GenomeNet

Database: UniProt
Entry: Q700K0
LinkDB: Q700K0
Original site: Q700K0 
ID   SSPO_RAT                Reviewed;        5141 AA.
AC   Q700K0;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 101.
DE   RecName: Full=SCO-spondin;
DE   Flags: Precursor;
GN   Name=Sspo;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Meiniel O.;
RT   "Conservation of mammalian SCO-spondin.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the modulation of neuronal aggregation. May
CC       be involved in developmental events during the formation of the
CC       central nervous system (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
DR   EMBL; AJ629845; CAF33425.1; -; mRNA.
DR   RefSeq; NP_001007017.1; NM_001007016.1.
DR   SMR; Q700K0; -.
DR   IntAct; Q700K0; 1.
DR   STRING; 10116.ENSRNOP00000037189; -.
DR   PaxDb; Q700K0; -.
DR   PRIDE; Q700K0; -.
DR   Ensembl; ENSRNOT00000035906; ENSRNOP00000037189; ENSRNOG00000025848.
DR   GeneID; 474348; -.
DR   KEGG; rno:474348; -.
DR   UCSC; RGD:1549716; rat.
DR   CTD; 23145; -.
DR   RGD; 1549716; Sspo.
DR   eggNOG; KOG1215; Eukaryota.
DR   eggNOG; KOG1216; Eukaryota.
DR   eggNOG; KOG3538; Eukaryota.
DR   eggNOG; KOG3611; Eukaryota.
DR   eggNOG; KOG4475; Eukaryota.
DR   eggNOG; ENOG410XNSK; LUCA.
DR   GeneTree; ENSGT00940000155829; -.
DR   HOGENOM; HOG000154433; -.
DR   InParanoid; Q700K0; -.
DR   OMA; MQTKNEL; -.
DR   OrthoDB; 12226at2759; -.
DR   PhylomeDB; Q700K0; -.
DR   TreeFam; TF344272; -.
DR   Reactome; R-RNO-5173214; O-glycosylation of TSR domain-containing proteins.
DR   PRO; PR:Q700K0; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000025848; Expressed in 5 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   CDD; cd00112; LDLa; 9.
DR   Gene3D; 2.20.100.10; -; 23.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 4.10.400.10; -; 9.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR030119; SCO-spondin.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339:SF358; PTHR11339:SF358; 2.
DR   Pfam; PF08742; C8; 3.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF00057; Ldl_recept_a; 8.
DR   Pfam; PF01826; TIL; 12.
DR   Pfam; PF00090; TSP_1; 22.
DR   Pfam; PF00093; VWC; 1.
DR   Pfam; PF00094; VWD; 3.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00832; C8; 3.
DR   SMART; SM00192; LDLa; 10.
DR   SMART; SM00209; TSP1; 25.
DR   SMART; SM00214; VWC; 5.
DR   SMART; SM00215; VWC_out; 9.
DR   SMART; SM00216; VWD; 3.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF57424; SSF57424; 10.
DR   SUPFAM; SSF57567; SSF57567; 15.
DR   SUPFAM; SSF82895; SSF82895; 25.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS01209; LDLRA_1; 8.
DR   PROSITE; PS50068; LDLRA_2; 10.
DR   PROSITE; PS50092; TSP1; 24.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 2.
DR   PROSITE; PS51233; VWFD; 3.
PE   2: Evidence at transcript level;
KW   Calcium; Cell adhesion; Complete proteome; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL        1     17       {ECO:0000255}.
FT   CHAIN        18   5141       SCO-spondin.
FT                                /FTId=PRO_0000245044.
FT   DOMAIN       18    102       EMI.
FT   DOMAIN      194    400       VWFD 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN      472    527       TIL 1. {ECO:0000255}.
FT   DOMAIN      566    776       VWFD 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN      830    883       TIL 2. {ECO:0000255}.
FT   DOMAIN     1018   1224       VWFD 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN     1280   1336       TIL 3. {ECO:0000255}.
FT   DOMAIN     1380   1417       LDL-receptor class A 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1420   1456       LDL-receptor class A 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1456   1492       LDL-receptor class A 3.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1496   1534       LDL-receptor class A 4.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1569   1605       LDL-receptor class A 5.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1607   1646       LDL-receptor class A 6.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1660   1700       LDL-receptor class A 7.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1699   1753       TSP type-1 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     1755   1970       TSP type-1 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     1829   1868       EGF-like 1.
FT   DOMAIN     1869   1895       EGF-like 2.
FT   DOMAIN     1970   2030       VWFC 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     2070   2226       F5/8 type C. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00081}.
FT   DOMAIN     2235   2271       LDL-receptor class A 8.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2391   2427       LDL-receptor class A 9.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2448   2484       LDL-receptor class A 10.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2485   2538       TSP type-1 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2540   2595       TSP type-1 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2618   2660       TIL 4. {ECO:0000255}.
FT   DOMAIN     2700   2754       TSP type-1 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2758   2813       TSP type-1 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2815   2868       TSP type-1 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2969   3024       TSP type-1 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3025   3068       TSP type-1 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3075   3127       TIL 5. {ECO:0000255}.
FT   DOMAIN     3168   3235       TSP type-1 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3237   3292       TSP type-1 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3300   3350       TIL 6. {ECO:0000255}.
FT   DOMAIN     3393   3455       TSP type-1 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3457   3512       TSP type-1 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3514   3570       TIL 7. {ECO:0000255}.
FT   DOMAIN     3630   3678       TSP type-1 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3806   3862       TSP type-1 15. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3876   3928       TSP type-1 16. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3942   3998       TSP type-1 17. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4000   4055       TSP type-1 18. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4058   4113       TIL 8. {ECO:0000255}.
FT   DOMAIN     4155   4208       TSP type-1 19. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4249   4304       TSP type-1 20. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4306   4362       TSP type-1 21. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4364   4418       TSP type-1 22. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4422   4477       TIL 9. {ECO:0000255}.
FT   DOMAIN     4608   4659       TSP type-1 23. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4673   4719       TIL 10. {ECO:0000255}.
FT   DOMAIN     4759   4812       TSP type-1 24. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4814   4868       TIL 11. {ECO:0000255}.
FT   DOMAIN     4920   4978       TIL 12. {ECO:0000255}.
FT   DOMAIN     4978   5036       VWFC 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     5047   5134       CTCK. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00039}.
FT   COMPBIAS    896    899       Poly-Thr.
FT   CARBOHYD     88     88       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    130    130       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    150    150       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    167    167       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    657    657       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    822    822       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    895    895       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    949    949       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    991    991       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1357   1357       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1655   1655       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1668   1668       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1725   1725       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1814   1814       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2035   2035       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2130   2130       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2148   2148       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2630   2630       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2679   2679       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2921   2921       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2951   2951       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3046   3046       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3101   3101       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3148   3148       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3158   3158       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3295   3295       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3384   3384       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3506   3506       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3584   3584       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3611   3611       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3787   3787       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3910   3910       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4135   4135       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4345   4345       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4416   4416       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4557   4557       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4727   4727       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4744   4744       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4749   4749       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4899   4899       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4942   4942       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4949   4949       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   5055   5055       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID   1381   1394       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1388   1407       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1401   1416       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1421   1433       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1428   1446       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1440   1455       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1457   1469       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1464   1482       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1476   1491       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1497   1509       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1504   1522       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1516   1533       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1570   1582       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1577   1595       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1589   1604       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1608   1621       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1615   1634       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1628   1645       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1661   1671       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1666   1684       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1678   1699       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1711   1747       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1715   1752       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1726   1737       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1767   1964       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1771   1969       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1781   1791       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2070   2226       {ECO:0000255|PROSITE-ProRule:PRU00081}.
FT   DISULFID   2236   2248       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2243   2261       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2255   2270       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2392   2404       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2399   2417       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2411   2426       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2449   2461       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2456   2474       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2468   2483       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2486   2522       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2497   2501       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2532   2537       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2552   2589       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2556   2594       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2567   2579       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2701   2739       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2712   2716       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2749   2753       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2769   2807       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2773   2812       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2789   2797       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2827   2862       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2831   2867       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2842   2852       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2970   3008       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2981   2985       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3018   3023       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3180   3229       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3184   3234       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3195   3219       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3249   3286       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3253   3291       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3264   3276       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3405   3448       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3409   3454       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3420   3432       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3469   3504       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3472   3511       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3482   3494       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3642   3672       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3646   3677       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3657   3662       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3818   3856       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3822   3861       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3834   3846       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3943   3979       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3954   3958       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3992   3997       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4012   4049       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4016   4054       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4027   4039       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4156   4192       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4167   4171       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4202   4207       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4261   4298       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4265   4303       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4276   4288       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4365   4402       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4376   4378       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4412   4417       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4609   4643       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4620   4624       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4653   4658       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4771   4806       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4775   4811       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4786   4795       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   5047   5095       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   DISULFID   5061   5112       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   DISULFID   5071   5128       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   DISULFID   5075   5130       {ECO:0000255|PROSITE-ProRule:PRU00039}.
SQ   SEQUENCE   5141 AA;  550649 MW;  1772AE67F02CA5E3 CRC64;
     MLLPALLFGM LWAPANGHWC EQIETVHVEE EVTPRREDLV PCTSLYHYSR LGWKLDLSWG
     GHVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG IHCTEALAEA SPKGHCFVTW
     HCQPLAGSAN SSAGSLEECC AQPWGHSWWN SSSQMCLSCS GQHRPGNASS EGLLQPLAGA
     VGQLWSQRQR PSATCATWSG FHYQTFDGQH YHFLGQCTYL LAGAMDSTWA VHLRPSVHCP
     QPRQCWLVQV IMGPEEVLIQ DGEVSVKGQP VPVGESQLLH GMSLQWQGDW LVLSGGLGVV
     VRLDRSSSII ISVDHEFWGR TQGLCGLYNG RPEDDFVEPG GGLAMLAATF GNSWRLPGYE
     PGCLDTVEVA RGCEGLLEGT LTGLEAGKLQ AQAQDLCHQL LEDPFSQCHG QVPPDEYHET
     CLFAYCVGAT AGSGPEEQVK AVCATFANYA QACARQHIYV HWRKPGFCER LCPGGQLYSD
     CISSCPPSCS AVAQGEEGSC GKECVSGCEC PTGLFWDGAL CVPAAHCPCY YRRQRYAPGD
     TVKQQCNPCV CQDGRWHCAQ APCPAECAVG GDGHYCTFDG RSFSFRGNPG CQYSLVQDSV
     KGQLLVVLEH GACETGSCLH ALSAFLGKTH IQLRYSGAVL VDGQDVDLPW IGAEGFNVSH
     ASSTFLLLRW PGAWVLWGVA DPAVYITLDP RHAYQVQGLC GTFTWKQQDD FLTPAGDIET
     SVTAFASKFQ VSGDGRCPLV DNTPLSSCST YSQRLAFAEA ACAALHGHAF QECHGLVERE
     PFRLRCLESM CSCAPGRDCL CSVLSAYAHH CAQEGVLLQW RNETLCSVPC PGGQVYQECA
     PACGHYCGEP EDCKELGSCV AGCNCPPGLL WDLEGQCVPP SMCPCQLGGH RYAFNTTTTL
     KDCSHCICQE RGLWNCIAHH CPRQWALCPQ ELIYAPGACL LTCDSLGANH SCLAGSTDGC
     VCPSGTVLLD KHCVSPDLCP CRHNGQWYPP NATIQEDCNI CVCQNQRWHC TGQRCSGWCQ
     ASGAPHYVTF DGLVFTFPGA CEYLLVREAG GRFSVSIQNL PCGASGLTCT KALAVRLDST
     VVHMLRGQAV TVNGVSIKLP KVYTGPGLSL HHAGLFLLLT TRLGLTLLWD GGTRVLVQLS
     PHFHGRVTGL CGNFDGDVSN DLRSRQGVLE PTAELTAHSW RLNPLCPEPG DLPHPCSVNA
     HRVNWARAHC EVILQPIFAP CHTEVPPQQY YEWCVYDACG CDTGGDCECL CSAIATYADE
     CARHRHHVRW RSQELCPLQC EGGQVYEPCG STCPPTCHDH HPELRWHCQA ITCVEGCFCP
     EGTLLHGGTC VELTDCPCEW QGSFFPPGAV LQKDCGNCTC QESQWHCNPS GAPCEEMEPG
     CAEGEALCRE SGHCVPLEWL CDNQDDCGDG SDEEGCDTSV CGEGQMSCQS GRCLPLSLIC
     DGQDDCGDGT DEQGCLCPQG FLACADGRCL PPALLCDGHP DCLDAADEES CLGWVSCTSG
     EVSCVDGPCI RTIQLCDGVW DCPDGADEGP VHCSSPSLPT PPAGIGQNPS TSSPDTSPSP
     VGSASPASPC SLSEFQCNSG ECTPRGWRCD REEDCTDGSD ELDCGGPCKL YQMPCAHGPH
     CLSPGQLCDG VAQCPDGSDE DPDVCEERSA SGGPNGTAVP CPEFSCPNGT CIDFLLVCDG
     SPDCELADET EPSLDEQGCG TWGSWGPWEP CSQTCGPGIQ SRNRNCSISS LHVLQNCPGL
     QHQSQSCFTE ACPVDGEWSS WSLWSPCSEP CGGTMTRHRQ CRPPQNGGQD CALLPGSTHS
     THQTSPCPQE GCLNVTCFGE LVFRPCAPCP LTCDDISGEA VCSPDRPCSS PGCWCPEGKV
     LGTEGRCVRP RQCPCLVDGI RYWPGQRIKM DCQLCFCQDG QPHRCRPNPE CAVDCGWSSW
     SPWAECLGPC SSQSLQWSFR SPNNPRLSGH GRQCRGIHRK ARRCQTEPCE GCEQWGLTYH
     VGERWRGGPC TVCECLHRSI TRCSPYCPIG SCPQSWVLVE GMGESCCHCA LPGKNQTMIP
     VTTPAPVPTP SPQIGASLVT YVLPPMSDAC YSPLGLAGLP TWAPSQPLEH STRAAPVEAP
     TAGPGPREDA YAEWHTQPLY LQLDLLWPRN LTGIMVQRAG SSAAYISNLS LQFSSDGLQW
     HSVLNSLSST LPPPKPSPES SNHMVPEVWT FDQMVQARYI RVWPHGSHLR DNNQQDIFLW
     VELLGCKPVP PLAPLCPGTR HRCANGDCAL KGGPCDGAVD CEDGSDEEGC GPLRASTASR
     VHSTARTPAL SPTQPGKFPF HPREGLADME HQQPKQESPM PSAGVSPSAS EGLLPVSGQS
     MQTLTTTSTF PPGLKSLHPG MAAVTVHSPH SVMPGTPVGQ SVSPRPFPLM RCGPGQVPCD
     VLGCVEQEQL CDGREDCLDG SDEQHCASPE PFTVPTTALP GLPASRALCS PSQLSCGSGE
     CLPLEHRCDL QVNCQDGSDE DDCVDCVLAP WSGWSDCSRS CGLGLIFQHR ELLRPPLPGG
     SCLLDQLRSQ PCFVQACPVA GAWAKWGPWE PCSVSCGGGH QSRQRSCVDP PPKNGGAPCP
     GPSHEKVLCN LQLCPGDTDC EPGRVHVNAE LCQKGLLPPC PPSCLDPEAN RSCSGHCVEG
     CRCPPGLFLQ DSHCLPLSEC PCLVGQKLMQ PGLAFLLDNC SQCICESGIL LCKPAACSQS
     CGWSAWSPWT ACDHSCGSGV RARFRSPTNP PAAFGGSPCE GDRQELQACY TDCGTDIPGW
     TPWTSWSSCS QSCLVPGGDP GRRQRSRLCP SSRDTFCPGE ATQEEPCSPS LCPVPSAWGL
     WASWSACSAS CNGGIQTRGR SCSGSAPGNP VCLGPHTQTR DCNVHPCTAQ CPGNMVFRSA
     EKCLEEGGPC PQLCLAQDPG VECTGSCAPG CSCPPGLFLH NASCLPRSQC PCQLHGQLYA
     PGAVARLDCN NCTCSSGEMV CTSERCPVAC GWSPWTPWSP CSQSCNVGIR RRFRAGTAPP
     AAFGGAECRG PNLDAEFCTL RPCQGPGAAW SSWTPCSVPC GGGYRNRTQG SGRHSPVEFS
     TCSLQPCAGP VPGVCPKDQQ WLDCAQGPAS CAHLSTPREA NQTCHPGCYC LSGMLLLNNV
     CVPAQDCPCA HRGRLHSPGS AVILPCENCS CVSGLITNCS SWPCEEGQPA WSSWTPWSVC
     SASCSPARRH RRRFCVRPST TAPFSLDLPT TVAAPTMLCP GPEAEEEPCL LPGCNQAGVW
     GPWSPWSGCS RSCGGGLRSR TRACDKPPPQ GLGDFCEGPQ AQGEACQAQP CPVANCSTIE
     GAEYSPCGPP CPRSCDDLVH CMWHCQPGCY CPPGKVLSAD GAICVQPHHC SCLDLLTGKR
     HHPGSQLMRP DGCNHCTCME GRLNCTDLPC QVSGDWCPWS EWTACSQPCR GQTRTRSRAC
     VCPAPQHGGA PCPEEAGETG VQHQMEACPN PTACPVDGAW SPWGSWSPCD ACLGQSYRSR
     MCSHPPPSDG GTPCLGGHQQ SRPCRNSSTP CTDCGGGQDL LPCGQPCPHS CQDLSLGSTC
     QPGSSGCQSG CGCPPGQLSQ DGLCVFPADC HCHFQPKAMG IPENQSRSVG SALSSWESLE
     PGEVVTGPCD NCTCVAGVLQ CHEVPSCPGP GIWSSWGPWE KCSVPCGGGE QLRSRQCARP
     PCPGLAQQSR TCHIHVCRET GCPAGRLYRE CQPSEGCPFS CAHVTGQVAC FSESCEEGCH
     CPEGTFQHHS ACVQECPCVL TVSLLQELGV ASTALRSYPV LLGDEGQPLG PGDELDPGQM
     LQTVCGNCSC VHGKLSCSME ECSRVRGYFG PWGMWSLCSH SCGGLGTRTR TRQCVLPTLA
     PAGLSCRGPL QDLEYCFSPE CPGTAGSTVE PVTGLAGGWG PWSPWSPCSH SCTDLTHPAW
     RSRTRLCLAN CTVGDSSQER PCNLPSCTTL PLCPGPGCGS ENCFWTSWAP WEPCSRSCGV
     GQQRRLRAYH PPGPGGHWCP DILTAYQERR FCNLRACPVP GGWSHWSPWS WCDRSCGGGR
     SLRSRSCSSP PPKNGGASCV GERHHVRSCN PMPCEKDCPA GMEMVSCANR CPYSCSDLQE
     AVMCQEDQAC QLGCRCSEGF LEQDGGCVPV GHCECTDAQG RSWAPGSQHQ DACNNCSCQA
     GQLSCTAQPC PPPAHCAWSH WSAWSACSHS CGPHGQQSRF RSSTSGSWAL ECQKEQSQSQ
     PCPEDPCPPL CLHEAHLHVL GDNWLHGECQ QCSCTPEGVI CKDTDCAVPG GWTLWSSWSY
     CSVSCGGGSQ VRTRSCMVSA PQHGSPSCQG PDTQTQHCGQ QLCLQLLEIC SWGPWGPCSR
     SCGTGLASRS GSCPCLLTKE DSECNDTFSG LDTQACYPGP CQEDCMWSDW SSWTRCSCKI
     LVQQRYRHQV PAPGQAGEGT LCTGLDGHFR PCAIGNCSED SCLPPFEFQS CGSPCAGLCA
     THLSHQLCQD LPPCQPGCYC PMGLLEQDGG CILPEQCNCW HTSGEGARVT LAPGHRLQLG
     CKECVCQSGE LQCSSQGCEG LLPLTGWSEW SPCGPCLPQS ALAPDSRTAL EVHWPLNTSV
     TLLASEQYRH RLCLDPETGR PWAGDPALCT VPLSQQRLCS DPGACHDTCQ WGPWGPWSPC
     QVPCSGGFKL RWREASDNSV GECRGPWAQT ESCNMGSCPG ESCETRDTVF TLDCANQCPR
     SCADLWEGVQ CLQGPCSPGC RCPPGQLVQD GHCVPISSCR CGLPSANASW ELAPTQVVQL
     DCHNCTCING TLMCPYPECP VLGPWSPWSE CSAVCGGGTM VRYRSCEEHP DSAPCQALDM
     EQRVECNLQT CPECPPGQVL STCATLCPSF CSHLWPGTIC VREPCQLGCG CPGGQLLHSG
     TCIPPEACPC TRLSLPWGLT LPLEEQAQEL PSGTVLTWNC THCTCQGGVF TCSHTDCQEC
     PPGEILQLGE LRPCEKTCLE MNKTQAWSNC TEAQVPGCVC QLGHFRSHTG LCVPEDHCEC
     WHHGSPHLPG SEWQEACESC RCLHGKSVCT QHCPELSCAQ GEVVVQEPGS CCPICQQDTL
     EEEPVSCRHL TELRNLTKGP CHLDQVEVSY CSGHCRSSTN VMTEEPYLQS QCDCCSYRLD
     PDSPVRILNL LCPDGRTEPV LLPVIHNCHC SACQGGEFSK H
//
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