ID Q73XH7_MYCPA Unreviewed; 3092 AA.
AC Q73XH7;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE SubName: Full=Fas {ECO:0000313|EMBL:AAS04649.1};
GN Name=fas {ECO:0000313|EMBL:AAS04649.1};
GN OrderedLocusNames=MAP_2332c {ECO:0000313|EMBL:AAS04649.1};
OS Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS (Mycobacterium paratuberculosis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316 {ECO:0000313|EMBL:AAS04649.1, ECO:0000313|Proteomes:UP000000580};
RN [1] {ECO:0000313|EMBL:AAS04649.1, ECO:0000313|Proteomes:UP000000580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10 {ECO:0000313|Proteomes:UP000000580};
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
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DR EMBL; AE016958; AAS04649.1; -; Genomic_DNA.
DR RefSeq; WP_010949565.1; NZ_CP106873.1.
DR SMR; Q73XH7; -.
DR STRING; 262316.MAP_2332c; -.
DR KEGG; mpa:MAP_2332c; -.
DR PATRIC; fig|262316.17.peg.2482; -.
DR eggNOG; COG0304; Bacteria.
DR eggNOG; COG0331; Bacteria.
DR eggNOG; COG2030; Bacteria.
DR eggNOG; COG4981; Bacteria.
DR HOGENOM; CLU_000114_7_0_11; -.
DR Proteomes; UP000000580; Chromosome.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd03447; FAS_MaoC; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.30.70.3320; -; 1.
DR Gene3D; 3.30.70.3330; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR041550; FASI_helical.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF18314; FAS_I_H; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF16073; SAT; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000580}.
FT DOMAIN 2555..3010
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1742..1789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2414..2439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3092 AA; 328074 MW; 3616EDD7DF0350D9 CRC64;
MTIHEHDRVS ADRDGQGPHG VKHPPAGDTH ALVDRLAAGE PYAVAFGGQG SAWLETLEEL
VSSAGIEPEL ATLVGEVDLL LEPVAKELVV VRPIGFEPLS WVRALAAEDP VPSNKHLTSA
AVSIPGVLLT QIAAVRALAR QGMDLTATPP VAVAGHSQGV LAVEALKGAG ARDVELLALA
QLIGAAGTLV ARRRGISVLG DRPPMVSVTN ADPERISRLL DEFAQDVRTV LPPVLSIRNG
RRSVVITGTP EQLSRFELYC RQISEKEEAE RKNKLRGGDV FAPVFDPVQV EVGFHTPRLA
DGIDIVGGWA EKVGLDVALA RELTEAILVR RVDWVQEITR VHESGARWIL DLGPGDILTR
LTAPVIRGLG VGIVPAATRG GQRNLFTVGA VPEVARAWSS YAPTLVRLPD GRVKLSTKFT
RLTGRSPILL AGMTPTTVDA KIVAAAANAG HWAELAGGGQ VTEEIFAARI EELSGLLEEG
RTYQFNALFL DPYLWKLQVG GKRLVQKARQ SGAAIDGLVI SAGIPELEEA VELIEELGDV
GISNVVFKPG TVEQIRSVIR IATEVSTKPV IVHIEGGRAG GHHSWEDLDD LLLATYSELR
SRPNITVCVG GGIGTPERAA EYLSGRWAEK YGFPLMPIDG ILVGTAAMAT LESTTSPSVK
RMLVETQGTE HWIGAGKAVG GMASSRSQLG ADIHEIDNSA SRCGRLLDEV AGDAEAVAER
RDEIIAAMAK TAKPYFGDVG EMTYLQWLQR YVELAIGDGD STADTASPGS PWLADTWRDR
FEQMLQRAEA RLHAKDFGPI ETLFDGSTED GARLLENPAE AIATLLAHYP DAESVQLHPA
DVPFFVTLCK TPGKPVNFVP VIDKDVRRWW RSDSLWQAHD ARYDADQVCI IPGTAAVAGI
TRMDEPVGEL LDRFEQAAID QALAAGVQPA AVTSRRTGRA DVTGPLAVVL DAPDVQWAGR
TAINPVHRIA EPGDWLVHDG PDSRRATHSS TGARLQVEGD RVVLSVPVSG TWVEIPFTLP
PNTIDGGTPV VSTDDAATAM RAVLAIAAGV DGPEFLPKVV DGAATVTVDW DPERVADHTG
VTATFGEPLA PSLTTVPDAL VGLCWPAVFA AIGAAATDTG VPVVEGLLSL VHLDHAAHMV
GKLPTTLAQL TVTATASAAA DTDMGRVVPV SVTIADAGGQ VIATLDERFA ILGRTGPAEL
TDPARAGGAV SENATDTPRR RRRDVTITAP VDMRPFAVVS GDHNPIHTDR AAALLAGLET
PIVHGMWLSA AAQHAVTATD GQARPPARLI GWTARFLGMV RPGDEVAFRV DRVGIDQGAE
VLEVAARVGS DLVMSATARL AAPRTVYAFP GQGIQHKGMG MDVRARSKAA RKVWDKADKF
TRDTLGFSVL RVVRDNPTSI IASGVHYNHP EGVLYLTQFT QVAMATVAAA QVAEMREQGA
FVEDAIACGH SVGEYTALAC VTGIYELEAL LETVFHRGSK MHDIVPRDEL GRSNYRLAAI
RPSQIDLPDD EVPAFVAGIA ERTGEFLEIV NFNLRGSQYA IAGTVRGLEA LEEEVERRRE
ITGGKRSFIL VPGIDVPFHS RVLRVGVAEF RRSLDRVMPR DKDPDIIIGR YIPNLVPRPF
TLDRDFIQEI RDLVPAEPLD PILADYDTWL AERRIEMART VLIELLAWQF ASPVRWIETQ
DLLFTEEAAG GLGVERFVEI GVKSAPTVAG LATNTLKLPE YAHSTVEVLN AERDAAVLFA
TDTDPEPEPE ADEASDSAVP ASSDGAPMSD VAPAPAAAPS GAPRPEDIPF DAADATLALI
ALSAKMRIDQ IEELDSIESI TDGASSRRNQ LLVDLGSELN LGAIDGAAEA DLAGLRAQVT
KLARTYKPYG PVLSDAINDQ LRTVLGPSGK RPGAIAERVK KTWDLGEGWA KHVTVEVALG
TREGTSVRGG ALGHLHEGAL ADAAAVDKAI DAAVAAVAAR RGITVALPSA GGGGAGATID
AAALGEFTEQ ITGRDGVLAS AARLVLNQLG LDEPAGAAAA SAATDAELID LVTAELGADW
PRLVAPVFDP KKAVLFDDRW ASAREDLVKL WLADEGDIDS QWLHLSERFE GAGHVVATQA
TWWQGKALSA GRAVHASLYG RIAAGAENPD PGRYSHEVAV VTGASKGSIA ASVVARLLDG
GATVIATTSK LDDERLAFYR GLYRDHARYG AALWVVAANM ASYSDIDALV EWIGTEQTES
LGPQSIHIKD AQTPTLLFPF AAPRVAGDLS EAGSRSEMEM KVLLWAVQRL IGGLSKIGAE
RDIASRLHVV LPGSPNRGMF GGDGAYGEAK SALDALVSRW HAESSWAARV SLAHALIGWT
RGTGLMGHND AIVDAVEQAG VTTYSTDEMA AMLLDLCDVE SKVAAASAPI KADLTGGLGE
VDLDMAELAA KAREQATGAE PAADDGPTAG TIAALPSPPR GFTPAPPPEW ADLDVDPADL
VVIVGGAELG PYGSSRTRFE MEVDNELSAA GVLELAWTTG LIRWEDDPQP GWYDTESGEL
VDESELVERY HDTVVARCGI REFVDDGAID PDHASPLLVS VFLDKDFTFV VSSEADARAF
VEFDPEHTII RPVPDSSDWQ VTRKAGTEIR VPRKTKLSRV VGGQLPTGFD PTVWGISPDM
ASSIDRVAVW NIVATVDAFL SAGFSPAEVM RYVHPSLVAN TMGTGMGGGT SMQTLYHGNL
LGRNKPNDIF QEILPNIVAA HVVQSYIGSY GAMIHPVAAC ATAAVSVEEG VDKIRLGKAE
MVVAGGIDDL TLEGIIGFGD MAATADTGMM RGRGISDAKF SRPNDRRRLG FVEAQGGGTI
LLARGDLALK MGLPVLAVVA YAQSFADGVH TSIPAPGLGA LGAGRGGKDS PLARALAKLG
VGADDVAVIS KHDTSTLAND PNETELHERL ADSLGRSEGA PLFVVSQKSL TGHAKGGAAV
FQMMGLCQML RDGVIPPNRS LDCVDDELAG SAHFVWVRET LRLGDKFPLK AGMVTSLGFG
HVSGLVALVH PQAFLAALDP EQRADYQQRA NARLLAGQRR LVSAIAGGAP MYQRPPDRRF
DHDVPEKRQE AAMLLDPASR LGDGDAYQVS AG
//
