ID   Q6YQ70_ONYPE            Unreviewed;       873 AA.
AC   Q6YQ70;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 120.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   Name=uvrD {ECO:0000313|EMBL:BAD04590.1};
GN   OrderedLocusNames=PAM_505 {ECO:0000313|EMBL:BAD04590.1};
OS   Onion yellows phytoplasma (strain OY-M).
OC   Bacteria; Mycoplasmatota; Mollicutes; Acholeplasmatales;
OC   Acholeplasmataceae; Phytoplasma; 16SrI (Aster yellows group).
OX   NCBI_TaxID=262768 {ECO:0000313|EMBL:BAD04590.1, ECO:0000313|Proteomes:UP000002523};
RN   [1] {ECO:0000313|EMBL:BAD04590.1, ECO:0000313|Proteomes:UP000002523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OY-M {ECO:0000313|Proteomes:UP000002523};
RX   PubMed=14661021; DOI=10.1038/ng1277;
RA   Oshima K., Kakizawa S., Nishigawa H., Jung H.-Y., Wei W., Suzuki S.,
RA   Arashida R., Nakata D., Miyata S., Ugaki M., Namba S.;
RT   "Reductive evolution suggested from the complete genome sequence of a
RT   plant-pathogenic phytoplasma.";
RL   Nat. Genet. 36:27-29(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; AP006628; BAD04590.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6YQ70; -.
DR   STRING; 262768.PAM_505; -.
DR   KEGG; poy:PAM_505; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_011020_0_0_14; -.
DR   Proteomes; UP000002523; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          3..296
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         24..31
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   873 AA;  104591 MW;  69FAC372AE63B7A3 CRC64;
     MLFNLSKEQK DIINSDASCM YIHGGAGSGK TTILIEKLRQ KEKEKPLILV ATNATKNIIY
     DKLFSSLKED YPSYNDDELE KYLKDNYEIR TFHSFAYSCY LKYNIFNETA KQRKFIDDET
     KLNILKLILK ENQDLKLYFK EQRKYSFRKL LQELNNLIRL TFQKENCYSS IKIDDKVLKK
     SFELLLNLYY EKLNYYNLIT FDGLLIETSD FIEFVERNNG LIYNRLVFID EFQDLNYFYY
     FIIKELLFNK PNSLYCFGDY TQNIYSSFGS SERILELFVK DFKPEKHFLN VNYRSKGINI
     VKAANELIDN KEYLQLSFSE KKYRDFINFS FFDNFYQQIN YLCEKIKNSL ISSTTVLCRS
     NAELQKIKDE FTKNQILFTT SDNNSKENEI ILSTIHGYKG YENEYVYLIG WQNRNELQDK
     VLEKKLIYTA ITRAKRDIEI LTLNDSSIFI DYFYSLIKKE LISDDFTKGL NDKIFDLDYL
     KICLPNSKDI ENYDELSTTI KIYNEKVNQL EKQHKFNQIT ESYYKKCYLK LCVLFKEISK
     NIYKVNKKDN GYETRLKGFN YFMFEPLERI KCYKKYLKEK KEERHLSLSD DDLKLDYSLK
     KQLKENNFQE IKPKSKILRH YRDSSQNAKD KLLYNFKDSK KISFITLTAP YDDLQGKAIK
     YTHEPDIMGQ VRKRFIRLVR KNYLSNLFQQ FSQKDLVYSK MQDFRYFWSL ETTKLGVIHY
     HIIFNIDVLN SFGVYSRYLC TDKDYALGLK NRPIKGNKSI FYDDYLMHKI DEKGNIKIPQ
     NYYEKKNVKV PKITLLWANA YASVMNKNNI KHYKHLNPIS QNVQIFRPSK TNLLFEKIEI
     SKCKPFYKGT FDKKIMSIKL FHMLVNMFLK MIN
//