ID Q74GA2_GEOSL Unreviewed; 826 AA.
AC Q74GA2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=NADH dehydrogenase I, G subunit {ECO:0000313|EMBL:AAR33677.1};
GN Name=nuoG-1 {ECO:0000313|EMBL:AAR33677.1};
GN OrderedLocusNames=GSU0344 {ECO:0000313|EMBL:AAR33677.1};
OS Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geobacter.
OX NCBI_TaxID=243231 {ECO:0000313|EMBL:AAR33677.1, ECO:0000313|Proteomes:UP000000577};
RN [1] {ECO:0000313|EMBL:AAR33677.1, ECO:0000313|Proteomes:UP000000577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51573 / DSM 12127 / PCA
RC {ECO:0000313|Proteomes:UP000000577};
RX PubMed=14671304; DOI=10.1126/science.1088727;
RA Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.,
RA Heidelberg J.F., Wu D., Wu M., Ward N., Beanan M.J., Dodson R.J.,
RA Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.,
RA Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M.,
RA Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.,
RA Khouri H., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R.,
RA Fraser C.M.;
RT "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT environments.";
RL Science 302:1967-1969(2003).
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AE017180; AAR33677.1; -; Genomic_DNA.
DR RefSeq; NP_951404.1; NC_002939.5.
DR RefSeq; WP_010941012.1; NC_002939.5.
DR AlphaFoldDB; Q74GA2; -.
DR SMR; Q74GA2; -.
DR STRING; 243231.GSU0344; -.
DR EnsemblBacteria; AAR33677; AAR33677; GSU0344.
DR KEGG; gsu:GSU0344; -.
DR PATRIC; fig|243231.5.peg.341; -.
DR eggNOG; COG3383; Bacteria.
DR HOGENOM; CLU_000422_4_0_7; -.
DR InParanoid; Q74GA2; -.
DR OrthoDB; 9816402at2; -.
DR Proteomes; UP000000577; Chromosome.
DR GO; GO:0045272; C:plasma membrane respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0045333; P:cellular respiration; IBA:GO_Central.
DR CDD; cd00207; fer2; 1.
DR CDD; cd02771; MopB_NDH-1_NuoG2-N7; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.740; -; 2.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF12838; Fer4_7; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS51839; 4FE4S_HC3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
DR PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
PE 4: Predicted;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000577};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..79
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 79..118
FT /note="4Fe-4S His(Cys)3-ligated-type"
FT /evidence="ECO:0000259|PROSITE:PS51839"
FT DOMAIN 138..166
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 177..207
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 216..272
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 826 AA; 88098 MW; CCCDC5F37736AEB5 CRC64;
MVTLTIDDKQ VTVPKDATIF DAAKQAGIRI PILCHDKKLH PFGGCRMCLV EVEQMKGRQI
PACTTPVTEG MIVRTMTDEI VKARKMVLEL LLLKHPIDCP VCDAAGDCDL QNLTYEYGVD
TNRFTDEKFN WKIDYVNPLI ERDMNRCVHC GKCARICDEI VSFGAYSFIN RGIEAKIGTE
FDGPLNCEFC GSCVSVCPVG ALISRPFKFK ARWWALNKVK TVCSYCGTGC QLTLGVKDNK
VLTTIYDENQ GFHNGQLCTR GRWGYQFVNS SKRLTTPLIR KGDTLQPASW DEALGMVADR
LKTSKDAAAT LVTPRLTNEE LYLLKRVVKD AVGSDNLDHS GGYAHEALTA GARESLGFPG
SPSVIADIQK SELLLVIKTD AYETHPVIGF EVNLAVKRQG VALRILSDKK GKLSRLPGAQ
TYVHTPGAEL VLVNALAKTI VDEGLHDASS VGAIKGFDAW LKSIESCTPD QAAGQCGIAA
DTIKAVAREY AAAGKALIML PLGMGYPGHG KALAQALINL ALLTGRVGKE GCGVLIMGEK
NNSQGAADLG IHPTANGLNA QAILAGCSAG SIKTLYVVGE NPVVSYPNRK QVEAALDAVE
FLVVQDLFLT ETASKADVVL PACSFAEKDG TFTSLGGAVQ RVNRAITPLG DCRSDFDILN
MLHAKLTGQA AYTSQKEAFA DLAAATPGYA GLTLEGLGDA GAVRVNNCTA SFVPVATSTV
TTEAGKFALL TGSALNHSGT LSLYGEGPML VCPEGYLELN KDDAAKLSIT EGDAVTMKSA
TGELRLKAKV GTRLPQGVAF APYHFAEASI NSLTGATAIT WITISK
//
