ID Q73NB4_TREDE Unreviewed; 767 AA.
AC Q73NB4;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=HD domain protein {ECO:0000313|EMBL:AAS11759.1};
GN OrderedLocusNames=TDE_1241 {ECO:0000313|EMBL:AAS11759.1};
OS Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS / KCTC 15104).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS11759.1, ECO:0000313|Proteomes:UP000008212};
RN [1] {ECO:0000313|EMBL:AAS11759.1, ECO:0000313|Proteomes:UP000008212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104
RC {ECO:0000313|Proteomes:UP000008212};
RX PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A., Daugherty S.C.,
RA Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.,
RA Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S.,
RA Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT "Comparison of the genome of the oral pathogen Treponema denticola with
RT other spirochete genomes.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017226; AAS11759.1; -; Genomic_DNA.
DR RefSeq; NP_971848.1; NC_002967.9.
DR RefSeq; WP_002678734.1; NC_002967.9.
DR AlphaFoldDB; Q73NB4; -.
DR STRING; 243275.TDE_1241; -.
DR PaxDb; 243275-TDE_1241; -.
DR GeneID; 2741183; -.
DR KEGG; tde:TDE_1241; -.
DR PATRIC; fig|243275.7.peg.1193; -.
DR eggNOG; COG1480; Bacteria.
DR HOGENOM; CLU_015767_1_2_12; -.
DR OrthoDB; 9806952at2; -.
DR Proteomes; UP000008212; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR Pfam; PF07698; 7TM-7TMR_HD; 1.
DR Pfam; PF07697; 7TMR-HDED; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 528..669
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT REGION 731..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 85963 MW; BE885DC0D8797AE0 CRC64;
MIKNKKESKF KQKISFLSVI FKRNKAFVTA VAVSFLVLAV MIYLNAYENS GFSKLTISDF
EVGMVSDRDV ISNRNIEVID EKATEIRRVA AKHSVRAVFY KDDSVSEKMI REYSEFASYI
IGLKDSAKSF TAFKFMVMEK YPVLLSENDL ESIYKAVDFY EITSVSLNML KQLFDIGIIE
MPLTGLGELN DAEISLRTSQ DQKLSSTNVF LANLVLFYNV RDRIKTFLSD VKKSKLESYV
LSIVLPFAQP NILFDTEETE KRVDEALKKV TPVKINIEKN QKIIKRGFII SEDAYTRLKA
YAGDGRYIDF SQIAAALIFL TLSVIISLFL FSKKIIGESL DVKFNLLILI SFDLIYILIL
FLSRLSIFAY PLDIVPILPV TFLTMLIAAL ISRKISVFAV FVFSLAVFGA TGFKIQPAMF
AILSGLAGAG MVNIKGRRMD LIKTALGLIL VQPIILLCMF AIFPGSASEK SVLLLSTAGS
GFISGILVLG FLPILETLMN VPTSFRLMEL SDLNSPIMKK MLITVAGTYN HSMMVASLAE
SACREIGANS ILARVGAYYH DIGKMEQGEY FVENQTNYNK HMDINPRLSA TVIRSHVKIG
IEKAKQLRLP QPVIDIISEH HGNSCISYFY AKAKELDPNV DIEDFCYPGI PPRSKESAVV
MLADIVEAAC RTLEKPSVPR LEKFIDELVS GKIKSGQLDN SELTFREVRI IKAAFVKILA
GYYHSRIEYP NQKNVDDDEG TKPQNKNGQK LEVEASQVQP QKENHNV
//
