ID Q74AD5_GEOSL Unreviewed; 248 AA.
AC Q74AD5;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=SAM-dependent methyltransferase {ECO:0000313|EMBL:AAR35814.1};
GN OrderedLocusNames=GSU2441 {ECO:0000313|EMBL:AAR35814.1};
OS Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geobacter.
OX NCBI_TaxID=243231 {ECO:0000313|EMBL:AAR35814.1, ECO:0000313|Proteomes:UP000000577};
RN [1] {ECO:0000313|EMBL:AAR35814.1, ECO:0000313|Proteomes:UP000000577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51573 / DSM 12127 / PCA
RC {ECO:0000313|Proteomes:UP000000577};
RX PubMed=14671304; DOI=10.1126/science.1088727;
RA Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.,
RA Heidelberg J.F., Wu D., Wu M., Ward N., Beanan M.J., Dodson R.J.,
RA Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.,
RA Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M.,
RA Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.,
RA Khouri H., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R.,
RA Fraser C.M.;
RT "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT environments.";
RL Science 302:1967-1969(2003).
RN [2] {ECO:0007829|PDB:5BP7}
RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 2-248 IN COMPLEX WITH
RP S-ADENOSYL-L-HOMOCYSTEINE.
RA Kutner J., Shabalin I.G., Mason D., Handing K.B., Gasiorowska O.A.,
RA Bonanno J., Seidel R., Almo S.C., Minor W.;
RT "Crystal structure of SAM-dependent methyltransferase from Geobacter
RT sulfurreducens in complex with S-Adenosyl-L-homocysteine.";
RL Submitted (MAY-2015) to the PDB data bank.
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DR EMBL; AE017180; AAR35814.1; -; Genomic_DNA.
DR RefSeq; NP_953487.1; NC_002939.5.
DR RefSeq; WP_010943078.1; NC_002939.5.
DR PDB; 5BP7; X-ray; 2.10 A; A/B/C=2-248.
DR PDBsum; 5BP7; -.
DR AlphaFoldDB; Q74AD5; -.
DR SMR; Q74AD5; -.
DR STRING; 243231.GSU2441; -.
DR EnsemblBacteria; AAR35814; AAR35814; GSU2441.
DR KEGG; gsu:GSU2441; -.
DR PATRIC; fig|243231.5.peg.2469; -.
DR eggNOG; COG2519; Bacteria.
DR HOGENOM; CLU_037315_0_0_7; -.
DR InParanoid; Q74AD5; -.
DR OrthoDB; 9792690at2; -.
DR Proteomes; UP000000577; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IBA:GO_Central.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR017031; Pre_MeTrfase_YjhP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43464; METHYLTRANSFERASE; 1.
DR PANTHER; PTHR43464:SF3; SAM-DEPENDENT METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR PIRSF; PIRSF034653; Mtase_yjhp_prd; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5BP7};
KW Methyltransferase {ECO:0000313|EMBL:AAR35814.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000577};
KW Transferase {ECO:0000313|EMBL:AAR35814.1}.
FT DOMAIN 35..146
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13847"
FT BINDING 17
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:5BP7"
FT BINDING 18
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:5BP7"
FT BINDING 66
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:5BP7"
FT BINDING 94
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:5BP7"
FT BINDING 95
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:5BP7"
FT BINDING 114
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:5BP7"
SQ SEQUENCE 248 AA; 27096 MW; 4C42DD8A3B16D092 CRC64;
MDIPRIFTIT ESAHRIHNPI TPEKLTTLGA ALRLEPGTRV LDLGSGSGEM LCTWARDHGI
IGTGIDMSQL FTAQAKLRAE ELGVADRVTF IHGDASGYVS DDKAGVAACV GATWIGGGVA
GTIELLARSL RPGGIILIGE PYWRQVPPTE DVARGCLANS TSDFLMLPEL LASFGRLGYD
VVEMVLADQD GWDRYEAAKW LTMRRWLEAN PDDELAKEVR AQLTSEPGRY ASYTREYLGW
GVFALMPR
//
