ID Q73TT2_MYCPA Unreviewed; 866 AA.
AC Q73TT2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=4Fe-4S Mo/W bis-MGD-type domain-containing protein {ECO:0000259|PROSITE:PS51669};
GN OrderedLocusNames=MAP_3636 {ECO:0000313|EMBL:AAS06186.1};
OS Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS (Mycobacterium paratuberculosis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316 {ECO:0000313|EMBL:AAS06186.1, ECO:0000313|Proteomes:UP000000580};
RN [1] {ECO:0000313|EMBL:AAS06186.1, ECO:0000313|Proteomes:UP000000580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10 {ECO:0000313|Proteomes:UP000000580};
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AE016958; AAS06186.1; -; Genomic_DNA.
DR AlphaFoldDB; Q73TT2; -.
DR STRING; 262316.MAP_3636; -.
DR KEGG; mpa:MAP_3636; -.
DR eggNOG; COG0243; Bacteria.
DR HOGENOM; CLU_000422_13_3_11; -.
DR Proteomes; UP000000580; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR Gene3D; 3.30.2070.10; Formate dehydrogenase/DMSO reductase; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR PANTHER; PTHR43105:SF14; POSSIBLE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000580}.
FT DOMAIN 3..59
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 866 AA; 92989 MW; E7F1816EC6CD199E CRC64;
MTGEWQPSAC ILCECNCGIV VQVEDRRLAR IRGDKAHPAS QGYTCNKALR LDHYQNSRAR
LTSPLRRRPD GSYEEIDWDT AIVEIAEGFK RIRDSYGGDK IFYYGGGGQG NHLGGAYSGA
FLKALGSRYR SNALAQEKTG ESWIDGQLYG GHTRGEFEHA EVAVFVGKNP WMSQSFPRAR
VVLNEIAKDP ARSMIVIDPV VTDTAKMADF HLRVRPGTDA WCLAALAAVL VQENLCDEAF
LAEHVRGADG VRRALRDVAV CECAAHCGVD EELLRTAARR IGTADSVAVF EDLGVQQAPN
STLCSYLNKL LWILTGNFAK RGGQHLHSSF APLFGQFSGR TPVTGAPIIS GLVPSNVVPE
EILTDHPDRF RAMIVESSNP AHSLANSAAC REAFASLELM VVIDVAMTET ARLAHYVLPA
ASQFEKPEAT FFNLEFPRNT FQLRRPLLTP LPGTLPEPEI WARLVRALGV VTEADLRPLH
DAARRGRHAY TEAFLTAVST NPTVAQLLPF VLYETLGPTL PDGLRGAAAL WGLAQKTALT
YREAVRRAGH ADGNALFDAI LDNPSGVTFT VHDYADDFTL IGHPDHKIAL EIPAMLQELA
KLSSGPPRLT TEEFPIVLSV GERRAYTAND IFRDPSWRKR DAEGALRVSV EDAQALGLAD
GCRARISTAA GSAEATVEIS ETMLAGHAAL PNGFGLDYIG DDGRTVVPGV APNAQPHVAG
HLGALVGLQV GAGTLEYLPQ RLGDAIGPGA VEHLFDLARG APVGVALQRA GDALPGGDVT
ALQSRTDGGG RPEFHRLVEV RQRGGRAAAA VALVPRGRPV RRRSRASVGC QRHLASSSIA
TATARQRCLI CSQSAGASAS GPWSSG
//
