ID Q73KU3_TREDE Unreviewed; 785 AA.
AC Q73KU3;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 118.
DE SubName: Full=ATP-dependent Clp protease, ATP-binding subunit ClpA {ECO:0000313|EMBL:AAS12644.1};
GN Name=clpA {ECO:0000313|EMBL:AAS12644.1};
GN OrderedLocusNames=TDE_2124 {ECO:0000313|EMBL:AAS12644.1};
OS Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS / KCTC 15104).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS12644.1, ECO:0000313|Proteomes:UP000008212};
RN [1] {ECO:0000313|EMBL:AAS12644.1, ECO:0000313|Proteomes:UP000008212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104
RC {ECO:0000313|Proteomes:UP000008212};
RX PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A., Daugherty S.C.,
RA Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.,
RA Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S.,
RA Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT "Comparison of the genome of the oral pathogen Treponema denticola with
RT other spirochete genomes.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
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DR EMBL; AE017226; AAS12644.1; -; Genomic_DNA.
DR RefSeq; NP_972725.1; NC_002967.9.
DR RefSeq; WP_002679937.1; NC_002967.9.
DR AlphaFoldDB; Q73KU3; -.
DR STRING; 243275.TDE_2124; -.
DR PaxDb; 243275-TDE_2124; -.
DR GeneID; 2739383; -.
DR KEGG; tde:TDE_2124; -.
DR PATRIC; fig|243275.7.peg.2007; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_4_2_12; -.
DR OMA; MSEECIG; -.
DR OrthoDB; 9803641at2; -.
DR Proteomes; UP000008212; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0043335; P:protein unfolding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR013461; ClpA.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02639; ClpA; 1.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF111; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPA; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:AAS12644.1};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Hydrolase {ECO:0000313|EMBL:AAS12644.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protease {ECO:0000313|EMBL:AAS12644.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 229..372
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 522..690
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 689..777
FT /note="Clp ATPase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01086"
FT REGION 158..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 87753 MW; F8C5685FA5904310 CRC64;
MNFTVSLTVR RIFQDAVEDA KKRNHEFVTP EHLLWAIMFN PKALELFTLS GSDLGYIHDN
LNTYLENKVP VRTQDNQAEP IQTVGLQNVF ERAILNCNAA EKPVIGINDI IVSLMDEEKN
HCSFFMKQSG IDRLRLLQLV SSPDFYDDGK NRSAYEEAED VQEAQGVKED SARHNSEEKN
TDKSKAQKTY LERFTVNLTE KARKGRLSPI IGREEEIERT IQILCRKQKN NPIHVGGAGV
GKTAITEGLA QRITANKVPS FLKNANIYSL SLSDLLAGAK FRGDFEERLK RIVSEISREK
NAILFIDEIH TIVNANSGGG GIEAPDLLKP ILANGKVRCI GATTFEEYNK HFTKDAALAR
RFQKIDIEEP NEEEAVKILK GLRESYENFH KVHYSDEVLE SAVHLSAIHI RDRFLPDKAI
DLIDEAGALI KIRADKEKNE NEADEKGLEE TALPEVSLSD IDKIVAKTAK IPEQRVSVNE
TEKLRHFEEI LSKKIFGQDT AIEGVTKAVK RSRAGFRSKD KPVANFLFVG PTGVGKTELA
KTLAEELGIP LLRFDMSEYQ EKHTVSRLIG SPPGYVGFEE GGLLTSAVQK SPNAVLLLDE
IEKAHADIYN ILLQIMDYAT LTDNQGRKAA FNNIILIMTS NAGSSNIGKP LIGFGGERIS
ESAVDEAVEK TFTPEFRNRL DAIIKFGPLT MQVMSLIIKK EVEKIRSQLA EKEISLELED
DVIPLLAEKG YSEEFGARNA ARLVEDEFVT PLTDMILFGE TKKGSSVKCQ IGDKLKKPYL
VLNIK
//