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Database: UniProt
Entry: Q756K8
LinkDB: Q756K8
Original site: Q756K8 
ID   CTM1_ASHGO              Reviewed;         478 AA.
AC   Q756K8;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   16-JAN-2019, entry version 73.
DE   RecName: Full=Cytochrome c lysine N-methyltransferase 1;
DE            EC=2.1.1.59;
GN   Name=CTM1; OrderedLocusNames=AER246W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL
OS   Y-1056) (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient
RT   Saccharomyces cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Methyltransferase which mediates trimethylation of
CC       cytochrome c (CYC1). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[cytochrome c]-L-lysine + S-adenosyl-L-methionine =
CC         [cytochrome c]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:24312, Rhea:RHEA-COMP:9754,
CC         Rhea:RHEA-COMP:9755, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929;
CC         EC=2.1.1.59; Evidence={ECO:0000255|PROSITE-ProRule:PRU00943};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- DOMAIN: The SET-like region, although related with the SET domain
CC       is not detected by any prediction method. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190, ECO:0000255|PROSITE-ProRule:PRU00943}.
DR   EMBL; AE016818; AAS52927.1; -; Genomic_DNA.
DR   RefSeq; NP_985103.1; NM_210457.1.
DR   ProteinModelPortal; Q756K8; -.
DR   STRING; 33169.AAS52927; -.
DR   EnsemblFungi; AAS52927; AAS52927; AGOS_AER246W.
DR   GeneID; 4621313; -.
DR   KEGG; ago:AGOS_AER246W; -.
DR   InParanoid; Q756K8; -.
DR   KO; K18804; -.
DR   OMA; IEVETAM; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000277; F:[cytochrome c]-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; IBA:GO_Central.
DR   GO; GO:0018023; P:peptidyl-lysine trimethylation; IBA:GO_Central.
DR   InterPro; IPR025815; Ctm1.
DR   InterPro; IPR001214; SET_dom.
DR   PROSITE; PS51611; SAM_MT59; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    478       Cytochrome c lysine N-methyltransferase
FT                                1.
FT                                /FTId=PRO_0000228981.
FT   DOMAIN       32    284       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   REGION      199    299       SET-like.
SQ   SEQUENCE   478 AA;  53392 MW;  7A392302D95972B5 CRC64;
     MRCGWMAGSS ETVGIMDTAD WYIGHGQVTV APCVSIERSQ IKSPDSGYGV FVDVDKLQEE
     ECEAVELLRV PYGNVISVRT LMDWLSGRGD GYDASKDLIK TYLALFLEDT SNHRFVTETN
     MLILYLALMA ILSERGYGFP DKFVIYLRDV LLQTRLLTPV LEVLTQEAGD AGAHYRNGPQ
     EIFLSTLLQF ISGAFMGCTR AVVLRVYAAV LSRCLEIPHE TSPGSEDYTV SSSLVPILDF
     TNHSCEHRNA YFDVDRESGD VLLMLDVAAC AGLGDRFEVF ISYCPVEELV HFKHTYGFFP
     RASCGTQFWH MFLSDTWLKE ERAPHGSGSL FQIYSELRVL PYIELALISG QVYVNDYCSS
     FPELLLPFVN IEALSDKESK LTALKGDQQL LAEAKTNFLS FLARYLDKLV ANGPIRHSGP
     VCASLRDILL RELELSKRLR NTLQHGSAFL SSHMADTSPP YCPSPAPSPP YAYMYTSS
//
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