ID Q70I20_ONCMY Unreviewed; 206 AA.
AC Q70I20;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Interleukin 17 isoform D {ECO:0000313|EMBL:CAE45584.1};
DE SubName: Full=Interleukin 17d {ECO:0000313|Ensembl:ENSOMYP00000058429.1};
GN Name=il-17D {ECO:0000313|EMBL:CAE45584.1};
GN Synonyms=il17d {ECO:0000313|Ensembl:ENSOMYP00000058429.1};
GN ORFNames=GSONMT00082076001 {ECO:0000313|EMBL:CDQ60595.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CAE45584.1};
RN [1] {ECO:0000313|EMBL:CAE45584.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Kidney head {ECO:0000313|EMBL:CAE45584.1};
RA Zou J., Secombes C.J.;
RT "Molecular cloning and expression analysis of interleukin 17 homologues in
RT rainbow trout, Oncorhynchus mykiss.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDQ60595.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [3] {ECO:0000313|EMBL:CDQ60595.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSOMYP00000058429.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the IL-17 family.
CC {ECO:0000256|ARBA:ARBA00007236}.
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DR EMBL; AJ580843; CAE45584.1; -; mRNA.
DR EMBL; FR904354; CDQ60595.1; -; Genomic_DNA.
DR RefSeq; NP_001117871.1; NM_001124399.1.
DR SMR; Q70I20; -.
DR STRING; 8022.Q70I20; -.
DR PaxDb; 8022-Q70I20; -.
DR Ensembl; ENSOMYT00000063598.2; ENSOMYP00000058429.1; ENSOMYG00000026987.2.
DR GeneID; 100136099; -.
DR KEGG; omy:100136099; -.
DR CTD; 53342; -.
DR GeneTree; ENSGT00940000161739; -.
DR OrthoDB; 4208634at2759; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR Proteomes; UP000694395; Chromosome 22.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020440; IL-17_chr.
DR InterPro; IPR010345; IL-17_fam.
DR Pfam; PF06083; IL17; 1.
DR PRINTS; PR01932; INTRLEUKIN17.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
PE 2: Evidence at transcript level;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..206
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007710105"
FT REGION 182..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 206 AA; 22880 MW; 82687037D6193AE8 CRC64;
MFGRVSFVCL LLVLLCDVAS VAKVSKKSTR GRKCLDLPEE ILEQMFGRLS VGVLSAFHHT
LQLAPLERKN LTCPSGGRPV PDRKSRIPVN LLSLSPWAYR ISHDPARYPR FIPEAYCLCK
GCLIGPFGQE SDQYRSTPVY MPSVILRRTG SCVGGRHSYT ESYVSVAVGC TCVPLLEKDR
DAQSSNQSLE REQTKADELS SNDKNI
//
