ID Q6XQG7_SALSA Unreviewed; 175 AA.
AC Q6XQG7;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=IFNa1 {ECO:0000313|EMBL:ACE75690.1};
DE SubName: Full=Interferon alpha 1 {ECO:0000313|EMBL:AAP51035.1, ECO:0000313|RefSeq:NP_001117182.1};
GN Name=IFNA1 {ECO:0000313|EMBL:AAP51035.1};
GN Synonyms=ifna1 {ECO:0000313|RefSeq:NP_001117182.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:AAP51035.1};
RN [1] {ECO:0000313|EMBL:AAP51035.1, ECO:0000313|RefSeq:NP_001117182.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14585200; DOI=10.1089/107999003322485107;
RA Robertsen B., Bergan V., Rokenes T., Larsen R., Albuquerque A.;
RT "Atlantic salmon interferon genes: cloning, sequence analysis, expression,
RT and biological activity.";
RL J. Interferon Cytokine Res. 23:601-612(2003).
RN [2] {ECO:0000313|EMBL:ABD39320.1, ECO:0000313|RefSeq:NP_001117182.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Sperm {ECO:0000313|EMBL:ABD39320.1};
RX PubMed=16889635; DOI=10.1111/j.1742-4658.2006.05382.x;
RA Bergan V., Steinsvik S., Xu H., Kileng O., Robertsen B.;
RT "Promoters of type I interferon genes from Atlantic salmon contain two main
RT regulatory regions.";
RL FEBS J. 273:3893-3906(2006).
RN [3] {ECO:0000313|EMBL:ACE75690.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19007809; DOI=10.1016/j.dci.2008.10.001;
RA Sun B., Robertsen B., Wang Z., Liu B.;
RT "Identification of an Atlantic salmon IFN multigene cluster encoding three
RT IFN subtypes with very different expression properties.";
RL Dev. Comp. Immunol. 33:547-558(2009).
RN [4] {ECO:0000313|RefSeq:NP_001117182.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23169587; DOI=10.4049/jimmunol.1201188;
RA Svingerud T., Solstad T., Sun B., Nyrud M.L., Kileng O.,
RA Greiner-Tollersrud L., Robertsen B.;
RT "Atlantic salmon type I IFN subtypes show differences in antiviral activity
RT and cell-dependent expression: evidence for high IFNb/IFNc-producing cells
RT in fish lymphoid tissues.";
RL J. Immunol. 189:5912-5923(2012).
RN [5] {ECO:0000313|RefSeq:NP_001117182.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27530458;
RA Chang C.J., Jenssen I., Robertsen B.;
RT "Protection of Atlantic salmon against salmonid alphavirus infection by
RT type I interferons IFNa, IFNb and IFNc.";
RL Fish Shellfish Immunol. 57:35-40(2016).
RN [6] {ECO:0000313|RefSeq:NP_001117182.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC {ECO:0000256|RuleBase:RU000436}.
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DR EMBL; AY216594; AAP51035.1; -; mRNA.
DR EMBL; DQ354152; ABD39320.1; -; Genomic_DNA.
DR EMBL; EU768890; ACE75690.1; -; Genomic_DNA.
DR RefSeq; NP_001117182.1; NM_001123710.1.
DR GeneID; 100137019; -.
DR KEGG; sasa:100137019; -.
DR CTD; 3439; -.
DR OrthoDB; 4270115at2759; -.
DR Proteomes; UP000087266; Chromosome ssa28.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR GO; GO:0140374; P:antiviral innate immune response; IDA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IDA:AgBase.
DR GO; GO:1902615; P:immune response involved in response to exogenous dsRNA; IMP:AgBase.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:AgBase.
DR GO; GO:1904972; P:negative regulation of viral translation; IDA:AgBase.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IMP:AgBase.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:AgBase.
DR GO; GO:0060337; P:type I interferon-mediated signaling pathway; IDA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691:SF37; INTERFERON OMEGA-1; 1.
DR PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR Pfam; PF00143; Interferon; 1.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
KW ECO:0000256|RuleBase:RU000436}; Cytokine {ECO:0000256|RuleBase:RU000436};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001117182.1}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..175
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001117182.1"
FT /id="PRO_5009732071"
SQ SEQUENCE 175 AA; 20846 MW; 1D2202E6CEAD59B9 CRC64;
MYTVQSWTCI CLIICSMQSV CHCCDWIRHH YGHLSSEYLS LLDQMGGDIT KQDAPVFFPT
SLYRHIDDAE VEDQVRFLKE TIYQITKLFD GNMKSVTWDK KKLDDFLNIL ERQLENLKSC
VSPAMKPEKR LKRYFKKLNK NVLRKMNYSA QAWELIRKET KRHLQRLDIL AAQMY
//
