGA1.
RX   PubMed=14722725; DOI=10.1007/s00335-003-2280-1;
RA   He Q., Fyfe J.C., Schaeffer A.A., Kilkenney A., Werner P.,
RA   Kirkness E.F., Henthorn P.S.;
RT   "Canine Imerslund-Grasbeck syndrome maps to a region orthologous to
RT   HSA14q.";
RL   Mamm. Genome 14:758-764(2003).
CC   -!- FUNCTION: Necessary for efficient absorption of vitamin B12 (By
CC       similarity). Required for normal CUBN-mediated protein transport
CC       in the kidney. May direct the production of trunk mesoderm during
CC       development by modulating a bone morphogenetic protein (BMP)
CC       signaling pathway in the underlying visceral endoderm (By
CC       similarity). {ECO:0000250|UniProtKB:Q99JB7,
CC       ECO:0000250|UniProtKB:Q9BXJ7}.
CC   -!- SUBUNIT: Interacts with CUBN/cubilin.
CC       {ECO:0000250|UniProtKB:Q99JB7}.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q99JB7}; Single-pass type I membrane
CC       protein {ECO:0000250|UniProtKB:Q9BXJ7}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9BXJ7}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9BXJ7}. Endosome
CC       {ECO:0000250|UniProtKB:Q9BXJ7}. Membrane, coated pit
CC       {ECO:0000250|UniProtKB:Q9BXJ7}.
CC   -!- DISEASE: Note=Defects in AMN could be a cause of a canine form of
CC       megaloblastic anemia 1 (MGA1).
DR   EMBL; AY368152; AAR13399.1; -; mRNA.
DR   RefSeq; NP_001002960.1; NM_001002960.1.
DR   SMR; Q6UKI2; -.
DR   GeneID; 403434; -.
DR   KEGG; cfa:403434; -.
DR   CTD; 81693; -.
DR   InParanoid; Q6UKI2; -.
DR   KO; K18259; -.
DR   OrthoDB; 827066at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IMP:CACAO.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR026112; AMN.
DR   PANTHER; PTHR14995; PTHR14995; 1.
DR   Pfam; PF14828; Amnionless; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coated pit; Complete proteome; Developmental protein;
KW   Endosome; Glycoprotein; Membrane; Protein transport;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW   Transport.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    458       Protein amnionless.
FT                                /FTId=PRO_0000020701.
FT   TOPO_DOM     20    366       Extracellular. {ECO:0000255}.
FT   TRANSMEM    367    387       Helical. {ECO:0000255}.
FT   TOPO_DOM    388    458       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      203    254       VWFC.
FT   CARBOHYD     35     35       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   458 AA;  47618 MW;  4927E33B466B8D5A CRC64;
     MGALGRALLW LQLCALARAA YKLWVPTTDF EAAANWSQNR TPCAGAVVQF PADKAVSVVV
     RASHGFSDML LPRDGEFVLA SGAGFGAADA GRDPDCGAGA PALFLDPDRF SWHDPRLWRS
     GDAARGLFSV DAERVPCRHD DVVFPPDASF RVGLGPGARP ARVRSVQVLG QTFTRDEDLA
     AFLASRAGRL RFHGPGALRV GPGACADPSG CVCGDAEVQP WICAALLQPL GGRCPPAACP
     DALRPEGQCC DLCGAIVSLT HGPTFDIERY RARLLRAFLP QYPGLQAAVS KVRRRPGPHT
     EVQVVLAETG PQPGGAGRLA RALLADVAEH GEALGVLSAT ARESGAPVGD GSAAGPLGSG
     SRAGLAGGVA AGLLLLLLAL AAGLLLLRRA PRLRWTKRER LVATPVEAPL GFSNPVFDVA
     GSVGPVPRTP QPPPAQQAGS SSTSRSYFVN PLFAEAEA
//
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