GenomeNet

Database: UniProt
Entry: Q755N4
LinkDB: Q755N4
Original site: Q755N4 
ID   DBP2_ASHGO              Reviewed;         557 AA.
AC   Q755N4;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   16-OCT-2019, entry version 103.
DE   RecName: Full=ATP-dependent RNA helicase DBP2;
DE            EC=3.6.4.13;
GN   Name=DBP2; OrderedLocusNames=AFL221C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL
OS   Y-1056) (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient
RT   Saccharomyces cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 337; 356; 367-368;
RP   394-407 AND 421.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved nonsense-mediated
CC       mRNA decay and ribosome biogenesis through rRNA processing.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with polysomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX5/DBP2
CC       subfamily. {ECO:0000305}.
DR   EMBL; AE016819; AAS53153.2; -; Genomic_DNA.
DR   RefSeq; NP_985329.2; NM_210683.2.
DR   SMR; Q755N4; -.
DR   STRING; 33169.AAS53153; -.
DR   PRIDE; Q755N4; -.
DR   EnsemblFungi; AAS53153; AAS53153; AGOS_AFL221C.
DR   GeneID; 4621553; -.
DR   KEGG; ago:AGOS_AFL221C; -.
DR   HOGENOM; HOG000268804; -.
DR   InParanoid; Q755N4; -.
DR   KO; K12823; -.
DR   OMA; DFKNLCM; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008186; F:RNA-dependent ATPase activity; IEA:EnsemblFungi.
DR   GO; GO:1990120; P:messenger ribonucleoprotein complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase;
KW   Nonsense-mediated mRNA decay; Nucleotide-binding; Nucleus;
KW   Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN         1    557       ATP-dependent RNA helicase DBP2.
FT                                /FTId=PRO_0000227944.
FT   DOMAIN      145    320       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      348    495       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     158    165       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   REGION      506    532       RNA-binding RGG-box. {ECO:0000250}.
FT   MOTIF       114    142       Q motif.
FT   MOTIF       268    271       DEAD box.
SQ   SEQUENCE   557 AA;  61728 MW;  F4B50BF264A09E1E CRC64;
     MSYAGNRDQQ FNRSNFGGRD GDHRGQRPSD RNSYGRDGFG RGGRGGFAGR GRGRSDDRLE
     LTKPDWDVES LPKFEKNFYV EHEDVQKMST DEVEQFRKEN EMKIVGHDVP KPIRTFDEAG
     FPEYVLKEVK EEGFEKPTAI QCQGWPMALS GRDMIGVAAT GSGKTLSYCL PGIVHINAQP
     LLSPGDGPVV LVLAPTRELA VQIQKECSKF GRSSRIRNTC VYGGVPKSQQ IRDLQRGVEI
     LIATPGRLID MLEIGKTNLK RVTYLVLDEA DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA
     TWPKEVQQLA RDYLHDPIQV NIGSLELAAS HTITQLVEVV SDFDKRDRLV KHLEIASKDK
     DSKIIIFAST KRTCDEITSY LRQDGWPALA IHGDKQQQER DWVLNEFRTG RSPIMVATDV
     AARGIDVKGI NFVINYDMPG NIEDYVHRIG RTGRAGATGT AISFFTEANK TLGAQLISIM
     REAKQEIPQD LLVYDRAPRG GFHPRYGGRG GRGGRGGRGG RGYGGYGGGY GGYGGGYGGG
     HGGYGGKPKD SGWGNRN
//
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