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Database: UniProt
Entry: Q74EY7_GEOSL
LinkDB: Q74EY7_GEOSL
Original site: Q74EY7_GEOSL 
ID   Q74EY7_GEOSL            Unreviewed;       729 AA.
AC   Q74EY7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   13-SEP-2023, entry version 135.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   OrderedLocusNames=GSU0822 {ECO:0000313|EMBL:AAR34152.1};
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231 {ECO:0000313|EMBL:AAR34152.1, ECO:0000313|Proteomes:UP000000577};
RN   [1] {ECO:0000313|EMBL:AAR34152.1, ECO:0000313|Proteomes:UP000000577}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA
RC   {ECO:0000313|Proteomes:UP000000577};
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.,
RA   Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M.,
RA   Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.,
RA   Khouri H., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R.,
RA   Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; AE017180; AAR34152.1; -; Genomic_DNA.
DR   RefSeq; NP_951879.1; NC_002939.5.
DR   RefSeq; WP_010941489.1; NC_002939.5.
DR   AlphaFoldDB; Q74EY7; -.
DR   SMR; Q74EY7; -.
DR   STRING; 243231.GSU0822; -.
DR   EnsemblBacteria; AAR34152; AAR34152; GSU0822.
DR   KEGG; gsu:GSU0822; -.
DR   PATRIC; fig|243231.5.peg.820; -.
DR   eggNOG; COG2770; Bacteria.
DR   eggNOG; COG4251; Bacteria.
DR   HOGENOM; CLU_000445_114_71_7; -.
DR   InParanoid; Q74EY7; -.
DR   OMA; ARGWYKA; -.
DR   OrthoDB; 5341439at2; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR   GO; GO:0007234; P:osmosensory signaling via phosphorelay pathway; IBA:GO_Central.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00130; PAS; 1.
DR   CDD; cd12914; PDC1_DGC_like; 1.
DR   CDD; cd18774; PDC2_HK_sensor; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR42878:SF7; OSMOLARITY TWO-COMPONENT SYSTEM PROTEIN SSK1; 1.
DR   PANTHER; PTHR42878; TWO-COMPONENT HISTIDINE KINASE; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAR34152.1};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000577};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          305..358
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          363..433
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          437..489
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          518..729
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   COILED          480..511
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   729 AA;  80786 MW;  5E061C5912A1FF45 CRC64;
     MKLRTKLIIL VSILVIILMV VTSRITLGYL ERHLHDSIAA QQTATVVHVA TDIDSTLRSM
     LELLTASARV VPPAALADPS GAKAFLESRT GLRTLFNNHL FVVDAAGNLL AEVTNQEVRR
     VENFSGHAFF NKARATRKPL ISELTTCCTG TANLREIVFI SPILGKNGSF KGALLGGIDL
     SEENALSRFG RITVGNKGFI RIIDRNHMVL IHAEREHTLI KAVPEVARLA DAAREGYVGT
     RETKGRYGDI LLTSVAKLGS KDWVVAASYP LTVAYEPVKV VRRLFIISTV VAILGVLVVV
     SLSMQYLTRP ILALERHINE LSGKKGKERL VPVSNEDELS RLTETFNTML AEIDRQTESL
     RESEDRFRGA FEQAAVGMAI IDREGLLLRT NRRFCDITGR HDEDLAGLDC LTLVHPEDRN
     ATREIMPTMA ATEGEPLTRE LRFTHGTGRT VWANTAFSPV RGRSGTDDSF IMVVEDVTER
     KRAEEEILRL NSDLEQRVAD RTAALESANR ELEAFSYTVS HDLKAPARHI SGIVDIVLED
     WGGCMEPAHR ELMERVAAAA GRMQSMIDGL LELSRVGSDE LRRQEVRPAH LAREICIELA
     AAEPARQVDW SVKDVPPANA DPELLMTVLE NLLGNAWKYT SRNERAEVEF GCEYCSGKNM
     YYVKDNGAGF DIREAQRLFA PFQRFHPASE FEGNGIGLAT VARIIHRHGG TIRAESAPGR
     GATFYFSLD
//
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