ID Q73UI4_MYCPA Unreviewed; 726 AA.
AC Q73UI4;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE SubName: Full=CtpC {ECO:0000313|EMBL:AAS05934.1};
GN Name=ctpC {ECO:0000313|EMBL:AAS05934.1};
GN OrderedLocusNames=MAP_3384 {ECO:0000313|EMBL:AAS05934.1};
OS Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS (Mycobacterium paratuberculosis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316 {ECO:0000313|EMBL:AAS05934.1, ECO:0000313|Proteomes:UP000000580};
RN [1] {ECO:0000313|EMBL:AAS05934.1, ECO:0000313|Proteomes:UP000000580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10 {ECO:0000313|Proteomes:UP000000580};
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
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DR EMBL; AE016958; AAS05934.1; -; Genomic_DNA.
DR RefSeq; WP_010949941.1; NZ_CP106873.1.
DR AlphaFoldDB; Q73UI4; -.
DR STRING; 262316.MAP_3384; -.
DR KEGG; mpa:MAP_3384; -.
DR PATRIC; fig|262316.17.peg.3597; -.
DR eggNOG; COG2217; Bacteria.
DR HOGENOM; CLU_001771_0_3_11; -.
DR Proteomes; UP000000580; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd02079; P-type_ATPase_HM; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000000580};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 28..95
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 726 AA; 77294 MW; 48351DF3D0E61C1F CRC64;
MNLASVRAIG DEGLTKDPAL QVMSDAAGRM RVSVGWVRAD SRRAVAVEEA VAKCDGVRVV
HAYPRTGSVV IWYSPRRCDR SAVLAAIGEA AHVTAELIPA RAPHSSEIRN ADVLRMVIGG
AALALLGVRR YVFARPPLLG PSGRLFATGV TVFTGYPFLR GALRSLRSGR AGTDALVSAA
TVASLVLREN VVALTVLWLL NIGEYLQDLT LRRTRRAISE LLRGSQDTAW IRLEHNEIQV
ATDTLQIGDE VVVHDHVAIP VDGEVIDGEA IVDQSAITGE NLPVSVVVGM PVHAGSVVVR
GRLVVRARAV GNQTTIGRII TRVEEAQHDR APIQTVGENF SRRFVPTSFI VSAITLAVTG
DVRRAMTMLL IACPCAVGLA TPTAISAAIG NGARRGILIK GGSHLEQAGQ VDAIVFDKTG
TLTVGRPVVT NIVAMHKDWE PEQVLAYAAS SEIHSRHPLA EAVIRSTEER HITIPPHEEC
EVLVGLGMRT WADGRTLLLG SPSLLQAEKV KVSKKAKEWV DKLRRQAETP LLLAVDGTLV
GLISLRDEVR PEAAGVLKKL RANGIRRIVM LTGDHPDIAA VVADELGIDE WRAEVMPEDK
LAAVRDLQEE GFVVGMVGDG INDAPALAAA DIGIAMGLAG TDVAVETADV ALSNDDLHRL
LDVRDLGSRA VDVIRENYGM SIAVNAAGLI IGAGGALSPV LAAILHNASS VAVVANSSRL
IRYRLN
//
