ID LSRB_YERPE Reviewed; 339 AA.
AC Q74PW2; Q8CZM9;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=Autoinducer 2-binding protein LsrB;
DE Short=AI-2-binding protein LsrB;
DE Flags: Precursor;
GN Name=lsrB; OrderedLocusNames=YPO0409, y3772, YP_3772;
OS Yersinia pestis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Part of the ABC transporter complex LsrABCD involved in
CC autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and
CC LsrD permeases (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (LsrA),
CC two transmembrane proteins (LsrC and LsrD) and a solute-binding protein
CC (LsrB). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 2 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM87317.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL19090.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM87317.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS63920.1; -; Genomic_DNA.
DR PIR; AH0050; AH0050.
DR RefSeq; WP_002209189.1; NZ_WUCM01000002.1.
DR RefSeq; YP_002345486.1; NC_003143.1.
DR PDB; 3T95; X-ray; 1.75 A; A=26-339.
DR PDBsum; 3T95; -.
DR AlphaFoldDB; Q74PW2; -.
DR SMR; Q74PW2; -.
DR IntAct; Q74PW2; 1.
DR STRING; 214092.YPO0409; -.
DR PaxDb; 214092-YPO0409; -.
DR DNASU; 1148719; -.
DR EnsemblBacteria; AAS63920; AAS63920; YP_3772.
DR GeneID; 57974201; -.
DR KEGG; ype:YPO0409; -.
DR KEGG; ypk:y3772; -.
DR KEGG; ypm:YP_3772; -.
DR PATRIC; fig|214092.21.peg.649; -.
DR eggNOG; COG1879; Bacteria.
DR HOGENOM; CLU_037628_3_0_6; -.
DR OMA; KQVNNPY; -.
DR OrthoDB; 9781890at2; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR CDD; cd20003; PBP1_LsrB_Quorum_Sensing; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR030159; LsrB.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR025997; SBP_2_dom.
DR PANTHER; PTHR30036; D-XYLOSE-BINDING PERIPLASMIC PROTEIN; 1.
DR PANTHER; PTHR30036:SF1; D-XYLOSE-BINDING PERIPLASMIC PROTEIN; 1.
DR Pfam; PF13407; Peripla_BP_4; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..339
FT /note="Autoinducer 2-binding protein LsrB"
FT /id="PRO_0000351333"
FT STRAND 28..32
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 34..38
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 39..55
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 58..61
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 69..81
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 85..89
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 92..95
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 98..106
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 110..116
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 120..122
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 124..129
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 132..147
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 150..159
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 164..180
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 184..191
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 196..209
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 215..218
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 223..233
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 240..244
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 247..255
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 262..264
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 267..284
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 292..295
FT /evidence="ECO:0007829|PDB:3T95"
FT TURN 296..298
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 299..304
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 306..309
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 319..322
FT /evidence="ECO:0007829|PDB:3T95"
FT STRAND 327..329
FT /evidence="ECO:0007829|PDB:3T95"
FT TURN 331..333
FT /evidence="ECO:0007829|PDB:3T95"
FT HELIX 334..336
FT /evidence="ECO:0007829|PDB:3T95"
SQ SEQUENCE 339 AA; 36708 MW; 43DF0D22B6239FD3 CRC64;
MRTQRLKKLA LVCALGFACI TTAQAAERIA FIPKLVGVGF FTSGGKGAVD AGKALGVDVT
YDGPTEPSVS GQVQLINNFV NQGYNAIVVS AVSPDGLCPA LKRAMQRGVK ILTWDSDTKP
ECRSVYINQG TPNQLGSMLV DMAANQVKKE QAKVAFFYSS PTVTDQNQWV NEAKKKIQQE
HPGWEIVTTQ FGYNDATKSL QTAEGILKAY ADLDAIIAPD ANALPAAAQA AENLKRANVA
IVGFSTPNVM RPYVERGTVK EFGLWDVVNQ GKISVYVANE MLKKGDLNVG DKIDIPNIGV
VEVSPNRVQG YDYEAKGNGI VLLPQRVIFT KENISKYDF
//
