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Database: UniProt
Entry: Q73L03_TREDE
LinkDB: Q73L03_TREDE
Original site: Q73L03_TREDE 
ID   Q73L03_TREDE            Unreviewed;       944 AA.
AC   Q73L03;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 98.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   Name=feoB {ECO:0000313|EMBL:AAS12576.1};
GN   OrderedLocusNames=TDE_2063 {ECO:0000313|EMBL:AAS12576.1};
OS   Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222).
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
OX   NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS12576.1, ECO:0000313|Proteomes:UP000008212};
RN   [1] {ECO:0000313|EMBL:AAS12576.1, ECO:0000313|Proteomes:UP000008212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / CIP 103919 / DSM 14222
RC   {ECO:0000313|Proteomes:UP000008212};
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H.,
RA   Selengut J., Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A.,
RA   Daugherty S.C., Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K.,
RA   Tsegaye G., Malek J., Ayodeji B., Shatsman S., McLeod M.P., Smajs D.,
RA   Howell J.K., Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q.,
RA   Sodergren E., Baca E., Weinstock G.M., Norris S.J., Fraser C.M.,
RA   Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola
RT   with other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
CC       system. {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
CC       like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
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DR   EMBL; AE017226; AAS12576.1; -; Genomic_DNA.
DR   RefSeq; NP_972665.1; NC_002967.9.
DR   RefSeq; WP_002679857.1; NC_002967.9.
DR   STRING; 243275.TDE_2063; -.
DR   EnsemblBacteria; AAS12576; AAS12576; TDE_2063.
DR   GeneID; 2741190; -.
DR   KEGG; tde:TDE2063; -.
DR   PATRIC; fig|243275.7.peg.1947; -.
DR   eggNOG; ENOG4105CE1; Bacteria.
DR   eggNOG; COG0370; LUCA.
DR   KO; K04759; -.
DR   OrthoDB; 304844at2; -.
DR   BioCyc; TDEN243275:G1G0Q-2102-MONOMER; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008212};
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    296    322       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    328    347       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    368    390       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    425    454       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    481    500       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    512    537       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    543    564       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    602    621       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    887    906       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    918    938       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   DOMAIN        5    167       FeoB-type G. {ECO:0000259|PROSITE:
FT                                PS51711}.
SQ   SEQUENCE   944 AA;  105128 MW;  BA5462684DA4457E CRC64;
     MKKEKINIAF AGQPNSGKST LFNMMTGAHQ HVANYPGITV EKKTGEYFAL DQSVFITDLP
     GTYSLTSYSP EERVTRNFIL REKPELLVNI ADASNLERHL YLTFQLLEMN CPIVMYLNKM
     DSAKNAGLQI DVDKVSSLLG IPIIAGSAKK KEKINELKEL ISKTAESSEP QKPFMLTYGK
     DMESYLEKIV EKLKASAKDE FFSIPLRWLA IKLCEKDSAV IEEEGKNFTN FDSILTFIKE
     IEAEHKEKHK HSFEIEIALA RSAAAKKIVE AAVSKKELEQ KAVESLNIKR KVTETIAALI
     LCFVTYEILD SLFLLLPIPI VANNILRLIL SLAGAFAFTG GAALIYTKGG SGSINSTDRI
     DKVLCHKVYG LLILVELVLV FYWITVVLGY KMTDKVFPIF KFVRAIVSQL IYPEGLINEG
     PLRGLFLSGI IDGAIMILNY VPIFFCLFAL IAFLEDVGYM ARLAFIMDRI LRKFGLHGQS
     TLPMILSGVI MGGCVVPGVM STRTIRDDKS RLVTILILPL LNCMAKIPFY VLITGIFFTS
     YQWIVLGGIS FFTLIVALIV AKYFSLYVVH GKPEPFVLEL PAYNMPTLRG VLTRTFERLW
     SFIKKVATTV VAVSVIIWAG VNFPSLSSEK TAQYEARKAA YIQDFAGKLN NSYSQYFASE
     KGFIEYQRLT EKLYLYDAIN LFGGAKGMEK NINRLFLQNP EMTKIALKGK IELGSNIGAF
     KNYFDMYSSA KKDFDKAYND AQEFQKPILK ASFYAYWQKL NPYFFALVRT GKVKISGTAV
     IDSEAAAAAK AIRPASADLK LISVQLRKET LENSVLGYLG KAMEPVTKYA GFDWKVNIAI
     LGSFAAKEAL VSTLGTIYSV ESSSEDSGKV LEARIQDKET GLTPLDGLTI MILIALFPPC
     IATVMATKTE TQSVGWTLFS VMYPVVLSSL VAVLVFQLGR LFGF
//
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