ID Q74EY7_GEOSL Unreviewed; 729 AA.
AC Q74EY7;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 13-SEP-2023, entry version 135.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=GSU0822 {ECO:0000313|EMBL:AAR34152.1};
OS Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geobacter.
OX NCBI_TaxID=243231 {ECO:0000313|EMBL:AAR34152.1, ECO:0000313|Proteomes:UP000000577};
RN [1] {ECO:0000313|EMBL:AAR34152.1, ECO:0000313|Proteomes:UP000000577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51573 / DSM 12127 / PCA
RC {ECO:0000313|Proteomes:UP000000577};
RX PubMed=14671304; DOI=10.1126/science.1088727;
RA Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.,
RA Heidelberg J.F., Wu D., Wu M., Ward N., Beanan M.J., Dodson R.J.,
RA Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.,
RA Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M.,
RA Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.,
RA Khouri H., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R.,
RA Fraser C.M.;
RT "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT environments.";
RL Science 302:1967-1969(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; AE017180; AAR34152.1; -; Genomic_DNA.
DR RefSeq; NP_951879.1; NC_002939.5.
DR RefSeq; WP_010941489.1; NC_002939.5.
DR AlphaFoldDB; Q74EY7; -.
DR SMR; Q74EY7; -.
DR STRING; 243231.GSU0822; -.
DR EnsemblBacteria; AAR34152; AAR34152; GSU0822.
DR KEGG; gsu:GSU0822; -.
DR PATRIC; fig|243231.5.peg.820; -.
DR eggNOG; COG2770; Bacteria.
DR eggNOG; COG4251; Bacteria.
DR HOGENOM; CLU_000445_114_71_7; -.
DR InParanoid; Q74EY7; -.
DR OMA; ARGWYKA; -.
DR OrthoDB; 5341439at2; -.
DR Proteomes; UP000000577; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0007234; P:osmosensory signaling via phosphorelay pathway; IBA:GO_Central.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR CDD; cd12914; PDC1_DGC_like; 1.
DR CDD; cd18774; PDC2_HK_sensor; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR42878:SF7; OSMOLARITY TWO-COMPONENT SYSTEM PROTEIN SSK1; 1.
DR PANTHER; PTHR42878; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAR34152.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000577};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 305..358
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 363..433
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 437..489
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 518..729
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 480..511
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 729 AA; 80786 MW; 5E061C5912A1FF45 CRC64;
MKLRTKLIIL VSILVIILMV VTSRITLGYL ERHLHDSIAA QQTATVVHVA TDIDSTLRSM
LELLTASARV VPPAALADPS GAKAFLESRT GLRTLFNNHL FVVDAAGNLL AEVTNQEVRR
VENFSGHAFF NKARATRKPL ISELTTCCTG TANLREIVFI SPILGKNGSF KGALLGGIDL
SEENALSRFG RITVGNKGFI RIIDRNHMVL IHAEREHTLI KAVPEVARLA DAAREGYVGT
RETKGRYGDI LLTSVAKLGS KDWVVAASYP LTVAYEPVKV VRRLFIISTV VAILGVLVVV
SLSMQYLTRP ILALERHINE LSGKKGKERL VPVSNEDELS RLTETFNTML AEIDRQTESL
RESEDRFRGA FEQAAVGMAI IDREGLLLRT NRRFCDITGR HDEDLAGLDC LTLVHPEDRN
ATREIMPTMA ATEGEPLTRE LRFTHGTGRT VWANTAFSPV RGRSGTDDSF IMVVEDVTER
KRAEEEILRL NSDLEQRVAD RTAALESANR ELEAFSYTVS HDLKAPARHI SGIVDIVLED
WGGCMEPAHR ELMERVAAAA GRMQSMIDGL LELSRVGSDE LRRQEVRPAH LAREICIELA
AAEPARQVDW SVKDVPPANA DPELLMTVLE NLLGNAWKYT SRNERAEVEF GCEYCSGKNM
YYVKDNGAGF DIREAQRLFA PFQRFHPASE FEGNGIGLAT VARIIHRHGG TIRAESAPGR
GATFYFSLD
//