ID Q725Z0_DESVH Unreviewed; 543 AA.
AC Q725Z0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN OrderedLocusNames=DVU_3284 {ECO:0000313|EMBL:AAS97753.1};
OS Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM
OS B-1760 / Hildenborough).
OC Bacteria; Thermodesulfobacteriota; Desulfovibrionia; Desulfovibrionales;
OC Desulfovibrionaceae; Nitratidesulfovibrio.
OX NCBI_TaxID=882 {ECO:0000313|EMBL:AAS97753.1, ECO:0000313|Proteomes:UP000002194};
RN [1] {ECO:0000313|EMBL:AAS97753.1, ECO:0000313|Proteomes:UP000002194}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough
RC {ECO:0000313|Proteomes:UP000002194};
RX PubMed=15077118; DOI=10.1038/nbt959;
RA Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA Kolonay J.F., Eisen J.A., Ward N., Methe B., Brinkac L.M., Daugherty S.C.,
RA Deboy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C.,
RA Sullivan S.A., Fouts D., Haft D.H., Selengut J., Peterson J.D.,
RA Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M.,
RA Tran K., Khouri H., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D.,
RA Voordouw G., Fraser C.M.;
RT "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT Desulfovibrio vulgaris Hildenborough.";
RL Nat. Biotechnol. 22:554-559(2004).
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
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DR EMBL; AE017285; AAS97753.1; -; Genomic_DNA.
DR RefSeq; WP_010940541.1; NZ_CABHLV010000001.1.
DR RefSeq; YP_012493.1; NC_002937.3.
DR AlphaFoldDB; Q725Z0; -.
DR STRING; 882.DVU_3284; -.
DR PaxDb; 882-DVU_3284; -.
DR EnsemblBacteria; AAS97753; AAS97753; DVU_3284.
DR KEGG; dvu:DVU_3284; -.
DR PATRIC; fig|882.5.peg.2989; -.
DR eggNOG; COG1620; Bacteria.
DR HOGENOM; CLU_021628_0_0_7; -.
DR OrthoDB; 9761056at2; -.
DR PhylomeDB; Q725Z0; -.
DR Proteomes; UP000002194; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR NCBIfam; TIGR00795; lctP; 1.
DR PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU365092};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Reference proteome {ECO:0000313|Proteomes:UP000002194};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 40..59
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 71..94
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 115..134
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 154..178
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 222..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 247..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 296..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 397..418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 512..533
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
SQ SEQUENCE 543 AA; 57694 MW; 74F8BD94728A7773 CRC64;
MNWIQNYDPL SSALGSALVA AIPLFILFYM LAVKRAKGHV AAFLGTTSAI VLAIAVWGMP
VSLAASATLY GAAYGLFPIV WIVITAVWVY NMTVESGEFE IIKDSLARLT DDRRLQAIFI
AFAFGSFIEG TAGFGTPVAI TASMLVGLGF NPLYAAGICL IANTAPVAFG AIGIPIIVAG
QVTGLDTMHI SQIVGRQLPF LSVIVPMWLC VTMCGFKRAM EVLPAVAVAG VCFAGSQFVF
SNYHGPTLPD IMSAIVTIIG LVLLLRVWKP ATTWRFPGEA EVELSAVSQY SAGDVIRAWM
PYIILAVMVF FWGLDGVKKV LDGIFSVSVD WPGLHNLIEK TAPIAAKNAP YAAKYKLNLI
SAGGTAILLS GLLAVPVMPK YGFDKAIACL FRTFYQLRFP VVTIAMILGL AQIMNYSGMS
STLGIAFTKT GWLFPFFAPL LGWLGVFLTG SDTSSNALFG GMQRATAEAV GVDPHLTVAA
NSSGGVTGKM ISPQSISVAT ASTNMVGQEG SLFRFTLGHS IAMTLFVCVL TLLQAYPLKG
MLP
//
