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Database: UniProt
Entry: Q6YRB1
LinkDB: Q6YRB1
Original site: Q6YRB1 
ID   KITH_ONYPE              Reviewed;         209 AA.
AC   Q6YRB1;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   16-JAN-2019, entry version 81.
DE   RecName: Full=Thymidine kinase {ECO:0000255|HAMAP-Rule:MF_00124};
DE            EC=2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124};
GN   Name=tdk {ECO:0000255|HAMAP-Rule:MF_00124}; OrderedLocusNames=PAM_104;
OS   Onion yellows phytoplasma (strain OY-M).
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales;
OC   Acholeplasmataceae; Candidatus Phytoplasma;
OC   Candidatus Phytoplasma asteris.
OX   NCBI_TaxID=262768;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OY-M;
RX   PubMed=14661021; DOI=10.1038/ng1277;
RA   Oshima K., Kakizawa S., Nishigawa H., Jung H.-Y., Wei W., Suzuki S.,
RA   Arashida R., Nakata D., Miyata S., Ugaki M., Namba S.;
RT   "Reductive evolution suggested from the complete genome sequence of a
RT   plant-pathogenic phytoplasma.";
RL   Nat. Genet. 36:27-29(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+);
CC         Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216;
CC         EC=2.7.1.21; Evidence={ECO:0000255|HAMAP-Rule:MF_00124};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00124}.
DR   EMBL; AP006628; BAD04189.1; -; Genomic_DNA.
DR   RefSeq; WP_011160479.1; NC_005303.2.
DR   ProteinModelPortal; Q6YRB1; -.
DR   SMR; Q6YRB1; -.
DR   STRING; 262768.PAM_104; -.
DR   EnsemblBacteria; BAD04189; BAD04189; PAM_104.
DR   KEGG; poy:PAM_104; -.
DR   eggNOG; ENOG4107T8J; Bacteria.
DR   eggNOG; COG1435; LUCA.
DR   HOGENOM; HOG000076390; -.
DR   KO; K00857; -.
DR   OMA; KEQFGWI; -.
DR   OrthoDB; 1279539at2; -.
DR   BioCyc; OYEL262768:G1G26-135-MONOMER; -.
DR   Proteomes; UP000002523; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase;
KW   Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN         1    209       Thymidine kinase.
FT                                /FTId=PRO_0000175001.
FT   NP_BIND      16     23       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   NP_BIND      90     93       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   ACT_SITE     91     91       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00124}.
SQ   SEQUENCE   209 AA;  23351 MW;  4C432E38F5AB8AA7 CRC64;
     MTQKEQGQGF IEVVCGPMFA GKTEALIQRS NQALQLNKKI LSFKPQIDDR YSVKEEIVSH
     NQNTIPAILI DKSKDILPFI TPEINVVIID EAQFLDNDIV AIVDYLANCN IEVIISGLEL
     DFCGKPFGPM PYLLAIADTV TKLTSICAIS GKKANRTQRL IDGKPAQSNE PVVLVGGKEY
     HEPRCRKHHC LADIDKTKIN WQNFTNQSK
//
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