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Database: UniProt
Entry: Q757Y8
LinkDB: Q757Y8
Original site: Q757Y8 
ID   SET2_ASHGO              Reviewed;         684 AA.
AC   Q757Y8;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   13-FEB-2019, entry version 106.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-36 specific;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain-containing protein 2;
GN   Name=SET2; OrderedLocusNames=AEL128C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL
OS   Y-1056) (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient
RT   Saccharomyces cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 531.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Histone methyltransferase that methylates histone H3 to
CC       form H3K36me. Involved in transcription elongation as well as in
CC       transcription repression (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00901};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- DOMAIN: The AWS and SET domains are necessary for transcription
CC       repression. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SET2 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00901}.
DR   EMBL; AE016818; AAS52557.2; -; Genomic_DNA.
DR   RefSeq; NP_984733.2; NM_210087.2.
DR   SMR; Q757Y8; -.
DR   STRING; 33169.AAS52557; -.
DR   EnsemblFungi; AAS52557; AAS52557; AGOS_AEL128C.
DR   GeneID; 4620920; -.
DR   KEGG; ago:AGOS_AEL128C; -.
DR   HOGENOM; HOG000248214; -.
DR   InParanoid; Q757Y8; -.
DR   KO; K11423; -.
DR   OMA; NHACGED; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IBA:GO_Central.
DR   GO; GO:0030437; P:ascospore formation; IEA:EnsemblFungi.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:EnsemblFungi.
DR   GO; GO:0016575; P:histone deacetylation; IEA:EnsemblFungi.
DR   GO; GO:0097676; P:histone H3-K36 dimethylation; IEA:EnsemblFungi.
DR   GO; GO:0097198; P:histone H3-K36 trimethylation; IEA:EnsemblFungi.
DR   GO; GO:0060195; P:negative regulation of antisense RNA transcription; IEA:EnsemblFungi.
DR   GO; GO:0071441; P:negative regulation of histone H3-K14 acetylation; IEA:EnsemblFungi.
DR   GO; GO:2000616; P:negative regulation of histone H3-K9 acetylation; IEA:EnsemblFungi.
DR   GO; GO:0045128; P:negative regulation of reciprocal meiotic recombination; IEA:EnsemblFungi.
DR   GO; GO:0035066; P:positive regulation of histone acetylation; IEA:EnsemblFungi.
DR   GO; GO:0030174; P:regulation of DNA-dependent DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:1900049; P:regulation of histone exchange; IEA:EnsemblFungi.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   Gene3D; 1.10.1740.100; -; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR025788; Hist-Lys_N-MeTrfase_SET2_fun.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR013257; SRI.
DR   InterPro; IPR038190; SRI_sf.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF08236; SRI; 1.
DR   Pfam; PF18507; WW_1; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS51568; SAM_MT43_SET2_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromosome; Coiled coil; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; Repressor; S-adenosyl-L-methionine;
KW   Transcription; Transcription regulation; Transferase.
FT   CHAIN         1    684       Histone-lysine N-methyltransferase, H3
FT                                lysine-36 specific.
FT                                /FTId=PRO_0000269779.
FT   DOMAIN       53    108       AWS. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00562}.
FT   DOMAIN      110    227       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   DOMAIN      234    250       Post-SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   DOMAIN      452    484       WW.
FT   COILED      518    594       {ECO:0000255}.
SQ   SEQUENCE   684 AA;  79779 MW;  78DDBE28F4078577 CRC64;
     MSRSSSPSVS LPLPSSATLF LDREDKTEEA LGTFIELEQC TYTHKRLGDS RSNEFMECDC
     FEDYKDEQNH ACDENSDCIN RLTLIECVND LCTSCGDDCQ NQRFQKKEYA DIAVFQTEKK
     GYGVRAERDI EANEFIYEYI GEVISEADFR DRMVDYDMRG FKHFYFMMLQ AGEFIDATER
     GCLARFCNHS CNPNAYVSKW DVAGKLKMGI FAHRKILKGE EITFDYNVDR YGATAQPCYC
     DEPNCIGFLG GKTQTDAASL LPQNYADALG VRPSVEKKWV KMRKALGEEI DKSGSSNINI
     EFVESLELEP CVQYSDVNKV MSVLLQIDDK FICSKLLERI LLTSDETMRY QIIKLHGYKC
     FSKLLGLFET DENTQHRILQ YLSDLPKTTK NGIVSSQIDK KVESLLQKEA LKEDASALLE
     RWNTYETYQR IAKKDFTKTS NGLNKVTDFR RVRLPLGWEI IHENGRPMYY NAQRQIKRVD
     PPSDTHLQRP ARTTPPQRYN GGFYDRTTKR PLDPESFEKR KRQRLEWEQQ ELAKKKQEEV
     RHLKEKLEVE KQKKSELEQI IEDANKQQEQ QRLERLQKEK ETAERRERRR QTHSASRIEH
     KWNKFFAQIV PNLIKSYATS MDRARIKECA RDIVKILSSK ELKKDATKVP PAEVTKEKRK
     KVNEFCKSYM DKLLAKMHEK AVSK
//
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